📜3,4-Methylenedioxy-Trans-Cinnamic Acid置于sodium Hydroxide,Aluminum Nickel体系中,化学反应生成 3-(3-羟基苯基)丙酸 参考文献:Reductions With Nickel-Aluminum Alloy And Aqueous Alkali.1 Part V. Rupture Of The Methylenedioxyl Bridge 标题:Reductions With Nickel-Aluminum Alloy And Aqueous Alkali.1 Part V. Rupture Of The Methylenedioxyl Bridge 摘要: DOI:10.1021/jo01179A013
专利号:US-11746364-B2 优先权日:2018-01-17 标题 :Enzymatic synthesis of kavalactones and flavokavains 发明人:PLUSKAL TOMÃ?S; Weng jing-ke 权利人:WHITEHEAD INST BIOMEDICAL RES 摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.
专利号:US-9453037-B2 优先权日:2011-07-28 标 题 :Methylphenidate-prodrugs, processes of making and using the same 发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB 权利人:KEMPHARM INC; KEMPHARM INC 摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
专利号:US-2005244935-A1 优先权日:1999-06-25 标题:Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport 发明人:POMPEJUS MARKUS; KROGER BURKHARD; SCHRODER HARTWIG; ZELDER OSKAR; HABERHAUER GREGOR 权利人:BASF AG 摘要:Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.
专利号:US-12350398-B2 优先权日:2017-04-28 标 题:Biodegradable bone glue 发明人:XUE TENG; LUPPI GIANLUIGI; SAVIETTO NATALIA RUGGERI; BOWMAN III HOWARD K; SPENCER PAUL JOSEPH; KARAU ANDREAS; Zhang jian-feng; LIZIO ROSARIO; Jones Marshall Scott 权利人:EVONIK OPERATIONS GMBH 摘要:The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.
专利号:US-3850911-A 优先权日:1960-09-22 标题:Steroid synthesis 发明人:HUGHES G; SMITH H 权利人:HUGHES G; SMITH H 摘要:1. A CHEMICAL COMPOUND HAVING A CYCLOPENTANOPHENANTHRENE CARBON-CARBON SKELETON CONTAINING AT LEAST 19 AND UP TO A MAXIMUM OF 40 CARBON ATOMS AND IN WHICH AT LEAST B AND THE C RING ARE AT LEAST PARTIALLY HYDROGENATED, INCLUDING A NUCLEUS SELECTED FROM THE GROUP CONSISTING OF SATURATED AND UNSATURATED GONANE AND 8ISOGONANE NUCLEI HAVING UP TO A MAXIMUM OF FIVE (5) DOUBLE BONDS AND HAVING A PART THEREOF IN THE 13-POSITION F MONOVALENT POLYCARBON ALKYL RADICAL HAVING 2 TO ABOUT 16 CARBON ATOMS, SAID RINGS AND THE 13 AND OTHER POSITIONS OF THE NUCLEUS BEING IDENTIFIED ACCORDING TO STEROID NOMENCLATURE.
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
[参考文献]: Iveta Najmanová, Et Al. Flavonoid Metabolite 3‐(3‐hydroxyphenyl)Propionic Acid Formed By Human Microflora Decreases Arterial Blood Pressure In Rats. Wiley Online Library. Volume60, Issue5. May 2016.
合成参考文献
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