CAS: 84225-95-6; (S)-3,5-Dichloro-N-((1-Ethylpyrrolidin-2-yl)Methyl)-2-Hydroxy-6-Methoxybenzamide

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CAS号22795-99-9 (S)-2-(氨甲基)-1-乙基吡咯烷 | CAS号13939-06-5 六羰基钼 | CAS号84225-94-5 (S)-(-)-3,5-dic... | CAS号119670-11-0 (S)-O-去甲基雷氯必利 | CAS号74-88-4 碘甲烷 | CAS号73219-91-7 3,5-二氯-2,6-二甲氧基苯甲酸 | CAS号32541-62-1 3,5-dichloro-2,... | CAS号119670-11-0 (S)-O-去甲基雷氯必利

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  • 84225-94-5 = 84225-95-6
    反应条件:1.1 Reagents: Hydrochloric Acid,Boron Tribromide Solvents: Diethyl Ether
    标题:Potential Neuroleptic Agents. 4. Chemistry,Behavioral Pharmacology,And Inhibition Of [3H]Spiperone Binding Of 3,5-Disubstituted N-[(1-Ethyl-2-Pyrrolidinyl)Methyl]-6-Methoxysalicylamides
    作者:De Paulis,Tomas; Kumar,Yatendra; Johansson,Lars; Raemsby,Sten; Hall,Haakan; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:1986 卷标:29(1) 页码:61-9]

    84225-94-5 = 84225-95-6
    反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; -20 °C; 2 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; 30 Min,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; < Ph 7
    标题:An Improved Synthesis Of Pet Dopamine D2 Receptors Radioligand [11C]Raclopride
    作者:Fei,Xiangshu; Mock,Bruce H.; Degrado,Timothy R.; Wang,Ji-Quan; Glick-Wilson,Barbara E.; Et Al
    参考文献:Synthetic Communications 日期:2004 卷标:34(10) 页码:1897-1907]

    114812-34-9 + 32541-62-1 = 84225-95-6
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran1.2 Reagents: Triethylamine Solvents: Dichloromethane1.3 Reagents: Boron Tribromide
    标题:N-Fluoroalkylated And N-Alkylated Analogs Of The Dopaminergic D-2 Receptor Antagonist Raclopride
    作者:Lannoye,G. S.; Moerlein,Stephen M.; Parkinson,D.; Welch,M. J.
    参考文献:Journal Of Medicinal Chemistry 日期:1990 卷标:33(9) 页码:2430-7]

    84225-94-5 = 84225-95-6
    反应条件:1.1 Reagents: Hydrochloric Acid,Boron Tribromide Solvents: Dichloromethane
    标题:Synthesis Of [methoxy-3H]- And [methoxy-11C]-Labeled Raclopride. Specific Dopamine-D2 Receptor Ligands
    作者:Ehrin,Erling; Gawell,Lars; Hoegberg,Thomas; De Paulis,Tomas; Stroem,Peter
    参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1987 卷标:24(8) 页码:931-40
📜3,5-Dichloro-2,6-Dimethoxybenzoyl Chloride置于三溴化硼体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 雷氯必利
参考文献:An Improved Synthesis Of Pet Dopamine D2 Receptors Radioligand [11C]Raclopride
标题:An Improved Synthesis Of Pet Dopamine D2 Receptors Radioligand [11C]Raclopride
摘要:An Improved Synthesis Of [c-11]Raclopride Is Reported. The Precursor Desmethyl-Raclopride Was Synthesized From 3,5-Dichloro-2,6-Dimethoxybenzoic Acid And (S)-(-)-2-Aminoethyl-1-Ethylpyrrolidine Via A Straightforward,Four-Step Synthetic Approach With 29% Overall Chemical Yield. [c-11]Raclopride Was Prepared By O-[c-11]Methylation Of The Precursor With [c-11]Methyl Triflate And Purification With A Semi-Preparative HPLC Method In 20-34% Radiochemical Yield,Based On [c-11]Methyl Bromide,Decay Corrected To End Of Bombardment (Eob).
DOI:10.1081/scc-120034174

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专利信息


专利号:US-2022009919-A1
优先权日:2009-12-17
标题:Preparation of n-monofluoroalkyl compounds
发明人：WILLIAMS LORENZO; KEILEN GUNNAR; HAUGAN JARLE ANDRE
权利人:GE HEALTHCARE LTD
摘要:The present invention relates to an improved synthesis of N-monofluoroalkyl tropanes using fluoroalkyl iodide. The invention also provides the use of such method to prepare the non-radioactive tropane intermediate FP-CIT, and its subsequent conversion to the 123 I-labelled radiopharmaceutical DaTSCANâ„¢ ( 123 I-ioflupane). Also provided is the use of fluoroalkyl iodide in the alkylation method of the invention.

专利号:US-6749830-B2
优先权日:2001-01-31
标 题:Method for the synthesis of radiolabeled compounds
发明人：WILSON ALAN ALEXANDER; GARCIA ARMANDO FRANCISCO; JIN LI; HOULE SYLVAIN JOSEPH
权利人:CAMH
摘要:The present invention relates to a new method for radiolabeling chemical compounds. The new method attains the goals of simplicity, high radiochemical yields, speed, versatility, and automation. An HPLC injection loop on an HPLC injection valve is loaded with a solution of precursor and the radiolabeling reagent is passed through the loop. The contents of the loop are then quantitatively injected onto the HPLC column for purification. Radiochemical yields are equal to or superior to conventional solution methods in all cases, even though no heat need be applied. Since no vials, transfer lines, cooling, heating, or sealing valves are required, no transfer losses occur, yields are high, and clean-up is minimal. This “loop methodâ€? is ideal for the preparation of radiolabeled compounds, in particular those prepared from [ 11 C]-iodomethane.

专利号:US-6872716-B2
优先权日:2000-09-11
标题:Antipsychotic sulfonamide-heterocycles, and methods of use thereof
发明人：WU XINHE; AQUILA BRIAN M; SHAO LIMING; RADEKE HEIKE; CUNY GREGORY D; HAUSKE JAMES R; XIE ROGER L
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds comprising a sulfonamide moiety to treat diseases, afflictions or maladies caused at least in part by abnormal activity of one or more GPCRs or ligand-gated ion channels. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds comprising a sulfonamide moiety, and the screening of those libraries for biological activity, e.g., in animal models of psychosis.

专利号:US-2002155063-A1
优先权日:2001-01-31
标 题 :Method for the synthesis of radiolabeled compounds

专利号:US-2007160574-A1
优先权日:2000-04-12
标题 :Design of CXC chemokine analogs for the treatment of human diseases
发明人：MERZOUK AHMED; SALARI HASSAN
权利人:MERZOUK AHMED; SALARI HASSAN
摘要:The present invention generally relates to the design, preparation, derivation, and use of mimetics of CXC chemokines (CXCL1-CXCL17) in the prevention, treatment, and ameliorization of a wide variety of diseases and disorders. Generally speaking, this invention is directed to the design, synthesis, and use of chemokine analogs which bind to CXC chemokine receptors CXCR1-CXCR7, such that the analogs can be designed to affect the activity of the receptor, either as an agonist or an antagonist. The analogs can be useful for treating a wide variety of diseases and disorders, and can also serve as an adjunct to the treatment of a variety of diseases and disorders.

专利号:EP-4630405-A1
优先权日:2022-12-06
标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

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参考文献:10.1038/mp.2011.86
摘要:Wang GJ, Smith L, Volkow ND, Telang F, Logan J, Tomasi D, Wong CT, Hoffman W, Jayne M, Alia-Klein N, Thanos P, Fowler JS. Decreased dopamine activity predicts relapse in methamphetamine abusers. Mol Psychiatry. 2012 Sep;17(9):918–25.
参考文献:10.1016/j.neuropharm.2011.06.025
摘要:Orrú M, Quiroz C, Guitart X, Ferré S. Pharmacological evidence for different populations of postsynaptic adenosine A2A receptors in the rat striatum. Neuropharmacology. 2011 Oct;61(5-6):967–74. doi: 10.1016/j.neuropharm.2011.06.025.
参考文献:10.1007/s00415-011-6168-9
摘要:Kono S, Ouchi Y, Terada T, Suzuki M, Yagi S, Miyajima H. Combined FDG and raclopride PET study in a case of ALS with the R521C FUS gene mutation. J Neurol. 2012 Feb;259(2):367–9. doi: 10.1007/s00415-011-6168-9.
参考文献:10.1016/j.neuroimage.2011.07.002
摘要:Normandin MD, Schiffer WK, Morris ED. A linear model for estimation of neurotransmitter response profiles from dynamic PET data. NeuroImage. 2012 Feb;59(3):2689–99. doi: 10.1016/j.neuroimage.2011.07.002.
参考文献:10.1017/s146114571100109x
摘要:Sutton LP, Rushlow WJ. The dopamine D2 receptor regulates Akt and GSK-3 via Dvl-3. Int J Neuropsychopharmacol. 2012 Aug;15(7):965–79. doi: 10.1017/s146114571100109x.
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