CAS: 621-54-5; 3-(3-Hydroxyphenyl)Propanoic Acid

该化合物是一种有机化合物,其特点是苯丙酸和碳酸性功能组,其特点是一种有机化合物,其3-(3-3-Hydroxy)丙酸基质在3位置上具有一种丙烯酸脊椎,具有氢氧代苯组,有助于其化学反应和潜在的生物活动;该化合物一般是白色至白色晶状固体,可溶于水和酒精等极地溶剂,在标准条件下具有中等稳定性;其分子结构允许氢结合,可影响其溶性及其与生物系统的互动;3-(3-Hydroxy)丙基苯基丙酸在各个领域,包括制药和材料科学领域都具有兴趣,因为它有可能成为更复杂的分子的建筑块块及其在生物化学途径中的作用;此外,它可能表现出抗氧化性特性,使其成为健康和营养研究的主体;适当的处理和储存与许多有机酸一样,对于确保安全和化合物的完整性至关重要.

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上下游产品

CAS号14755-02-3 3-羟基肉桂酸; 间羟基肉桂酸 | CAS号540-38-5 4-碘苯酚 | CAS号10516-71-9 3-(3-甲氧基苯基)丙酸 | CAS号2373-80-0 3,4-(亚甲二氧)肉桂酸 | CAS号1257-08-5 表儿茶素没食子酸酯 | CAS号490-46-0 表儿茶素(EC) | CAS号331-39-5 咖啡酸 | CAS号37850-17-2 3-(2-Carboxy-3-... | CAS号99-61-6 间硝基苯甲醛 | CAS号57668-34-5 3-[3-(Benzyloxy... | CAS号3470-49-3 5-羟基-1-茚酮 | CAS号6968-35-0 7-羟基-1-茚酮 | CAS号193151-11-0 3-氰基-苯丙酸甲酯 | CAS号28945-89-3 3-(3-乙氧基苯基)丙酸 | CAS号61389-68-2 3-(3-羟苯基)丙酸甲酯 | CAS号10516-71-9 3-(3-甲氧基苯基)丙酸 | CAS号1424-74-4 3-(3-羟丙基)-苯酚 | CAS号34708-60-6 3-(3-羟基苯基)丙酸乙酯 | CAS号66192-02-7 (2-溴-5-甲氧基苯基)丙酸

合成工艺路线路线简述

    📜3,4-Methylenedioxy-Trans-Cinnamic Acid置于sodium Hydroxide,Aluminum Nickel体系中,化学反应生成 3-(3-羟基苯基)丙酸
    参考文献:Reductions With Nickel-Aluminum Alloy And Aqueous Alkali.1 Part V. Rupture Of The Methylenedioxyl Bridge
    标题:Reductions With Nickel-Aluminum Alloy And Aqueous Alkali.1 Part V. Rupture Of The Methylenedioxyl Bridge
    摘要:
    DOI:10.1021/jo01179A013

    海关参考信息

    专利信息


    专利号:US-11746364-B2
    优先权日:2018-01-17
    标题 :Enzymatic synthesis of kavalactones and flavokavains
    发明人:PLUSKAL TOMÃ?S; Weng jing-ke
    权利人:WHITEHEAD INST BIOMEDICAL RES
    摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

    专利号:US-9453037-B2
    优先权日:2011-07-28
    标 题 :Methylphenidate-prodrugs, processes of making and using the same
    发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
    权利人:KEMPHARM INC; KEMPHARM INC
    摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

    专利号:US-2005244935-A1
    优先权日:1999-06-25
    标题:Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport
    发明人:POMPEJUS MARKUS; KROGER BURKHARD; SCHRODER HARTWIG; ZELDER OSKAR; HABERHAUER GREGOR
    权利人:BASF AG
    摘要:Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.

    专利号:US-12350398-B2
    优先权日:2017-04-28
    标 题:Biodegradable bone glue
    发明人:XUE TENG; LUPPI GIANLUIGI; SAVIETTO NATALIA RUGGERI; BOWMAN III HOWARD K; SPENCER PAUL JOSEPH; KARAU ANDREAS; Zhang jian-feng; LIZIO ROSARIO; Jones Marshall Scott
    权利人:EVONIK OPERATIONS GMBH
    摘要:The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.

    专利号:US-3850911-A
    优先权日:1960-09-22
    标题:Steroid synthesis
    发明人:HUGHES G; SMITH H
    权利人:HUGHES G; SMITH H
    摘要:1. A CHEMICAL COMPOUND HAVING A CYCLOPENTANOPHENANTHRENE CARBON-CARBON SKELETON CONTAINING AT LEAST 19 AND UP TO A MAXIMUM OF 40 CARBON ATOMS AND IN WHICH AT LEAST B AND THE C RING ARE AT LEAST PARTIALLY HYDROGENATED, INCLUDING A NUCLEUS SELECTED FROM THE GROUP CONSISTING OF SATURATED AND UNSATURATED GONANE AND 8ISOGONANE NUCLEI HAVING UP TO A MAXIMUM OF FIVE (5) DOUBLE BONDS AND HAVING A PART THEREOF IN THE 13-POSITION F MONOVALENT POLYCARBON ALKYL RADICAL HAVING 2 TO ABOUT 16 CARBON ATOMS, SAID RINGS AND THE 13 AND OTHER POSITIONS OF THE NUCLEUS BEING IDENTIFIED ACCORDING TO STEROID NOMENCLATURE.

    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Iveta Najmanová, Et Al. Flavonoid Metabolite 3‐(3‐hydroxyphenyl)Propionic Acid Formed By Human Microflora Decreases Arterial Blood Pressure In Rats. Wiley Online Library. Volume60, Issue5. May 2016.

    合成参考文献


    参考文献:10.1016/j.bbrc.2006.06.009
    摘要:Lee S, Ko J, Kang H, Lee Y. Coupled expression of MhpE aldolase and MhpF dehydrogenase in Escherichia coli. Biochemical and Biophysical Research Communications. 2006 Aug;346(3):1009–15. doi: 10.1016/j.bbrc.2006.06.009.
    参考文献:10.1038/s41598-018-24978-9
    摘要:Beauclercq S, Nadal-Desbarats L, Hennequet-Antier C, Gabriel I, Tesseraud S, Calenge F, Le Bihan-Duval E, Mignon-Grasteau S. Relationships between digestive efficiency and metabolomic profiles of serum and intestinal contents in chickens. Scientific Reports. 2018 Apr 27;8(1):6678. doi: 10.1038/s41598-018-24978-9.
    参考文献:10.1021/jf049404r
    摘要:Ward NC, Croft KD, Puddey IB, Hodgson JM. Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic Acid, an important metabolite of proanthocyanidins in humans. J Agric Food Chem. 2004 Aug 25;52(17):5545–9. doi: 10.1021/jf049404r.
    参考文献:10.1002/mnfr.200500144
    摘要:Labib S, Hummel S, Richling E, Humpf HU, Schreier P. Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds. Mol Nutr Food Res. 2006 Jan;50(1):78–86. doi: 10.1002/mnfr.200500144.
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