CAS: 84538-40-9; 2,4-Dimethoxy-5H-Pyrrolo[3,2-D]Pyrimidine

该化合物是三相循环化合物,其内含二和四位的苯丙胺核心与甲氧基替代成分.这一结构具有独特的电子和消毒特性,使其成为制药和农用化学研究的宝贵中间体.它的硬骨架对于设计动脉酶抑制剂和核核素类比特别有用,而精确的分子识别至关重要.甲氧基组增强了溶性和稳定性,有利于进一步的功能化.该组的高度纯度和定义明确的再活动特征使其适合探索性合成和结构活性关系研究.它通常用于药用化学开发有针对性的治疗方法.

结构式图片

相似化合物

144216-57-9 1375301-68-0 5655-01-6

物理性质

MSDS等安全信息

上下游产品

CAS号84538-44-3 4-cyanomethyl-2... | CAS号83256-18-2 2,4-dimethoxy-6... | CAS号30561-09-2 5-nitro-2,4-dim... | CAS号84538-41-0 6-(bromomethyl)... | CAS号13162-26-0 2,4-二氯-5-硝基-6-甲基嘧啶 | CAS号60331-03-5 4-chloro-2,6-di...

合成工艺路线路线简述

  • 合成目标产物 2,4-Dimethoxy-5H-Pyrrolo[3,2-D]Pyrimidine 主要起始原料 5-Nitro-2,4-Dimethoxy-6-Methylpyrimidine
  • 154781-75-6 + 84538-41-0 = 84538-40-9
    反应条件:1.1 Catalysts: Potassium Cyanide Solvents: Methanol2.1 -
    标题:Synthetic Strategies For 2,4-Dimethoxypyrrolo[3,2-D]Pyrimidine
    作者:Cupps,Thomas L.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1983 卷标:48(7) 页码:1060-4]

    84538-44-3 = 84538-40-9 [标题:Reaction Conditions
    标题:Synthetic Strategies For 2,4-Dimethoxypyrrolo[3,2-D]Pyrimidine
    作者:Cupps,Thomas L.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1983 卷标:48(7) 页码:1060-4]

    84538-44-3 = 84538-40-9 [标题:Reaction Conditions
    标题:A Novel Method For The Synthesis Of 6,7-Unsubstituted Pyrrolo[3,2-D]Pyrimidines
    作者:Cupps,Thomas L.; Et Al
    参考文献:Tetrahedron Letters 日期:1982 卷标:23(46) 页码:4759-62]

    83256-18-2 = 84538-40-9 [标题:Reaction Conditions
    标题:Synthetic Strategies For 2,4-Dimethoxypyrrolo[3,2-D]Pyrimidine
    作者:Cupps,Thomas L.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1983 卷标:48(7) 页码:1060-4]

    5815-08-7 + 30561-09-2 = 84538-40-9 [标题:Reaction Conditions
    标题:Synthetic Strategies For 2,4-Dimethoxypyrrolo[3,2-D]Pyrimidine
    作者:Cupps,Thomas L.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1983 卷标:48(7) 页码:1060-4]

    773837-37-9 + 84538-41-0 = 84538-40-9
    反应条件:1.1 Catalysts: Sodium Cyanide Solvents: Ethanol2.1 -
    标题:A Novel Method For The Synthesis Of 6,7-Unsubstituted Pyrrolo[3,2-D]Pyrimidines
    作者:Cupps,Thomas L.; Et Al
    参考文献:Tetrahedron Letters 日期:1982 卷标:23(46) 页码:4759-62]

    13162-26-0 = 84538-40-9 [标题:Reaction Conditions
    标题:Synthetic Strategies For 2,4-Dimethoxypyrrolo[3,2-D]Pyrimidine
    作者:Cupps,Thomas L.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1983 卷标:48(7) 页码:1060-4]

    30561-09-2 = 84538-40-9
    反应条件:1.1 Reagents: Bromine2.1 Catalysts: Potassium Cyanide Solvents: Methanol3.1 -
    标题:Synthetic Strategies For 2,4-Dimethoxypyrrolo[3,2-D]Pyrimidine
    作者:Cupps,Thomas L.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1983 卷标:48(7) 页码:1060-4]

    30561-09-2 = 84538-40-9
    反应条件:1.1 Reagents: Bromine Catalysts: Acetic Acid2.1 Catalysts: Sodium Cyanide Solvents: Ethanol3.1 -
    标题:A Novel Method For The Synthesis Of 6,7-Unsubstituted Pyrrolo[3,2-D]Pyrimidines
    作者:Cupps,Thomas L.; Et Al
    参考文献:Tetrahedron Letters 日期:1982 卷标:23(46) 页码:4759-62
📜2,4-二氯-5-硝基-6-甲基嘧啶置于t1-Raney Nickel 氢气体系中,用 甲醇,乙醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 19.17H,反应生成 2,4-二甲氧基-5H-吡咯并[3,2-D]嘧啶
参考文献:Synthetic Strategies For 2,4-Dimethoxypyrrolo[3,2-D]Pyrimidine
标题:Synthetic Strategies For 2,4-Dimethoxypyrrolo[3,2-D]Pyrimidine
摘要:
DOI:10.1021/jo00155A026

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主要参考文献

参考标题:Condensed Heteroaromatic Ring Systems. Xxi. Synthesis Of Pyrrolo(2,3-D)Pyrimidines And Pyrrolo(3,2-D)Pyrimidines.
作者:Takao Sakamoto,Chisato Satoh,Yoshinori Kondo,Hiroshi Yamanaka
摘要:Pyrrolo[2, 3-D]Pyrimidines And Pyrrolo[3, 2-D]Pyrimidines Were Synthesized In High Yields By The Palladiumcatalyzed Reaction Of 4-Acetylamino-5-Bromopyrimidines And 5-Acetylamino-4-Iodopyrimidines With (Z)-1-Ethoxy-2-(Tributylstannyl)Ethene Followed By Cyclization Under Acidic Conditions.

合成参考文献

参考DOI号:10.1016/S0040-4039(00)85706-8
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