CAS: 34633-09-5; 3-(4-Iodophenyl)Acrylic Acid

上下游产品

CAS号621-82-9 肉桂酸 | CAS号16004-15-2 对碘溴苄 | CAS号141-82-2 丙二酸 | CAS号15164-44-0 4-碘苯甲醛 | CAS号2393-18-2 4-胺桂皮酸 | CAS号501-52-0 3-苯丙酸 | CAS号1643-29-4 对碘苯丙酸

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.