专利号:US-6362009-B1 优先权日:1997-11-21 标 题 :Solid phase synthesis of heterocycles 发明人:MUNOZ BENITO; CHEN CHIXU 权利人:MERCK & CO INC 摘要:Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrahydropyridines and tetrahydropyridines compounds and libraries containing such compounds are provided. Methods for screening the libraries and compounds and pharmaceutical compositions containing compounds prepared by the methods are provided.
专利号:US-5233044-A 优先权日:1989-06-08 标题:Active esters for solid phase peptide synthesis 发明人:HUDSON DEREK 权利人:MILLIPORE CORP 摘要:Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystalline, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectrophotometric monitoring and automation of peptide synthesis.
专利号:EP-0401797-A1 优先权日:1989-06-08 标 题:Active esters for solid phase peptide synthesis 发明人:HUDSON DEREK 权利人:MILLIPORE CORP 摘要:Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystalÂline, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectroÂphotometric monitoring and automation of peptide synthesis.
专利号:WO-2013171755-A2 优先权日:2012-03-09 标题:'combustion synthesis of nanocrystalline alkali and alkaline earth metal oxides or mixture thereof and its applications in synthesis of [4- (alkyl/aryl)-oxy- 1,3 -dioxolane-2- one] and 2-oxazolidinones'
专利号:US-5866723-A 优先权日:1991-09-25 标 题 :Benzoyl derivatives and synthesis thereof 发明人:HAMPER BRUCE C; LESCHINSKY KINDRICK L 权利人:MONSANTO CO 摘要:The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of aryl-haloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.
专利号:US-6264891-B1 优先权日:1998-12-22 标题 :Apparatus and method for concurrent chemical synthesis 发明人:HEYNEKER HERBERT L; HA KIM D; STEINMILLER DAVID K; SIMONYI VICTOR 权利人:EOS BIOTECHNOLOGY INC 摘要:This invention provides an apparatus for preparing chemical libraries. The apparatus includes (1) a carousel comprising a plurality of reaction mounts having at least one reaction well; (2) a rotator that rotates the carousel step-wise; (3) a fluid delivery system; (4) a drain system; and (5) a programmable computer that controls the operation of the apparatus, including the rotator, the fluid delivery system, the drain system and other systems in the apparatus. The preparation of chemical libraries involves rotating the carousel through a plurality of stations. At each station, a physical step in a reaction protocol is carried out on the reaction wells of the mount docked at the station.