CAS: 656233-53-3; (11Ar)-10,11,12,13-Tetrahydrodiindeno[7,1-De:1',7'-Fg][1,3,2]Dioxaphosphocin-5-Phenoxy

该化合物是一种复杂的有机化合物,其特征是独特的多环结构,将磷和氧都纳入二氧磷磷-磷-磷-酚框架;该化合物具有一个双循环系统,有助于其稳定性和潜在再活动;苯氧化合物的存在增强了其在有机溶剂中的溶性,并可能影响其生物活动;11aR的指定表明的立体化学学表明,该物质的具体空间安排能够严重影响化合物的特性和相互作用;这些化合物由于在药物开发中的潜在应用和作为功能材料,往往对材料科学和药用化学感兴趣;然而,有必要对其物理和化学特性进行详细研究,例如熔点,沸点和再活性,以便充分了解其在各种环境中的行为.

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(R)-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol phenol

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    专利信息


    专利号:US-11059835-B2
    优先权日:2014-08-15
    标 题 :Synthesis of cephalosporin compounds
    发明人:WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON
    权利人:MERCK SHARP & DOHME
    摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.

    专利号:EP-3180347-B1
    优先权日:2014-08-15
    标 题:Synthesis of cephalosporin compounds

    专利号:US-2019263831-A1
    优先权日:2014-08-15
    标 题:Synthesis of cephalosporin compounds

    专利号:US-2017275300-A1
    优先权日:2014-08-15
    标题 :Synthesis of cephalosporin compounds

    专利号:US-2020385404-A1
    优先权日:2014-08-15
    标 题 :Synthesis of cephalosporin compounds

    专利号:WO-2016025839-A1
    优先权日:2014-08-15
    标题:Synthesis of cephalosporin compounds

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    主要参考文献

    参考标题: Synthesis Of Cephalosporin Compounds Synthèse De Composés De Céphalosporine
    摘要:Provided Herein Is A Method For The Synthesis Of Cephalosporin Antibiotic Compounds Comprising A Palladium-Catalyzed Coupling Reaction. Provided Herein Are Methods For The Synthesis Of Cephalosporin Compounds Of Formula (I) Employing A Palladium-Catalyzed Alkylation Reaction, As Well As Compositions Related To The Same. In An Aspect, Provided Herein Is A Method For Preparing A Compound Of Formula (II), Or A Salt Thereof, Comprising The Step Of Admixing, E.G., Reacting, A Compound Of Formula (III), Or A Salt Thereof, With A Nucleophile (Nuc) In The Presence Of Reagents Comprising: (A) A Palladium Source; And (B) A Palladium-Binding Ligand, To Form A Compound Of Formula (II), Or A Salt Thereof.

    合成参考文献


    摘要:Friestad, G. K., Science of Synthesis, (2009) 40, 331.
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