CAS: 26163-07-5; 5-Bromo-N,N-Dimethylpyridin-2-Amine

该化合物是一种有机化合物,其特征是其环,这是一种六人组成的芳香热循环,含有一个氮原子;在环的5位置上存在一个溴原子,会引入一种卤素替代成分,这可能影响化合物的反活动性和物理特性;在2位置上附着的N,N-二甲基-1-yl组表明存在一种二甲基氨功能组,可以增强化合物的基质和核分裂性;该化合物一般无色,其形态取决于黄色液体或固体,在极有机溶剂中溶解,其用途可包括有机合成,作为药品的建筑块或农业化学配方.应当参考安全数据,因为卤化化合物可能表现出不同程度的毒性和环境影响.适当的处理和储存条件对于确保使用期间的安全至关重要.

英文名称5-Bromo-N,N-Dimethylpyridin-2-Amine
中文名称5-溴-2-二甲基氨基吡啶
IUPAC名称5-bromo-N,N-dimethylpyridin-2-amine
其它别名2-二甲氨基-5-溴吡啶; (5-Bromo-Pyridin-2-yl)-Dimethylamine
CAS编号26163-07-5
MFCD编号:MFCD00099486
EINECS号:963-275-4
分子式:C7H9BrN2分子量:201.06
产品CID: 1231246
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: XIMCGXXYEMOWQP-UHFFFAOYSA-N
InChI=1S/C7H9BrN2/c1-10(2)7-4-3-6(8)5-9-7/h3-5H,1-2H3
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

相似化合物

227939-01-7 209959-28-4 1060801-39-9

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi,Xn
风险等级Irritant
安全声明H303+H313+H333
危险类别码22

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 5-Bromo-2-(Dimethylamino)Pyridine 主要起始原料 5-Bromo-2-Chloropyridine And Dimethylamine Hydrochloride
(文献来源)合成步骤主要原料 5-Bromo-2-Chloropyridine 和 Dimethylamine Hydrochloride

📜2-二甲氨基吡啶置于四丁基溴化铵,Lithium Perchlorate体系中,用溶剂黄146,乙腈用作溶剂,化学反应 8.0H,反应生成5-溴-2-二甲基氨基吡啶
参考文献:导向基团可在温和条件下实现吡啶的电化学选择性间溴化
标题:导向基团可在温和条件下实现吡啶的电化学选择性间溴化
摘要:在不使用催化剂和氧化剂的情况下,开发了一种简便且可持续的电化学溴化方案.通过引入定位基团,吡啶衍生物的区域选择性可以在被控制的元利用廉价且安全的溴盐在室温下位上.以 28-95% 的收率获得了多种溴化吡啶衍生物,并且该反应可以很容易地以克级规模进行.通过结合安装和去除导向基团,可以验证吡啶间溴化的概念.
Doi:10.1021/acs.Joc.1C00923

海关参考信息

2933310010-吡啶
2921199090-其他无环单胺
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2009275616-A1
优先权日:2008-04-30
标题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:US-6268378-B1
优先权日:1997-12-17
标题 :Integrin receptor antagonists
发明人：DUGGAN MARK E; MEISSNER ROBERT S; PERKINS JAMES J
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the vitronectin receptors alphavbeta3 and/or alphavbeta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, viral disease, and tumor growth.

专利号:CN-108689923-B
优先权日:2018-07-11
标题 :Novel green and practical synthesis method of N, N-dimethylpyridine compound