CAS: 116539-57-2; (R)-3-(Methylamino)-1-(Thiophen-2-yl)Propan-1-Ol

上下游产品

CAS号597581-30-1 (R)-(3-hydroxy-... | CAS号88-15-3 2-乙酰基噻吩 | CAS号116539-56-1 3-甲氨基-1-(2-噻吩基)-1-丙醇 | CAS号663603-70-1 (2Z)-3-(METHYLA... | CAS号98-03-3 2-噻吩甲醛

📜2-乙酰基噻吩置于[rh{(Rc,Sp)-Duanphos}(Norbornadiene)]Sbf6 盐酸,氢气,Potassium Carbonate体系中,用 甲醇,乙醇 用作溶剂,20.0~110.0 °C,1000.0 Kpa 条件下,反应 12.0H,反应生成(R)-3-甲基氨基-1-(2-噻吩基)-1-丙醇
参考文献:铑催化β-仲氨基酮的不对称加氢,实际合成对映体纯的γ-氨基醇.
标题:铑催化β-仲氨基酮的不对称加氢,实际合成对映体纯的γ-氨基醇.
摘要:
Doi:10.1002/anie.200462178

专利信息

专利号:US-2004249170-A1
优先权日:2002-01-24
标 题 :Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine
发明人：BORGHESE ALFIO
摘要:This invention provides a process for the synthesis of(S)-3-Methylamino-1-2-thienyl)-1-propanol, a key intermediate in the synthesis of duloxetine.

专利号:US-2005171360-A1
优先权日:2002-02-22
标题:Preparation of n-methyl-3-hydroxy- 3-(2-thienyl)propylamine via novel thiophene derivatives containing carbamate groups as intermediates
发明人：REICHERT DIETMAR; ALMENA PEREA JUAN J; SCHWARM MICHAEL; DRAUZ KARLHEINZ; KRIMMER HANS-PETER
摘要:A novel route is described for the synthesis of N-methyl-3-hydroxy-3-(2-thienyl)propylamine IV, which can be used as a starting compound for the preparation of duloxetine. N-methyl-3-hydroxy-3-(2-thienyl)propylamine is synthesized via novel thiophene derivatives containing carbamate groups, I and IIa, as intermediates.

专利号:WO-03062219-A1
优先权日:2002-01-24
标题:Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine

专利号:EP-1478641-A1
优先权日:2002-01-24
标 题 :Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine