CAS: 52712-05-7; 2,2',3,4,5,5',6-Heptachlorobiphenyl

该化合物是多氯联苯(PCB)家族的成员,该家族由以其环境持久性和潜在毒性而闻名的合成有机化学品组成.PCB 185的特点是结构复杂,含有多氯原子附着于联苯,有助于其化学稳定性和疏水性.该化合物通常用于工业用途,包括电容器和变压器中的电离液,以及各种其他电气设备.由于其疏水特性,PC 185往往在环境和生物有机体中积累,从而引起人们对其生物累积性和潜在健康影响的关切,包括内分泌干扰和致癌性.许多国家都实施了管制措施,限制多氯联苯(包括PC 185)的使用和释放,因为其对环境的影响和相关的健康风险.妥善处理和处置对于减轻与该化学品有关的风险至关重要.

英文名称2,2',3,4,5,5',6-Heptachlorobiphenyl
中文名称2,2',3,4,5,5',6-七氯联苯
IUPAC名称1,2,3,4,5-pentachloro-6-(2,5-dichlorophenyl)benzene
其它别名2,2',3,4,5,5',6-Heptachlorobiphenyl; 2,3,4,5,6,2',5'-Heptachlorobiphenyl
CAS编号52712-05-7
MFCD编号:MFCD00152521
FDA UNII编号:E4GON8Y94S
分子式:C12H3Cl7分子量:395.32
产品CID: 2496376
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
InChIKey: PYZHTHZEHQHHEN-UHFFFAOYSA-N
1S/C12H3Cl7/c13-4-1-2-6(14)5(3-4)7-8(15)10(17)12(19)11(18)9(7)16/h1-3H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

2,5 dichloroaniline pentachlorobenzene 1,2,3,4,8-pentachlorodibenzofuran

合成工艺路线路线简述

📜2,5-二氯苯胺,五氯苯置于亚硝酸异戊酯体系中,化学反应生成 2,2',3,4,5,5',6-七氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4