CAS: 4708-04-7; 1-Dichlorophosphorylpropane

上下游产品

dibutyl propylphosphonate propane dichloropropylphosphine phosphorus trichloride Propanthiophosphonsaeuredichlorid propyl-phosphonic acid diallyl ester S-ethyl ester-O-(4-nitro-phenyl ester)propyl-thiophosphonic acid S-ethyl ester-O-(4-nitro-phenyl ester) Propyl-phosphonic acid 2-isopropyl-5-methyl-cyclohexyl ester methyl ester

丙基膦酸置于氯化亚砜体系中,用 甲苯 作为反应溶剂,化学反应 4.0H,以90%的收率获得产物1-丙基二氯化磷
参考文献:一种环状丙基膦酸酐的制备方法
标题:一种环状丙基膦酸酐的制备方法
摘要:本发明属于有机合成技术领域,尤其涉及一种环状丙基膦酸酐的制备方法,以丙基膦酸和醋酸酐为反应物制得丙基焦膦酸,以丙基膦酸和氯化亚砜为反应物制得丙基膦酰氯,将丙基焦膦酸与丙基膦酰氯进一步反应制得环状丙基膦酸酐.本发明制备得到的环状丙基膦酸酐的反应收率高,总收率高达68‑72%,成本低,纯度高,滴定纯度大于99.5%,游离酸含量小于100Ppm,多聚体含量低,能够满足锂电池添加剂的使用.本发明的制备方法简单,安全环保高效,原料廉价易得,市场前景广阔,适合规模化生产.

专利信息

专利号:US-2015099864-A1
优先权日:2013-10-08
标题:Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.

专利号:WO-2015053980-A1
优先权日:2013-10-08
标 题 :Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.

专利号:US-4041111-A
优先权日:1975-03-04
标题:Phosphonate monoesters and method of preparation
发明人：KELLY SUSAN J; BUTLER LARRY G
权利人:PURDUE RESEARCH FOUNDATION
摘要:Synthesis of phosphonate monoesters, as well as the use of such monoesters as substrates for enzymes which normally hydrolyze phosphodiester linkages, and a method for distinguishing between Type I and Type II phosphodiesterase enzymes using such monoesters as substrates are disclosed herein. Monoesters of phosphonic acids are prepared by the displacement of chloride from an appropriate phosphonic acid dichloride by a phenol or alcohol with pyridine as the solvent, reacting the same and then removing the solvent, after which the remaining ester chloride and dichloride are hydrolyzed by addition of water. The acid and ester are then separated and the acid-free ester is taken up in a polar organic solvent and precipitated as a salt by the addition of aqueous base, with the product then being filtered, washed with fresh acetone, dried and then stored until needed. The thus formed phosphonate monoesters are shown to be effective for use as substrate for phosphodiesterase of the Type I specificity and are shown to be ineffective for use as substrates for phosphodiesterase of the Type II specificity. The type of phosphodiesterase is therefore determined by the amount of activity against phosphonate monoesters.

专利号:EP-0500254-A1
优先权日:1991-02-13
标题 :Process for the synthesis of nucleoside-5'-alkylphosphonates
发明人：YAMAGAMI HIDETOMI; MORI YOSHIKAZU
权利人:TSUMURA & CO
摘要:A nucleoside-5'-alkylphosphonate is synthesized by reacting a nucleoside, optionally having protected hydroxyl groups at the 2'- and 3'-positions, with an alkylphosphonic halide, or reacting a nucleoside in which the hydroxyl groups at the 2'- and 3'-positions are protected with an alkylphosphonic acid or alkylphosphonic halide in the presence of a condensation agent.

专利号:CA-2061089-A1
优先权日:1991-02-13
标题:Process for the synthesis of nucleoside-5' -alkylphosphonates

专利号:CN-103214519-B
优先权日:2013-04-02
标 题 :Synthesis process of O-ethyl-S-n-propyl-(3-ethyl-2-cyanoimine-1-imidazole) phosphate