CAS: 35166-78-0; Magnesium,Methanidylcyclohexane,Bromide

该化合物是属于grignard试剂类的有机磁性化合物.这些试剂具有高度反应性的特点,特别是对于电极具有高度反应性,因为存在碳-镁结合物.这种特定化合物具有附于镁原子的环己甲基混合物的特点,有助于其独特的再活动特征.通常,在有机合成中使用 Grignard试剂,形成碳-碳结,促成复杂分子的形成.溴(环己甲基)镁对湿气和空气敏感,需要在惰性大气中处理,例如氮或丙贡,以防止分解.还已知,它与水和丙酸溶剂,释放碳氢化合物和形成镁氢氧化物形成有强烈反应.该化合物的再活性使得它的价值在各种合成应用中具有价值,包括碳基化合物和其他功能性化学混合物的钚添加剂.

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ECHA物质C&L通报

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    专利信息


    专利号:US-5856497-A
    优先权日:1995-12-11
    标题 :Asymmetric synthesis of α-cycloalkylalkyl substituted methanamines
    发明人：ROTH GREGORY; LANDI JOHN
    权利人:BOEHRINGER INGELHEIM PHARMA
    摘要:This invention relates to process for asymmetrically producing enantiomerically pure α-cycloalkylalkyl substitututed methanamines from α-pinene. One key step of the process of this invention utilizes the oxidation product of α-pinene, hydroxy pinanone, as a chiral auxiliary to direct the stereoselective alkylation of the corresponding ketimine. This invention also relates to key intermediates useful in the processes referred to herein.

    专利号:JP-H10502059-A
    优先权日:1994-06-17
    标 题 :Synthesis of condurit epoxides and aziridines and their use in the synthesis of advanced disaccharides

    专利号:EP-0781750-A2
    优先权日:1995-12-11
    标 题:Asymmetric synthesis of alpha-cycloalkylalkyl substituted methanamines

    专利号:US-11267824-B2
    优先权日:2017-08-17
    标 题:Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
    发明人：BOSS CHRISTOPH; BUR DANIEL; CREN SYLVAINE; KIMMERLIN THIERRY; LOTZ-JENNE CARINA; POTHIER JULIEN; TIDTEN-LUKSCH NAOMI
    权利人:IDORSIA PHARMACEUTICALS LTD
    摘要:The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in inter alia cancer is disclosed.

    专利号:CA-2192417-A1
    优先权日:1995-12-11
    标 题:Asymmetric synthesis of ó-cycloalkylalkyl substituted methanamines

    专利号:JP-H09221472-A
    优先权日:1995-12-11
    标题:Asymmetric synthesis of alpha-cycloalkyl-substituted methanamines

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    合成参考文献


    摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 77.
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