2-溴丙酸乙酯置于四丁基溴化铵 盐酸,Sodium Azide体系中,用 苯 作为反应溶剂,化学反应 8.0H,反应生成 Dl-丙氨酸乙酯盐酸盐 参考文献:One-Pot Transformation Of Alkyl Bromides Into Primary Amines Via The Staudinger Reaction 标题:One-Pot Transformation Of Alkyl Bromides Into Primary Amines Via The Staudinger Reaction 摘要: DOI:10.1055/s-1985-31155
专利号:CN-105732631-A 优先权日:2016-01-28 标 题 :N9 vinyl purine and its synthesis method, and its method of synthesizing multi-substituted chiral azacyclic nucleoside analogs as raw materials
专利号:WO-2013153539-A1 优先权日:2012-04-13 标 题:Tricyclic compounds as tec kinase inhibitors 发明人:CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; KHAIRATKAR-JOSHI NEELIMA; SHAH DAISY MANISH 权利人:GLENMARK PHARMACEUTICALS SA 摘要:The present invention is directed to tricyclic compounds of formula (I) as Tec kinase inhibitors, in particular ITK (interleukin-2 inducible tyrosine kinase) inhibitors. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by ITK.