专利号:US-6835841-B2 优先权日:2002-09-13 标 题:Asymmetric catalytic hydrogenation process for preparation of chiral cyclic β-aminoesters 发明人:DEERBERG JOERG; MCLEOD DOUGLAS D; YUE TAI-YUEN 权利人:BRISTOL MYERS SQUIBB CO 摘要:A novel process for the asymmetric synthesis of substituted cyclic beta-amino-carboxylates of the type shown in the specification from appropriate beta-enamino-ester starting materials is described. These compounds are useful as intermediates for MMP and TACE inhibitors.
专利号:US-7309799-B2 优先权日:2004-06-01 标 题:Methods for the synthesis of milnacipran and congeners thereof 发明人:BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V 权利人:COLLEGIUM PHARMACEUTICAL INC 摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.
专利号:US-2003072716-A1 优先权日:2001-06-22 标 题:Renewable, carbohydrate based CO2-philes 发明人:POOVATHINTHODIYIL RAVEENDRAN; WALLEN SCOTT L 摘要:A composition is disclosed comprising a carbohydrate-based material a dispersed in carbon dioxide. A general method for synthesizing inexpensive, renewable, non-toxic, non-fluorous, carbohydrate based CO 2 -philes is disclosed. These CO 2 -philes are soluble in carbon dioxide. Methods of making the composition are also disclosed. The methods and composition are useful in a variety of applications and can utilize gaseous, liquid and supercritical carbon dioxide. The methods and compositions are useful in the synthesis of surfactants and metal chelates for CO 2 , as a sizing substrate, in CO 2 -based coating processes, for impregnation and plasticizing cellulosic and non-cellulosic materials, in pharmaceutical applications, such as crystallization, dispersion and encapsulation of bioactive molecules in solid systems, in the densification of CO 2 , in the synthesis of biodegradable polymers in CO 2 , and for carbon dioxide removal, to name just a few.
专利号:US-2005282898-A1 优先权日:2004-06-01 标 题 :Methods for the synthesis of milnacipran and congeners thereof
专利号:WO-2023239529-A2 优先权日:2022-06-09 标题 :On-slide synthesis of a schiff reagent
专利号:WO-2005118564-A2 优先权日:2004-06-01 标 题:Methods for the synthesis of milnacipran and congeners thereof
摘要:Mourad, A. K.; Czekelius, C., Science of Synthesis Knowledge Updates, (2011) 3, 86. 摘要:Adriaensen, K.; De Vos, D., Science of Synthesis, (2022) , 163. 摘要:Industrial Medicine and Surgery., 41(31), 1972