CAS: 35852-58-5; 2-Chloro-4-(Trifuloromethyl)Phenol

该化合物是一个有机化合物,其特点是芳香结构,包括一个以氯原子,氢氧基组和三个氟原子替代的苯环,该化合物一般是无色的黄色液体,以其相对较高的稳定性和低波动性而闻名;氢氧基组的存在具有一些极地特性,而三氟甲基组则加强其亲耳性,并能够影响其在各个溶剂中的再活性和溶性;该化合物经常用于化学合成,并用作生产药品和农用化学品中的中间体;此外,由于氯和氟,该化合物可能具有独特的特性,例如对降解的抗药性增加以及与生物系统的具体互动;在处理和储存准则方面,应参考安全数据表,因为这可能给健康和环境带来风险.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号402-45-9 4-(三氟甲基)苯酚 | CAS号400091-57-8 2-[2-chloro-4-(... | CAS号64635-55-8 potassium salt ... | CAS号328-84-7 3,4-二氯三氟甲苯 | CAS号75-65-0 叔丁醇 | CAS号455-19-6 对三氟甲基苯甲醛 | CAS号454-81-9 2-氨基-4-三氟甲基苯酚 | CAS号50594-66-6 三氟羧草醚 | CAS号50594-67-7 三氟羧草醚甲酯 | CAS号78068-81-2 2-氨基-6-氯-4-(三氟甲基)苯酚 | CAS号653578-34-8 2-chloro-1-(3-i... | CAS号42874-01-1 nitrofluorfen | CAS号50594-65-5 5-[2-chloro-5-(...

合成工艺路线路线简述

    对三氟甲基苯甲醛置于二异丁胺,磺酰氯,间氯过氧苯甲酸体系中,化学反应生成3-氯-4-羟基三氟甲苯
    参考文献:(2R)-2-Methylchromane-2-Carboxylic Acids: Discovery Of Selective Pparα Agonists As Hypolipidemic Agents
    标题:(2R)-2-Methylchromane-2-Carboxylic Acids: Discovery Of Selective Pparα Agonists As Hypolipidemic Agents
    摘要:A Sar Study Was Conducted On Chromane-2-Carboxylic Acid Toward Selective Ppar Alpha Agonisim. As A Result,Highly Potent,And Selective Ppar Alpha Agonists Were Discovered. The Optimized Compound 43 Exhibited Robust Lowering Of Total Cholesterol Levels In Hamster And Dog Animal Models. (C) 2005 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Bmcl.2005.05.028

    海关参考信息

    专利信息


    专利号:US-4402804-A
    优先权日:1982-05-17
    标题 :Electrolytic synthesis of aryl alcohols, aryl aldehydes, and aryl acids
    发明人:JACKSON PATRICIA J
    权利人:PPG INDUSTRIES INC
    摘要:Disclosed is a method of synthesizing compounds chosen from the group consisting of benzyl alcohol, benzaldehyde, benzoic acid, phenoxy benzyl alcohol, phenoxy benzaldehyde, phenoxy benzoic acid, and mixtures thereof by providing a composition of a current carrying component, such as a fluoroborate salt or a tetraethylammonium salt, a solvent, and a methyl aryl compound in contact with an anode and cathode. The solvent is reduced at the cathode and the methyl substituted aryl at the anode whereby to form product. According to an alternative exemplification of the invention, the anode and cathode are separated by a permionic membrane and a source of oxygen is provided in contact with the cathode and the permionic membrane.

    专利号:US-4450308-A
    优先权日:1980-02-08
    标 题:Process for the preparation of trifluoromethylphenyl oxyphenyl ether compounds
    发明人:FOERSTER HEINZ; PRIESNITZ UWE
    权利人:BAYER AG
    摘要:New process for the preparation of known trifluoromethylphenyl oxyphenyl ether compounds of the formula ##STR1## wherein X stands for fluorine, chlorine or bromine and n R for moieties, substituted if desired, of the series alkyl, alkenyl and alkinyl, n by reacting 1,2-dihalogen-4-trifluoromethylbenzenes of the formula ##STR2## in which X and X 1 independently of one another stand for fluorine, chlorine or bromine, n with phenols of the formula ##STR3## in which R has the meaning given above, and basic alkali or alkaline earth compounds or with the salts formed from the phenols of formula (III) and the basic alkali or alkaline earth compounds, in the presence of diluents at temperatures between 60° and 120° C. n The compounds of the formula (I) are intermediates for the synthesis of herbicides.

    专利号:US-4621160-A
    优先权日:1983-06-23
    标题 :Process for the chlorination of aromatic derivatives
    发明人:DESBOIS MICHEL; DISDIER CAMILLE
    权利人:RHONE POULENC SPEC CHIM
    摘要:A process for the chlorination of aromatic derivatives. The aromatic derivative is reacted with chlorine gas in liquid hydrofluoric acid. The products obtained are useful as intermediates for the synthesis of compounds having a plant-protecting or pharmaceutical activity.

    专利号:CN-110357773-A
    优先权日:2019-07-08
    标题 :Synthesis of 3-chloro-4-hydroxybenzoic acid

    专利号:CN-102030655-B
    优先权日:2010-10-21
    标题:Synthesis method of diphenyl ether derivate, combined production method of oxyfluorfen and acifluorfen and synthesis method of oxyfluorfen

    专利号:CN-102030655-A
    优先权日:2010-10-21
    标题 :Synthesis method of diphenyl ether derivate, combined production method of oxyfluorfen and acifluorfen and synthesis method of oxyfluorfen
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    主要参考文献

    参考标题:Cascade Palladium Catalysis: A Predictable And Selectable Regiocontrolled Synthesis OfN-Arylbenzimidazoles
    作者:Nathan T. Jui,Stephen L. Buchwald |发布日期:2013.10.25
    摘要:Choice: The Palladium‐catalyzed Cascade Reaction Of 2‐chloroaryl Sulfonates With Arylamine And Amide Nucleophiles Provides Direct Access To N‐arylbenzimidazoles. This Strategy Selectively Produces The Heterocycles Based On Chemoselective Oxidative Addition. 2‐chloroaryl Triflates (Tf) Produce One Regioisomer And The Corresponding 2‐chloroaryl Mesylates (Ms) Deliver The Other In A Selectable Manner.

    合成参考文献


    参考文献:10.1007/s40003-024-00740-8
    摘要:Majid S, Ahmad KS, Malik MA, Karami AM. Exploring Oxyfluorfen's Environmental Fate: Soil Affinity, Persistence, Degradation Dynamics and Ecological Implications. Agric Res. 2024 Aug 02;13(4):763–78. doi: 10.1007/s40003-024-00740-8.
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