CAS: 35474-99-8; 1-Monoarachidin

📜花生四烯酸 在 草酰氯,B-氯-1,2-苯二酚硼烷体系中,用 二氯甲烷作为反应溶剂,反应 30.0H,获得 2-Arachidonyl-Glycerol
参考文献:大麻素受体的内源性配体2-花生四烯酰基甘油的简化化学和放射化学合成
标题:大麻素受体的内源性配体2-花生四烯酰基甘油的简化化学和放射化学合成
摘要:内源性大麻素已成为一类新型的脂质介体,在中枢神经系统和周围神经系统中起着多种作用.几项研究已确定2-花生四烯酰基甘油(2-Ag)是大麻素受体的主要内源性激动剂.在此,报告了2-Ag的化学合成及其tri标记衍生物的合成.这些未标记和放射性标记的化合物是揭示2-Ag在各种细胞和组织中的某些代谢途径和生物活性的合适工具.
Doi:10.1016/J.Tetlet.2004.02.045

专利信息

专利号:US-2023346952-A1
优先权日:2015-09-22
标题:Cannabinoid glycoside prodrugs and methods of synthesis
发明人：ZIPP BRANDON J; HARDMAN JANEE’ M; BROOKE ROBERT T; DEUTSCHER TYREL R
权利人:GRAPHIUM BIOSCIENCES INC
摘要:The present invention provides tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs and pharmaceutical compositions comprising these compounds, and their use for the site-specific delivery of tetrahydrocannabinol or cannabidiol. Also provided are processes for the preparation of purified tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs.

专利号:US-11207414-B2
优先权日:2015-09-22
标 题 :Cannabinoid glycoside prodrugs and methods of synthesis
发明人：ZIPP BRANDON J; HARDMAN JANEE M; BROOKE ROBERT T
权利人:GRAPHIUM BIOSCIENCES INC
摘要:The present invention relates to cannabinoid glycoside prodrugs suitable for site- and tissue-specific delivery of cannabinoid molecules. The present invention also relates to methods of forming the cannabinoid glycoside prodrugs through glycosyltransferase mediated glycosylation of cannabinoid molecules.

专利号:US-2018264122-A1
优先权日:2015-09-22
标 题 :Cannabinoid Glycoside Prodrugs and Methods of Synthesis

专利号:CN-108136208-B
优先权日:2015-09-22
标 题:Cannabinoid glycoside prodrugs and methods of synthesis

专利号:US-2022168428-A1
优先权日:2015-09-22
标题 :Cannabinoid glycoside prodrugs and methods of synthesis