CAS: 503-49-1; 3-Hydroxy-3-Methylpentanedioic Acid

相似化合物

625-08-1 7564-64-9 72060-94-7

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CAS号7564-64-9 3-甲基-1,3,5-戊三醇 | CAS号89622-82-2 ditert-butyl 3-... | CAS号7440-44-0 活性炭 | CAS号25201-40-5 1,1-二烯丙基乙醇 | CAS号674-26-0 DL-甲瓦龙酸内酯 | CAS号88205-12-3 7-O-[hydrogen (... | CAS号34695-32-4 3-羟基-3-甲基戊二酸酐 | CAS号81943-18-2 4-methyl-4-trim... | CAS号73489-84-6 3-羟基-3-甲基-戊二酸二乙酯 | CAS号476-56-2 9,10-Anthracene... | CAS号34695-32-4 3-羟基-3-甲基戊二酸酐 | CAS号2387-23-7 N,N’-二环己基脲 | CAS号481-74-3 大黄酚 | CAS号19115-49-2 D-甲瓦龙酸酯 | CAS号87894-65-3 3-ACETOXY-3-MET... | CAS号7564-64-9 3-甲基-1,3,5-戊三醇 | CAS号674-26-0 DL-甲瓦龙酸内酯 | CAS号73489-84-6 3-羟基-3-甲基-戊二酸二乙酯 | CAS号150-97-0 3,5-二羟基-3-甲基戊酸

甲瓦龙酸内酯置于硝酸体系中,化学反应 4.0H,以57%的收率获得产物3-羟基-3-甲基谷氨酸
参考文献: Polymers Prepared From Mevalonolactone And Derivatives[fr] Polymères Préparés à Partir De La Mévalonolactone Et De Ses Dérivés
标题: Polymers Prepared From Mevalonolactone And Derivatives[fr] Polymères Préparés à Partir De La Mévalonolactone Et De Ses Dérivés
摘要:本文描述了从生物基化合物中衍生的聚合物前体化合物(又称聚合物构建模块),特别是生物基美伐酮内酯及其相关衍生物.通过氧化,这些生物基前体可以被反应反应生成(不饱和的)聚酯,聚酯多元醇和聚酰胺的构建模块,以及环氧酯和ω-烯基酯的前体.通过还原,这些生物基前体可以被反应反应生成(不饱和的)聚酯,聚酯多元醇,聚碳酸酯的构建模块,以及环氧醚和ω-烯基醚的前体.通过亲核环开和/或酰胺化,这些生物基前体可以被反应反应生成聚酯多元醇的构建模块,聚氨酯的扩链剂,或聚酯酰胺.

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-9051555-B2
优先权日:2009-07-17
标题 :Methods and composition for isoprenoid diphosphate synthesis
发明人：NOEL JOSEPH P; DELLAS NIKKI M
权利人:NOEL JOSEPH P; DELLAS NIKKI M; SALK INST FOR BIOLOGICAL STUDI
摘要:Provided herein are methods and compositions relating to the synthesis of isoprenoid diphosphates using a mutated isopentenyl phosphate kinase.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-9102961-B2
优先权日:2009-03-11
标 题 :Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
发明人：BAYNES BRIAN M; GEREMIA JOHN MICHAEL; LIPPOW SHAUN M
权利人:CELEXION LLC
摘要:Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.

专利号:US-6149924-A
优先权日:1998-07-20
标题 :Composition for enhancing lipid production, barrier function, hydrogen peroxide neutralization, and moisturization of the skin
发明人：PAUL HARBHAJAN S
权利人:BIOMED RES & TECHNOLOGIES INC
摘要:Increased production of skin lipids, increased barrier function, hydrogen peroxide neutralization, prevention of loss of the natural moisturizing factor from the stratum corneum and moisturization of the skin is provided by a topically applicable composition which includes one or more components selected from the group consisting of branched chain amino acids, derivatives of branched chain amino acids and mixtures thereof, which one or more components are capable of being catabolized in epidermal cells to form lipid precursors for epidermal lipid synthesis. The composition can also include one or more enzyme activators which increase the rate of catabolism of the one or more components.