专利号:US-11059835-B2 优先权日:2014-08-15 标 题 :Synthesis of cephalosporin compounds 发明人:WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON 权利人:MERCK SHARP & DOHME 摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.
专利号:EP-3180347-B1 优先权日:2014-08-15 标 题:Synthesis of cephalosporin compounds
专利号:US-2019263831-A1 优先权日:2014-08-15 标 题:Synthesis of cephalosporin compounds
专利号:US-2017275300-A1 优先权日:2014-08-15 标题 :Synthesis of cephalosporin compounds
专利号:US-2020385404-A1 优先权日:2014-08-15 标 题 :Synthesis of cephalosporin compounds
专利号:WO-2016025839-A1 优先权日:2014-08-15 标题:Synthesis of cephalosporin compounds
参考标题: Synthesis Of Cephalosporin Compounds Synthèse De Composés De Céphalosporine 摘要:Provided Herein Is A Method For The Synthesis Of Cephalosporin Antibiotic Compounds Comprising A Palladium-Catalyzed Coupling Reaction. Provided Herein Are Methods For The Synthesis Of Cephalosporin Compounds Of Formula (I) Employing A Palladium-Catalyzed Alkylation Reaction, As Well As Compositions Related To The Same. In An Aspect, Provided Herein Is A Method For Preparing A Compound Of Formula (II), Or A Salt Thereof, Comprising The Step Of Admixing, E.G., Reacting, A Compound Of Formula (III), Or A Salt Thereof, With A Nucleophile (Nuc) In The Presence Of Reagents Comprising: (A) A Palladium Source; And (B) A Palladium-Binding Ligand, To Form A Compound Of Formula (II), Or A Salt Thereof.
合成参考文献
摘要:Friestad, G. K., Science of Synthesis, (2009) 40, 331.