CAS: 62669-70-9; 3,6-Diamino-9-(2-(Methoxycarbonyl)Phenyl)Xanthylium Chloride

上下游产品

methanol rhodamine 110 chloride Dihydrorhodamine 123Dihydrorhodamine 123 4'-iododihydrorhodamine 123

二氢罗丹明123 以 丙酮作为反应溶剂,获得 Rhodamin 123
参考文献:Does Perthionitrite (Ssno-) Account For Sustained Bioactivity Of No A (Bio)Chemical Characterization
标题:Does Perthionitrite (Ssno-) Account For Sustained Bioactivity Of No A (Bio)Chemical Characterization
摘要:Hydrogen Sulfide (H2S) And Nitric Oxide (No) Are Important Signaling Molecules That Regulate Several Physiological Functions. Understanding The Chemistry Behind Their Interplay Is Important For Explaining These Functions. The Reaction Of H2S With S-Nitrosothiols To Form The Smallest S-Nitrosothiol,Thionitrous Acid (Hsno),Is One Example Of Physiologically Relevant Cross-Talk Between H2S And Nitrogen Species. Perthionitrite (Ssno-) Has Recently Been Considered As An Important Biological Source Of No That Is Far More Stable And Longer Living Than Hsno. In Order To Experimentally Address This Issue Here,We Prepared Ssno-By Two Different Approaches,Which Lead To Two Distinct Species: Ssno-And Dithionitric Acid [Hon(S)S/Hsn(O)S]. (H)S2No Species And Their Reactivity Were Studied By N-15 Nmr,Ir,Electron Paramagnetic Resonance And High-Resolution Electrospray Ionization Time-Of-Flight Mass Spectrometry,As Well As By X-Ray Structure Analysis And Cyclic Voltammetry. The Obtained Results Pointed Toward The Inherent Instability Of Ssno-In Water Solutions. Ssno-Decomposed Readily In The Presence Of Light,Water,Or Acid,With Concomitant Formation Of Elemental Sulfur And Hno. Furthermore,Ssno-Reacted With H2S To Generate Hsno. Computational Studies On (H)Ssno-Provided Additional Explanations For Its Instability. Thus,On The Basis Of Our Data,It Seems To Be Less Probable That Ssno-Can Serve As A Signaling Molecule And Biological Source Of No. Ssno-Salts Could,However,Be Used As Fast Generators Of Hno In Water Solutions.
Doi:10.1021/Acs.Inorgchem.5B00831

专利信息

专利号:US-7541165-B2
优先权日:2001-10-30
标 题 :Molecular detection systems utilizing reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
权利人:RIBOMED BIOTECHNOLOGIES INC
摘要:The present invention provides methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators; using a chain terminator to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase. In one aspect, the invention provides a method for detecting a target protein, DNA or RNA by generating multiple detectable RNA oligoribonucleotides by abortive transcription.

专利号:US-11851651-B2
优先权日:2017-06-19
标 题 :Automated methods for scalable, parallelized enzymatic biopolymer synthesis and modification using microfluidic devices
发明人：BANAL JAMES; BERLEANT JOSEPH DON; SHEPHERD TYSON; BATHE MARK
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Methods for the automated template-free synthesis of user-defined sequence controlled biopolymers using microfluidic devices are described. The methods facilitate simultaneous synthesis of up to thousands of uniquely addressed biopolymers from the controlled movement and combination of regents as fluid droplets using microfluidic and EWOD-based systems. In some forms, biopolymers including nucleic acids, peptides, carbohydrates, and lipids are synthesized from step-wise assembly of building blocks based on a user-defined sequence of droplet movements. In some forms, the methods synthesize uniquely addressed nucleic acids of up to 1,000 nucleotides in length. Methods for adding, removing and changing barcodes on biopolymers are also provided. Biopolymers synthesized according to the methods, and libraries and databases thereof are also described. Modified biopolymers, including chemically modified nucleotides and biopolymers conjugated to other molecules are described.

专利号:US-2004054162-A1
优先权日:2001-10-30
标 题:Molecular detection systems utilizing reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
摘要:The present invention provides methods for detecting the presence of a target molecule by the use of nucleotide analogs containing moieties that enable detection. Such analogs may be incorporated into nucleic acids. In one embodiment, nucleotide analogs are used in a process generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators or chain terminators to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase.

专利号:US-2014378538-A1
优先权日:2011-12-14
标 题:Methods of responding to a biothreat
发明人：BANCEL STEPHANE
权利人:MODERMA THERAPEUTICS INC
摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-6869973-B2
优先权日:2000-06-22
标题:Nitrosated and nitrosylated taxanes, compositions and methods of use
发明人：GARVEY DAVID S; LETTS L GORDON; LIN CHIA-EN; RICHARDSON STEWART K; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The present invention also provides novel compositions comprising at least one taxane and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The compounds and compositions of the present invention can also be bound to a matrix. The present invention also provides methods for treating or preventing cardiovascular diseases and disorders, autoimmune diseases, pathological conditions resulting from abnormal cell proliferation, polycystic kidney disease, inflammatory disease, preserving organs and/or tissues or to inhibit wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis, by administering nitrosated and/or nitrosylated taxane or parent taxanes in combination with nitric oxide donors that are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions.