CAS: 50-47-5; Desipramine

上下游产品

CAS号50-49-7 米帕明 | CAS号113-52-0 丙咪嗪盐酸盐 | CAS号58-28-6 去甲丙咪嗪盐酸盐 | CAS号51018-29-2 (4S)-2,2,3,4r-t... | CAS号123618-06-4 (4S,5R)-3,4-dim... | CAS号102339-76-4 (2R)-3c,4-dimet... | CAS号65100-48-3 3-(10,11-Dihydr... | CAS号19009-26-8 3-(10,11-dihydr... | CAS号81256-33-9 3-(10,11-dihydr... | CAS号50-49-7 米帕明 | CAS号1066-35-9 二甲基一氯硅烷 | CAS号23047-25-8 Lopramine | CAS号2095-95-6 didesipramine | CAS号5227-91-8 N-hydroxydesipramine

📜米帕明置于magnesium Chloride Pooled Human Liver Microsomes,Tris Buffer,还原型辅酶ii(Nadph)四钠盐体系中,化学反应生成 地昔帕明
参考文献:Chip-Based P450 Drug Metabolism Coupled To Electrospray Ionization-Mass Spectrometry Detection
标题:Chip-Based P450 Drug Metabolism Coupled To Electrospray Ionization-Mass Spectrometry Detection
摘要:本文介绍了一种基于芯片的 P450 体外代谢检测方法,该方法与 Esi-Ms 和 Esi-Ms/ms 检测相结合.芯片由环烯烃聚合物通过热压印工艺制成.试剂溶液通过熔融石英毛细管引入芯片,毛细管与两个注射器相连,流速由注射泵控制.本文所述的初步实验采用了芯片外形式的小型商用保护柱,用于在进行 Esi-Ms 分析之前对酶反应产物进行脱盐和浓缩.该系统既用于得出丙咪嗪向地西普胺的 P450 生物转化的迈克尔斯常数(km),也用于确定 Cyp2C19 介导的这一反应的化学抑制剂(氨甲环丙胺)的 Ic50 值.结果表明,在环烯烃聚合物芯片通道内 4μl 容积内的反应动力学结果与文献报道的使用传统测定法的结果一致.利用人体肝脏微粒体进行了上述反应,并通过 Esi-Ms 对代谢物进行了检测,结果表明基于芯片的 P450 反应可用于代谢物筛选研究和 P450 抑制测定.随后,多孔整体柱被集成到芯片中,在芯片上以集成的方式执行反应混合物净化过程,这是进行 Esi-Ms 检测所必需的.微型整体固相萃取柱是通过紫外引发聚合反应在芯片内就地制备的.使用该集成系统获得的结果表明,可以在一个直接与 Esi-Ms 检测相结合的微量反应室中进行 P450 酶反应,并且所需的 Hlm 蛋白少于 4 μg.
DOI:10.1021/ac030249+

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-6271379-B1
优先权日:2000-03-08
标题:Intermediates useful for the synthesis of huperzine A
发明人：TUECKMANTEL WERNER; KOZIKOWSKI ALAN P
权利人:UNIV GEORGETOWN
摘要:Intermediates useful for the synthesis of huperzine A represented by the structures below, n and methods for their synthesis, wherein: n R 1 is lower alkyl, benzyl, or substituted benzyl; n X is a suitable leaving group; n Y is an electron withdrawing group that can subsequently be converted into an amino group; n one broken line is present as a carbon—carbon bond and the other broken line is absent, where the broken line forms an unconjugated carbon—carbon double bond, which double bond may be endocyclic whereby n is 3 or the double bond may be exocyclic whereby n is 2.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:US-2012100555-A1
优先权日:2009-06-29
标题 :Synthesis And Use Of Fluorophore-Tagged Antimalarials
发明人：LEAR MARTIN JAMES; TAN KEVIN SHYONG WEI
权利人:LEAR MARTIN JAMES; TAN KEVIN SHYONG WEI
摘要:This invention includes a fluorophore-tagged antimalarial represented by the following structural formula (1) or a salt thereof. This invention relates to the synthesis of fluorophore-tagged antimalarials and describes the synthesis of a fluorophore-tagged antimalarial. These fluorophore-tagged antimalarials can be used to image live cells to determine the location of the antimalarial in the cell, identify drug resistance and growth related pathways in Plasmodium isolates, identify new drug targets and chemo-sensitizers to reverse drug resistance.