CAS: 1180-71-8; (4As,6Ar,8Ar,8Br,9As,12S,12As,14Ar,14Br)-12-(Furan-3-yl)-6,6,8A,12A-Tetramethyldecahydrooxireno[2,3-D]Pyrano[4',3':3,3A]Isobenzofuro[5,4-F]Isochromene-3,8,10(1H,6H,8Ah)-Trione

该化合物是自然产生的柑橘豪华轿车,以其强大的抗氧化特性和抑制脂过氧化的能力而闻名. 它的高度稳定性和功效使它在食品,化妆品和药品应用中成为有效的自然防腐剂,有可能提供更高的货架寿命和防范氧化性压力的保护.

结构式图片

欧盟法规

C&L通报

上下游产品

obacunone7α-limonol desoxylimonin S)-1α,4;6β,19;14,15β;21,23-tetraepoxy-17-hydroxy-4,4,8-trimethyl-7-oxo-3,4;16,17-diseco-24-nor-5α,13α,14β-chola-20,22-diene-3,16-dioic acid-16-lactone(17S)-1α,4;6β,19;14,15β;21,23-tetraepoxy-17-hydroxy-4,4,8-trimethyl-7-oxo-3,4;16,17-diseco-24-nor-5α,13α,14β-chola-20,22-diene-3,16-dioic acid-16-lactone shihulimonin A

合成工艺路线路线简述

    黄柏酮置于chromium(Vi) Oxide,乙酸酐,Sodium Tetrahydroborate体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应 4.0H,以76%的收率获得柠檬苦素
    参考文献:电热蚊香液及其制备方法
    标题:电热蚊香液及其制备方法
    摘要:本发明提供了一种新型的电热蚊香液,其包括药效成分,增效剂,抗氧化剂和溶剂,所述药效成分为柠檬苦素和富右旋烯丙菊酯.本发明提供的电热蚊香液,在传统的富右旋烯丙菊酯的基础上,搭配柠檬苦素,利用植物源驱蚊成分的添加,降低了富右旋烯丙菊酯的使用量,避免了富右旋烯丙菊酯的耐药性,进一步通过采用人工合成的方式制备驱蚊成分柠檬苦素,降低了生产成本,提高产品的批量化.

    专利信息


    专利号:EP-1239813-B1
    优先权日:1999-12-23
    标题:Extract of blue-green alga spirulina and the use thereof in cosmetic skin-care and body care agents
    发明人:SCHLOTMANN KORDULA; WALDMANN-LAUE MARIANNE; JASSOY CLAUDIA; KAETEN MELANIE; KOEHLER EVA-MARIA; PULZ OTTO; KURTH ELKE
    权利人:HENKEL KGAA
    摘要:The invention relates to an aqueous or aqueous-alcoholic extract of the blue-green algal taxon Spirulina, characterized in that it contains at least 10 wt. % magnesium in relation to the dry weight of said extract. The inventive blue-green alga extract is an efficacious component for stimulating intracellular synthesis of ATP and matrix proteins and differentiation of keratinozytes. The blue-green alga extract is used in topical preparations for cleaning and cosmetic care of the skin and hair, in addition to the production of agents for dermatological treatment of the skin.

    专利号:US-2022127649-A1
    优先权日:2019-01-30
    标题:Engineered cells for improved production of cannabinoids
    发明人:NOBLE MICHAEL A; MOORE JONATHAN; LI JINGYI; LECHNER ANNA
    权利人:GENOMATICA INC
    摘要:The invention provides non-natural microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing synthesis of olivetolic acid, olivetolic acid derivatives and/or cannabinoids.

    专利号:US-11773128-B2
    优先权日:2019-03-28
    标题 :Electrocatalytic synthesis of dihydrochalcones
    发明人:REDKO MIKHAIL; SAFFRON CHRISTOPHER M; JACKSON JAMES E
    权利人:UNIV MICHIGAN STATE
    摘要:The disclosure relates to methods of forming a dihydrochalcone using electrocatalytic dehydrogenation. In particular, the disclosure relates to methods of forming a dihydrochalcone electrocatalytically hydrogenating (ECH) a reactant compound over a catalytic cathode in a reaction medium having a non-alkaline pH value, thereby forming a dihydrochalcone product; wherein the reactant compound has a structure according to Formula (I). The method can be used to prepare dihydrochalcone sweeteners, such as, for example, naringin dihydrochalcone and neohesperidin dihydrochalcone.

    专利号:US-2014357576-A1
    优先权日:2013-05-31
    标题:Methods for enhancement of muscle protein synthesis
    发明人:BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN
    权利人:NESTEC SA
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.

    专利号:WO-2015040533-A1
    优先权日:2013-09-19
    标题:Methods for enhancing muscle protein synthesis during energy deficit
    发明人:BAILEY DAVID MARK; ZALTAS ERIC SCOTT; STELLINGWERFF TRENT; MOORE DANIEL RYAN; HAWLEY JOHN ALAN; BURKE LOUISE MARY
    权利人:PREMIER NUTRITION CORP
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis during periods of negative energy balance, or energy deficit. The methods include administering to an individual suffering from energy deficit a composition comprising protein in an amount from about 15 g to about 30 g during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof. The methods also include administering to an individual suffering from energy deficit a composition comprising protein during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof, wherein the protein is administered in a dose that is higher than doses typically recommended for individuals experiencing energy balance.

    专利号:US-2014294788-A1
    优先权日:2013-03-26
    标 题 :Methods for enhancing muscle protein synthesis following concurrent training
    发明人:BAILEY DAVID MARK; ZALTAS ERIC SCOTT; MOORE DANIEL RYAN; STELLINGWERFF TRENT
    权利人:NESTEC SA
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis following physical exertion. In a general embodiment, a method for enhancing muscle protein synthesis following physical exertion is provided and includes administering to an individual a composition comprising from about 15 to about 35 g protein immediately following concurrent training. Programs for enhancing muscle adaptation resulting from concurrent training are also provided. The programs include providing a composition comprising from about 15 to about 35 g protein; and providing guidelines for consumption including a recommendation of the amount of the composition to consume immediately following concurrent training.
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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Eraky MA, El-Kholy AA, Rashed GA, Hammam OA, Moharam AF, Abou-Ouf EA, Aly NS, Kishik SM, Abdallah KF, Hamdan DI. Dose-response relationship in Schistosoma mansoni juvenile and adult stages following limonin treatment in experimentally infected mice. Parasitol Res. 2016 Jun 20. [Epub ahead of print] doi: 10.1016/j.plaphy.2016.04.039. [Epub ahead of print] doi: 10.1016/j.nutres.2015.10.011. Epub 2015 Oct 31. doi: 10.3390/molecules201219840. doi: 10.1039/c5fo00489f. Epub 2015 Aug 24. doi: 10.3164/jcbn.15-28. Epub 2015 Jun 17.
    7: Yamashita S, Naruko A, Nakazawa Y, Zhao L, Hayashi Y, Hirama M. Total Synthesis of Limonin. Angew Chem Int Ed Engl. 2015 Jul 13;54(29):8538-41. doi: 10.1002/anie.201503794. Epub 2015 Jun 3. doi: 10.1002/rcm.7026. doi: 10.1111/1750-3841.12581. Epub 2014 Sep 11. doi: 10.4103/0973-1296.137381.
    12: Yang N, Wang J, Liu C, Song Y, Zhang S, Zi J, Zhan J, Masilamani M, Cox A, Nowak-Wegrzyn A, Sampson H, Li XM. Berberine and limonin suppress IgE production by human B cells and peripheral blood mononuclear cells from food-allergic patients. Ann Allergy Asthma Immunol. 2014 Nov;113(5):556-564.e4. doi: 10.1016/j.anai.2014.07.021. Epub 2014 Aug 22. doi: 10.1016/j.ejphar.2014.06.010. Epub 2014 Jun 23. doi: 10.1016/j.bmcl.2014.02.003. Epub 2014 Feb 10. doi: 10.1007/s00210-013-0937-1. Epub 2013 Nov 21. doi: 10.1155/2013/827361. Epub 2013 May 8.

    合成参考文献


    参考文献:10.1021/np060217s
    摘要:Nakagawa H, Takaishi Y, Tanaka N, Tsuchiya K, Shibata H, Higuti T. Chemical Constituents from the Peels of Citrus sudachi. J. Nat. Prod. 2006 Aug 01;69(8):1177–9. doi: 10.1021/np060217s.
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