CAS: 97-59-6; 1-(2,5-Dioxoimidazolidin-4-yl)Urea

• 英文名称1-(2,5-Dioxoimidazolidin-4-yl)Urea
• 中文名称尿囊素
• IUPAC名称1-(2,5-dioxoimidazolidin-4-yl)urea
• 其它别名尿囊素; 1脲基间二氮杂茂烷24二酮; 5-Ureidohydantoin
• CAS编号97-59-6
• MFCD编号:MFCD00005260
• EINECS号:202-592-8
• FDA UNII编号:344S277G0Z
• 分子式:C4H6N4O3
• 分子量:158.12
• 产品CID: 2022194
• 同类组份化合物CAS97-59-6 (racemic)3844-67-5 (S-isomer)7303-80-2 (R-isomer)565227-55-6 (panthenol)1317-25-5 (Alcloxa)
• 产品分类有机原料→生命科学→生化试剂→天然产物

• 相似结构搜索
• 产品信息参考;;;
• InChIKey: POJWUDADGALRAB-UHFFFAOYNA-N
• InChI=1/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11)…
• 计算化学: 氢键受体数3.0氢键供体数4.0可旋转键数1.0

相似化合物

物理性质

• 熔点230°C
• 沸点283.17 °C at 760 mmHg
• 闪点230-234 °C
• 密度1.7±0.1 g/cm3
• pKa:8.96(at 25°C)
• PSA:113.32
• LogP:-2.1798
• 折射率1.616
• 蒸汽压4.32X10-9 mm Hg at 25 °C (est)
• 溶解性水: Soluble0.1G/10 Ml, Clear, Colorless
• 敏感性无臭无味。在干燥空气中稳定，在水中长时间煮沸或在强碱中则被破坏。
• 外观形态白色粉末
• 储存条件2-8°C
• 产品应用尿囊素具有促进皮细胞生长,使伤口迅速愈合的作用.用作抗溃疡药,与干燥氢氧化铝凝胶混和,用于消化道溃疡及炎症.该品又能软化角质素,使皮肤保持水分,滋润和柔软,是化妆品的特效添加剂.尿囊互及其衍生物还是许多日用化工产品的品质改良剂,添加剂.尿囊素蛋白质可配制抗刺激,抗头皮屑,清洁及使伤口愈合的头皮制剂,能使头发柔软,有光泽和弹性.该品是一种两性化合物,能结合多种物质形式复盐,具有避光,杀菌防腐,止痛,除臭,抗氧化作用,因此是日用化工产品,美容化妆品如雀斑霜,粉刺液,香波,肥皂,牙膏,刮脸洗剂,收敛液,抗汗除
• 性质描述无色结晶性粉末.熔点238-240°C(分解).能溶于热水,热醇和稀氢氧化钠溶液,微溶于水和醇,几乎不溶于醚和氯仿.无臭,无味.在干燥空气中稳定,在水中长时间煮沸或强碱中则被破坏.饱和水溶液的pH为5.5.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2A
  急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
  严重眼刺激 类别2
• 警示词Warning(警告)
• 危险描述H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H332 |吸入有害.
  H312 |皮肤接触有害.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• UN编号NONH for all modes of transport
• 危险品标志Xn,Xi
• 安全声明22-24/25-36-26
• 危险类别码22-36/37/38
• WGK Germany1

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 Allantoin 主要起始原料 Urea And Glyoxylic Acid
• 24764-63-4 + 590-28-3 = 97-59-6
  反应条件:1.1 Solvents: Acetic Acid,Water; 10 Min,Rt; 2 - 3 H,Rt
  标题:Synthesis Of Sulofenur Analogs As Antitumour Agents: Part Ii
  作者:Youssef,Khairia M.; Al-Abdullah,Ebtihal; El-Khamees,Hamad
  参考文献:Medicinal Chemistry Research 日期:2003 卷标:11(9) 页码:481-503]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: Tin Tetrachloride,Hydrochloric Acid,Starch,Dodecanoic Acid,Bismuth(3+) Salt (3:1) Solvents: Water; 30 Min,Ph 5,25 °C1.2 Reagents: Potassium Hydroxide; 6 H,20 °C1.3 25 °C -> 230 °C; 35 Min,230 °C; 230 °C -> 390 °C; 3 H,390 °C1.4 Catalysts: Sulfuric Acid; 10 H,Ph 31.5 4 H,75 °C
  标题:Preparation Method Of Allantoin Catalyzed By Tin Dioxide-Based Complex/sulfuric Acid Composition
  参考文献:China]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Reagents: Hydrochloric Acid,Nitric Acid Catalysts: Zinc Oxide (Zno) (Titanium Dioxide-Based Composite Solid),Copper Oxide (Cuo) (Titanium Dioxide-Based Composite Solid),Zinc Chloride,Niobium Pentachloride,Titania (Titanium Dioxide-Based Composite Solid),Silver Oxide (Ag2O) (Titanium Dioxide-Based Composite Solid); 4 H,75 °C
  标题:Preparation Method Of Allantoin Catalyzed By Titanium Dioxide-Based Composite Solid Catalyst
  参考文献:China]
  
  57-13-6 + 107-22-2 = 97-59-6
  反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Tungsten Hydroxide Oxide Phosphate Solvents: Water; 60 - 90 Min,40 °C; 90 Min,60 °C
  标题:Synthesis Method Of Allantoin
  参考文献:China]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: Phosphoric Acid,Sulfuric Acid Solvents: Ethanol,Tetrahydrofuran; 4 H,Rt -> 75 °C
  标题:Study On Synthesis Technology Of Glyoxylic Acid Fine Chemicals
  作者:Zhang,Shuxin
  参考文献:Advanced Materials Research (Durnten-Zurich 日期:2012 卷标:(2012) 页码:573-574]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: Sulfamic Acid Solvents: Water; 7 H,60 °C
  标题:Process For Preparation Of Allantoin
  参考文献:China]
  
  57-13-6 + 107-22-2 = 97-59-6
  反应条件:1.1 Reagents: Nitric Acid; 5 H,41 °C1.2 4 H,75 °C
  标题:Hydrothermal Synthesis Of Large-Size Allantoin Crystals
  参考文献:China]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: Dowex 50W-X8 Solvents: Water; 17 H,343 K
  标题:Heterogeneous Catalysis In The Synthesis And Reactivity Of Allantoin
  作者:Cativiela,Carlos; Fraile,Jose M.; Garcia,Jose I.; Lazaro,Beatriz; Mayoral,Jose A.; Et Al
  参考文献:Green Chemistry 日期:2003 卷标:5(2) 页码:275-277]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Solvents: Water; 12 H,90 °C
  标题:Preparation Method Of Allantoin For Cosmetic With Catalyst Of Solid Superacid Wo3/al2O3-Zro2 And Fe-Based Solid Ionic Liquid Composite
  参考文献:China]
  
  57-13-6 + 107-22-2 = 97-59-6
  反应条件:1.1 Reagents: Nitric Acid; 5 H,41 °C1.2 Catalysts: Tin,Cobalt,Bismuth,Sulfuric Acid; 4 H,75 °C
  标题:Catalytic Preparation Method Of Allantoin Bases On Tin Dioxide-Based Composite/sulfuric Acid Composition
  参考文献:China]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: Phosphoric Acid,Sulfuric Acid Solvents: Ethanol,Tetrahydrofuran,Water; Rt -> 75 °C; 4 H,75 °C
  标题:Study On Synthesis Of N-(2,5-Dioxo-4-Imidazolidinyl)Urea (Allantoin)
  作者:Pei,Lei; Liu,Fusheng; Yu,Shitao
  参考文献:Qingdao Keji Daxue Xuebao 日期:2008 卷标:29(2) 页码:106-109]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: Sulfamic Acid,Sulfuric Acid Solvents: Water; 6 - 8 H,65 °C; 6 - 8 H,0.06 Mpa,65 °C
  标题:Preparation Method Of Environmentally-Friendly High-Yield Allantoin
  参考文献:China]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: Molybdenum Oxide (Moo3),Zirconium Dioxide,Cerium Oxide (Ce2O3) Solvents: Water; 8 H,90 °C
  标题:Preparation Method Of Allantoin For Cosmetics
  参考文献:China]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: Sulfuric Acid,Boric Acid (H3Bo3); 4 H,75 °C
  标题:Ferric Oxide Based Composite/sulfuric Acid/boric Acid Composition For Catalytic Preparation Of Allantoin And Its Preparation Method
  参考文献:China]
  
  496-46-8 = 97-59-6
  反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Cupric Chloride Solvents: Water; 4.5 H,65 - 75 °C
  标题:Study On Synthesis Of Allantoin
  作者:Truong,Phuong; Le Thi,Ngoc Trang; Dang,Thi Kieu Nga
  参考文献:Tap Chi Duoc Hoc 日期:2010 卷标:50(12) 页码:38-43]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: Molybdenum Oxide (Moo3),Niobium Pentoxide,Zirconium Dioxide; 14 H,80 °C
  标题:Method For Preparing Allantoin By Using Solid Super Acid/cobalt-Based Ionic Liquid Composite Catalyst And Its Application In Cosmetic
  参考文献:China]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: Sulfuric Acid,Ammonium Bisulfate Solvents: Water; Rt -> 68 °C; 12 H,68 °C
  标题:Method For Synthesis Of Allantoin
  参考文献:China]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: 1-Methyl-3-(4-Sulfobutyl)Imidazolium Hydrogen Sulfate Solvents: Water; Rt -> 50 °C; 6.5 H,50 °C -> 68 °C
  标题:Process For Synthesis Of Allantoin
  参考文献:China]
  
  57-13-6 + 298-12-4 = 97-59-6
  反应条件:1.1 Catalysts: Lanthanum Sesquioxide,Titanium Tetrachloride; 3 H,73 - 75 °C
  标题:Synthesis Of Allantoin By So4+2%∓/tio2-La+3++ Rare-Earth Solid Superacid
  作者:Jin,Huafeng; Xiang,Jiming; Li,Baozhang
  参考文献:Huaxue Yanjiu Yu Yingyong 日期:2003 卷标:15(3) 页码:381-382]
  
  = 97-59-6
  反应条件:1.1 Reagents: Acetic Acid
  标题:2-Amino-4-Nitrophenol
  作者:Hartman,W. W.; Silloway,H. L.
  参考文献:Organic Syntheses 日期:1945 卷标:25 页码:5-7

海关参考信息

• 2912110000-甲醛
  2912120000-乙醛
  2921211000-乙二胺
  2924199090-其他无环酰胺
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管