CAS: 4871-97-0; (3S,3As,5S,6R,8As)-5-Isopropyl-3-Methyl-8-Methyleneoctahydro-6H-3A,6-Epoxyazulen-6-Ol
该化合物是一种在突变中发现的自然形成的松增素,其主要优势在于其强效抗氧化特性和调节炎症途径的潜力. 研究表明,它可能应用于抗炎化合物的开发,为各行业提供了具有巨大治疗潜力的独特化学特征.
- 英文名称(3S,3As,5S,6R,8As)-5-Isopropyl-3-Methyl-8-Methyleneoctahydro-6H-3A,6-Epoxyazulen-6-Ol
- 中文名称莪术醇
- IUPAC名称(3S,3aS,5S,6R,8aS)-5-isopropyl-3-methyl-8-methyleneoctahydro-6H-3a,6-epoxyazulen-6-ol
- 其它别名( -)-Curcumol, Analytical Standard; (1S,2S,5S,8R,9S)-2-Methyl-6-Methylidene-9-Propan-2-Yl-11-Oxatricyclo[6.2.1.01,5]Undecan-8-Ol; ( -)-Curcumol; 6H-3A,6-Epoxyazu
- CAS编号4871-97-0
- MFCD编号:MFCD00272163
- FDA UNII编号:9190RTN07X
- 分子式:C15H24O2分子量:236.35
- 产品CID: 1479012
- 产品分类生物化工 → 中草药成分
物理性质
- 熔点141-142 °C
- 沸点334.5±42.0 °C at 760 mmHg
- 闪点134.7±22.1 °C
- 密度1.1±0.1 g/cm3
- pKa:13.02±0.60(预测)
- PSA:29.46
- LogP:3.25
- 折射率1.526
- 蒸汽压0.0±1.6 mmHg at 25°C
- 溶解性DMSO:55.67(Max Conc. mg/mL);235.54(Max Conc. Mm) DMF:20.0(Max Conc. mg/mL);84.62(Max Conc. Mm) Ethanol:28.5(Max Conc. mg/mL);120.58(Max Conc. Mm)
- 外观形态白色至淡黄色固体
- 储存条件在惰性气体(氮气或氩气)下 2–8 °C
- 产品应用该化合物用于一种乳胶化敏化剂,以强化乳胶酸性药物的抗胃效应.研究表明,它能促进HCC细胞在体外的血吸附性,抑制HCC肿瘤在体内的生长.它与 LENVATINIB 结合,可以诱发更具有自动性细胞的形成,从而增强LENVATINIB对肝细胞肿瘤细胞的抗肿瘤效应.
MSDS等安全信息
上下游产品
CAS号13657-68-6 莪术二酮合成工艺路线路线简述
📜(3S,3As,5S,6S,8As)-5-Isopropyl-3-Methyl-8-Methylene-octahydro-Azulene-3A,6-Diol置于吡啶,Chromium(Vi) Oxide体系中,化学反应生成 莪术醇
参考文献:Structure Of Curcumol
标题:Structure Of Curcumol
摘要:从zedoary(姜科植物)中提取出一种新的倍半萜类化合物,即姜黄素,其经验公式为c15H24O2. 姜黄素含有亚甲基基团和半缩醛系统. 通过脱氢反应,瓜伊纳碳骨架形成s-愈创木烯(iv). 姜黄素被臭氧氧化为降酮(ix),后者被转化为酸(x)和内酯(xii). 对这些衍生物的光谱研究和其他证据表明,姜黄素可用公式i(r=h)表示.
DOI:10.1248/cpb.14.1241
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-115785040-B
优先权日:2022-11-03
标题 :Chiral synthesis of active natural products curcumene and isogermfurolactone
专利号:CN-115785040-A
优先权日:2022-11-03
标题:Chiral synthesis method of active natural products curzerene and isogermacrofuryl lactone
专利号:CN-114560868-A
优先权日:2022-02-18
标题:Synthesis method of curcumenol marked by biotin
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Wang G, Yue Z, Yin G, Zhu L, Zhou W, Sun R, Bi T, Zhao L, Bian Y, Tang D. Curcumol Targets the VHL/HIF-1α Axis to Suppress Glycolysis-Driven Progression in Colorectal Cancer. Cancers (Basel). 2025 Sep 14;17(18):3000. doi: 10.3390/cancers17183000.
2: Xie J, Zhu Y, Bai H, Song Z, Qiu S, Xie Y, Wan S. Multi-omics analysis of the anti-cancer effects of curcumol in endometrial carcinoma. Front Pharmacol. 2025 Jul 3;16:1565959. doi: 10.3389/fphar.2025.1565959.
3: Luo C, Zheng ZG, Zeng MQ, Xu H, Yu XM, Sun D, He DJ. Curcumol targets the FTO/MAFG-AS1 axis to alleviate diabetic retinopathy via epigenetic remodeling and nanodelivery-based microenvironment modulation. World J Diabetes. 2025 Jun 15;16(6):107017. doi: 10.4239/wjd.v16.i6.107017.
合成参考文献
参考文献:10.31083/ph.2014.3194
摘要:Kong LM, Xu SY, Hu HH, Zhou H, Jiang HD, Yu LS, Zeng S. Identification of CYP2C19 inhibitors from phytochemicals using the recombinant human enzyme model. Pharmazie. 2014 May 01;69(5). doi: 10.31083/ph.2014.3194.
参考文献:10.1016/j.intimp.2014.05.021
摘要:Wang H, Wang Y, Jiang X, Wang Z, Zhong B, Fang Y. The molecular mechanism of curcumol on inducing cell growth arrest and apoptosis in Jurkat cells, a model of CD4⁺ T cells. Int Immunopharmacol. 2014 Aug;21(2):375–82. doi: 10.1016/j.intimp.2014.05.021.
参考文献:10.1007/s11655-021-3310-0
摘要:Zheng Y, Wang L, Wang J, Liu L, Zhao T. Effect of Curcumol on NOD-Like Receptor Thermoprotein Domain 3 Inflammasomes in Liver Fibrosis of Mice. Chinese Journal of Integrative Medicine. 2021 Jul 28;28(11):992–9. doi: 10.1007/s11655-021-3310-0.
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