CAS: 5061-21-2; 2-Bromo-4-Butanolide

相似化合物

108-30-5 58917-25-2 33693-67-3

上下游产品

CAS号96-48-0 γ-丁内酯 | CAS号52412-07-4 2,4-二溴代酰溴 | CAS号10491-63-1 3-prop-2-enylox... | CAS号96-48-0 γ-丁内酯 | CAS号191096-51-2 2-(2-HYDROXYETH... | CAS号547-65-9 α-亚甲基-γ-丁内酯 | CAS号42023-17-6 3-[(dimethylami... | CAS号497-23-4 2(5H)-呋喃酮 | CAS号2907-85-9 Phosphonic acid... | CAS号83-40-9 邻甲基水杨酸 | CAS号6305-38-0 α-氨基-γ-丁内酯氢溴酸盐 | CAS号72492-12-7 螺佐呋酮

γ-丁内酯置于溴,三溴化磷体系中,化学反应 25.0H,以65%的收率获得产物α-溴-γ-丁内酯
参考文献:α-二乙氧基磷酰基-γ-内酯的碱催化乙醇解:环丙烷羧酸盐的简便合成
标题:α-二乙氧基磷酰基-γ-内酯的碱催化乙醇解:环丙烷羧酸盐的简便合成
摘要:通过在四氢呋喃中用乙醇钠处理取代的 α-二乙氧基磷酰基-Y-内酯,已经立体选择性地制备了一系列烷基和烯基环丙烷羧酸乙酯.
DOI:10.1055/s-2005-917116

专利信息

专利号:US-2024425890-A1
优先权日:2022-02-11
标 题:Process for the synthesis of alpha-methylene-gamma-butyrolactone
发明人：TADEN ANDREAS; BECK HORST; MYRTOLLARI KAMELA; KOURIST ROBERT; NIGL ANDREA
权利人:HENKEL AG & CO KGAA
摘要:The present application provides a process for the preparation of α-methylene-γ-butyrolactone, said process comprising the steps of:a) acetylating the C1-hydroxyl group of isoprenol to yield isoprenyl acetate;b) forming 4-acetoxy-2-methylene-butan-1-ol from said isoprenyl acetate by whole cell biotransformation, said step comprising:i) contacting a cell (CB) with a culture medium containing said isoprenyl acetate or with a culture medium contiguous with an organic phase containing said isoprenyl acetate under conditions that enable the cell to form 4-acetoxy-2-methylene-butan-1-ol from isoprenyl acetate; and,ii) optionally isolating the resultant 4-acetoxy-2-methylene-butan-1-ol, wherein said cell (CB) exhibits activity of at least one alkane monooxygenase enzyme which catalyzes the formation of 4-acetoxy-2-methylene-butan-1-ol from isoprenyl acetate;c) oxidizing said 4-acetoxy-2-methylene-butan-1-ol to yield 4-acetoxy-2-methylene butyric acid; and,d) converting said 4-acetoxy-2-methylene butyric acid to α-methylene-γ-butyrolactone by hydroxylysis to γ-hydroxy-α-methylenebutyric acid and subsequent cyclization of said γ-hydroxy-α-methylenebutyric acid.

专利号:US-7902383-B2
优先权日:2006-05-29
标 题 :Production method of heterocyclic mercapto compound
发明人：YOROZUYA SHINICHI; AOKI HIDEMASA
权利人:SHOWA DENKO KK
摘要:A method of the invention industrially produces heterocyclic mercapto compounds useful as raw materials or intermediates in the synthesis of medicaments or pesticides, or as permanent wave agent, with a high yield and high productivity using easily available starting materials. A heterocyclic mercapto compound represented by Formula (1) (wherein X represents any structure of —O—, —S—, —NH—, and —NR 1 —; R 1 represents any of an alkyl group, alkoxy group and alkoxyalkyl group each having 1 to 6 carbon atoms; Y represents an oxygen atom, a sulfur atom or —NR 2 —; R 2 represents a hydrogen atom or alkyl group having 1 to 6 carbon atoms; and Z 1 represents a divalent organic residue having at least one mercapto group) is produced by reacting a metal sulfide or a metal hydrosulfide with a compound represented by Formula (2) (wherein X and Y are as defined in Formula (1); and Z 2 represents a divalent organic residue having at least one halogen group) in the presence of a solvent at a pH of 7.0 to 11.0.

专利号:WO-2025024697-A1
优先权日:2023-07-27
标 题:Intermediates for synthesizing exatecan mesylate
发明人：GOEDDEL DAVID; WALKER JAMES; WRIGHT AUSTIN; REDFERN LOUIS
权利人:SIGMA ALDRICH CO LLC
摘要:Intermediates useful in the preparation of exatecan mesylate and related compounds. Further provided are methods for preparing these compounds. Also provided is an improved, scalable synthesis of exatecan mesylate using the provided intermediates. The synthesis of exatecan mesylate utilizes a convergent approach, involving fewer steps and utilizing fewer reagents and increasing efficiency.

专利号:EP-2883866-A1
优先权日:2012-08-13
标题 :INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-beta-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES

专利号:WO-2014027658-A1
优先权日:2012-08-13
标题 :INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES

专利号:MX-2015001935-A
优先权日:2012-08-13
标 题 :INTERMEDIARY FOR SYNTHESIS OF 1- (2-DEOXI-2-FLUORO-4-TIO-BETA-D-A RABINOFURANOSIL) CITOSINE, INTERMEDIARY FOR SYNTHESIS OF TIONUCLEOSIDE AND METHODS TO PRODUCE THESE INTERMEDIARIES.