CAS: 17408-16-1; 1-(3-Nitrophenyl)Propan-1-One

上下游产品

CAS号93-55-0 苯丙酮 | CAS号121-92-6 间硝基苯甲酸 | CAS号619-24-9 间硝基苯腈 | CAS号34911-51-8 2-溴-3'-氯苯丙酮 | CAS号34841-35-5 间氯苯丙酮 | CAS号21762-25-4 2-(3-Amino-2,4,... | CAS号23279-54-1 2-[3-[acetyl(et... | CAS号29067-72-9 2-[3-(butanoyla... | CAS号23217-82-5 2-[2,4,6-Triiod... | CAS号23279-53-0 2-(3-Acetylamin... | CAS号2524-81-4 3-丙基苯胺 | CAS号618-95-1 3-硝基苯甲酸甲酯 | CAS号1197-05-3 1-(3-氨基苯基)丙-1-酮

苯丙酮置于硝酸体系中,化学反应 1.0H,以52%的收率获得3-硝基苯丙酮
参考文献:高价碘试剂的立体选择性酮重排
标题:高价碘试剂的立体选择性酮重排
摘要:描述了在原酸酯存在下碘(III)介导的芳基酮重排的第一个立体选择性形式.反应产物α-芳基化酯是生物活性化合物(如布洛芬)合成中非常有用的中间体.使用基于手性乳酸的碘(III)试剂,产品选择性高达73% Ee.
Doi:10.1002/chem.201603022

专利信息

专利号:US-8729308-B2
优先权日:2009-12-01
标 题:Process for the preparation of tapentadol and intermediates thereof
发明人：MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO
权利人:MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO; EUTICALS SPA
摘要:The present invention refers to a new process for the synthesis of tapentadol comprising the quantitative resolution of the racemic mixture (V) to obtain the stereoisomer of (S)-3-(dimethylamino)-2-methyl-1-(3-nitrophenyl)-propan-1-one (VII) according to the Scheme 2 below n nusing the (2R,3R)—O,O′-dibenzoyltartaric chiral acid wherein said resolution is quantitative.n n The present invention also refers to some intermediate compounds of the new synthesis process of tapentadol.

专利号:US-2004110957-A1
优先权日:2002-12-05
标 题 :Process for the synthesis of an antiviral compound
发明人：WILKEN JOERG; NERENZ FRANK; KANSCHIK-CONRADSEN ANDREAS
权利人:HONEYWELL INT INC
摘要:In a process comprising synthesizing pyranes including [R—(R*,R*)]-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide the present invention comprises the improvements comprising: (a) providing a racemic mixture of 3-hydroxy-3-(2-phenylethyl)-hexanoate ethyl acetate by reacting said 1-phenyl-hexan-3-one with ethylbromoacetate under Reformatsky conditions; and (b) separating (R)-3-hydroxy-3-(2-phenylethyl)-hexanoic acid in enantiomeric excess by saponification and reverse resolution of the racemate of step (a) to produce a resolved product. In addition, the present invention comprises a reverse resolution process for separating an enantiomer from a mixture of enantiomers.

专利号:US-2006287397-A1
优先权日:2002-04-26
标 题:Dl-hydroxy-alkyl-phenylamides having anticonvulsive activity
发明人：MEZA TOLEDO SERGIO E
权利人:MEZA TOLEDO SERGIO E
摘要:New anticonvulsant compounds were synthesized and they include the compounds: DL-2-hydroxy-2-(3′,5′-bistrifluoromethylphenyl)butyramide, DL-2-hydroxy-2-(4′-trifluoromethylphenyl)butyramide, DL-2-hydroxy-2-(3′,4′-dichlorophenyl)butyramide, DL-2-hydroxy-2-(3′-bromophenyl)butyramide, DL-2-hydroxy-2-(4′-bromophenyl)butyramide, DL-2-hydroxy-2-(3′-nitrophenyl)butyramide, DL-3-hydroxy-3-(3′,4′-dichlorophenyl)pentanamide, DL-3-hydroxy-3-(4′-bromophenyl)pentanamide, DL-4-hydroxy-4-(3′,4′-dichlorophenyl) hexanamide and DL-4-hydroxy-4-(4′-bromophenyl)hexanamide. They have a significant anticonvulsant activity against pentylenetetrazol-induced seizures as well as unexpected differences in anticonvulsant activity respect those of the non-halogenated compounds. The invention further provides methods for the synthesis of the DL-hydroxy-alkyl-phenyl amides as exemplified in the examples.