CAS: 876-93-7; 1-Phenyl-1H-Pyrazol-5-Ol

该化合物是一种环环生物化合物,其1位置为1位置的苯基核心,在5位置为1位置的苯基组和氢氧基组,该结构具有独特的反应性,使其成为制药和农用化学合成中有价值的中间体.其芳香和热循环特性使得人们能够参与各种化学变异,包括电益替代和金属催化联动反应.氢氧基组提高了溶解性,并为进一步功能化提供了一个场所,促进了生物活性衍生物的发展.该化合物的稳定性和定义明确的合成路径确保了研究和工业应用的一贯性,特别是在药剂和特殊化学品的设计方面.

结构式图片

相似化合物

942-32-5 2396658-67-4 90564-80-0

欧盟法规

C&L通报

上下游产品

methyl 3-methoxyprop-2-enoate phenylhydrazine 1-(5-hydroxy-1-phenyl-1H-pyrazol-4-yl)ethan-1-one (E)-1-(5-hydroxy-1-phenyl-(1H)-pyrazole-4-yl)-3-phenylprop-2-ene-1-one (5-hydroxy-1-phenyl-1H-pyrazol-4-yl)(2-thienyl)methanone (5-hydroxy-1-phenyl-1H-pyrazol-4-yl)(phenyl)methanone

合成工艺路线路线简述

  • 合成目标产物 1-Phenyl-1H-Pyrazol-5-Ol 主要起始原料 Methyl 3-Methoxyacrylate And Phenylhydrazine
  • (文献来源)合成步骤主要原料 Methyl 3-Methoxyacrylate 和 Phenylhydrazine

海关参考信息

专利信息


专利号:US-6362009-B1
优先权日:1997-11-21
标 题 :Solid phase synthesis of heterocycles
发明人:MUNOZ BENITO; CHEN CHIXU
权利人:MERCK & CO INC
摘要:Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrahydropyridines and tetrahydropyridines compounds and libraries containing such compounds are provided. Methods for screening the libraries and compounds and pharmaceutical compositions containing compounds prepared by the methods are provided.

专利号:US-5233044-A
优先权日:1989-06-08
标题:Active esters for solid phase peptide synthesis
发明人:HUDSON DEREK
权利人:MILLIPORE CORP
摘要:Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystalline, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectrophotometric monitoring and automation of peptide synthesis.

专利号:EP-0401797-A1
优先权日:1989-06-08
标 题:Active esters for solid phase peptide synthesis
发明人:HUDSON DEREK
权利人:MILLIPORE CORP
摘要:Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystal­line, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectro­photometric monitoring and automation of peptide synthesis.

专利号:WO-2013171755-A2
优先权日:2012-03-09
标题:'combustion synthesis of nanocrystalline alkali and alkaline earth metal oxides or mixture thereof and its applications in synthesis of [4- (alkyl/aryl)-oxy- 1,3 -dioxolane-2- one] and 2-oxazolidinones'

专利号:US-5866723-A
优先权日:1991-09-25
标 题 :Benzoyl derivatives and synthesis thereof
发明人:HAMPER BRUCE C; LESCHINSKY KINDRICK L
权利人:MONSANTO CO
摘要:The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of aryl-haloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.

专利号:US-6264891-B1
优先权日:1998-12-22
标题 :Apparatus and method for concurrent chemical synthesis
发明人:HEYNEKER HERBERT L; HA KIM D; STEINMILLER DAVID K; SIMONYI VICTOR
权利人:EOS BIOTECHNOLOGY INC
摘要:This invention provides an apparatus for preparing chemical libraries. The apparatus includes (1) a carousel comprising a plurality of reaction mounts having at least one reaction well; (2) a rotator that rotates the carousel step-wise; (3) a fluid delivery system; (4) a drain system; and (5) a programmable computer that controls the operation of the apparatus, including the rotator, the fluid delivery system, the drain system and other systems in the apparatus. The preparation of chemical libraries involves rotating the carousel through a plurality of stations. At each station, a physical step in a reaction protocol is carried out on the reaction wells of the mount docked at the station.

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合成参考文献


参考文献:10.1007/978-94-010-9060-5_305
摘要:Stanovnik, B.; Svete, J., Science of Synthesis, (2002) 12, 185.
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