4-羟基苯甲腈置于盐酸,氢溴酸,溴三氧化物体系中,用 水 用作溶剂,以99%的收率获得溴苯腈 参考文献: A Process For The Eco-Friendly Preparation Of 3,5-Dibromo-4-Hydroxybenzonitrile[fr] Procédé Pour La Préparation Respectueuse De L'Environnement De 3,5-Dibromo-4-Hydroxybenzonitrile 标题: A Process For The Eco-Friendly Preparation Of 3,5-Dibromo-4-Hydroxybenzonitrile[fr] Procédé Pour La Préparation Respectueuse De L'Environnement De 3,5-Dibromo-4-Hydroxybenzonitrile 摘要:一种高纯度的3,5-二溴-4-羟基苯甲腈(溴氧草酰)已从4-羟基苯甲腈使用环保的溴化试剂制备而成,该试剂由2:1的摩尔比的溴化物和溴酸盐在水酸性介质中制备而成,无需催化剂,在常温条件下无需任何工作步骤.该产品3,5-二溴-4-羟基苯甲腈通过气相色谱分析获得,产率为91-99%,熔点为189-191°C,纯度超过99%,无需任何纯化过程.
专利号:US-7510852-B2 优先权日:2002-10-18 标题:Biosynthetic genes and host cells for the synthesis of polyketide antibiotics and method of use 发明人:ROYER MONIQUE; GABRIEL DEAN W; FRUTOS ROGER; ROTT PHILIPPE 权利人:CIRAD; UNIV FLORIDA 摘要:Three gene clusters that together encode albicidin biosynthesis, the complete gene DNA sequences, and the deduced protein sequences for the enzymes and methods for using the DNA sequences are disclosed and discussed as well as methods for plant protection and creating new antibiotics. The novel Albicidin family of antibiotics is disclosed and their structure deduced.
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:WO-2024256370-A1 优先权日:2023-06-13 标 题 :Synthesis of glufosinate using an amidase-based process 发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.
专利号:WO-2025050656-A1 优先权日:2023-09-04 标 题 :Method and biomaterial for total biosynthesis of paclitaxel precursor substance baccatin iii, and use 发明人:YAN JIANBIN; JIANG BIN; SUN YAPING; HUANG SANWEN 权利人:AGRICULTURAL GENOMICS INST AT SHENZHEN CHINESE ACADEMY OF AGRICULTURAL SCIENCES SHENZHEN BRANCH GUAN; AGRICULTURAL GENOMICS INST CHINESE ACADEMY OF AGRICULTURAL SCIENCES 摘要:A method and a biomaterial for the total biosynthesis of a key paclitaxel precursor substance baccatin III, and the use. The biological enzyme composition used in the method comprises taxane 9α-hydroxylase (T9αH) and taxane C4-C20 oxetane-forming enzyme (TOT). The core ingredients of the biosynthetic pathway of baccatin III are identified, and an artificial synthesis route for baccatin III is constructed, which pave the way for the efficient development of a green and low-carbon production pathway for taxane products such as paclitaxel by means of synthetic biology.
专利号:US-2025120400-A1 优先权日:2021-12-10 标题:Synthesis of glufosinate using a hydantoinase-based process 发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.
专利号:US-8487159-B2 优先权日:2008-04-28 标题:Production of polyhydroxybutyrate in switchgrass 发明人:SOMLEVA MARIYA N; SNELL KRISTI D; BEAULIEU JULIE; PEOPLES OLIVER P; GARRISON BRADLEY; PATTERSON NII 权利人:SOMLEVA MARIYA N; SNELL KRISTI D; BEAULIEU JULIE; PEOPLES OLIVER P; GARRISON BRADLEY; PATTERSON NII; METABOLIX INC 摘要:Transgenic plants, plant material, and plant cells for synthesis of polyhydroxyalkanoates, preferably poly(3-hydroxybutyrate) (also referred to a as PHB) are provided. Preferred plants that can be genetically engineered to produce PHB include plants that do not normally produce storage products such as oils and carbohydrates, and plants that have a C 4 NAD-malic enzyme photosynthetic pathway. Such plants also advantageously produce lignocellulosic biomass that can be converted into biofuels. An exemplary plant that can be genetically engineered to produce PHB and produce lignocellulosic biomass is switchgrass, Panicum virgatum L. A preferred cultivar of switchgrass is Alamo. Other suitable cultivars of switchgrass include but are not limited to Blackwell, Kanlow, Nebraska 28, Pathfinder, Cave-in-Rock, Shelter and Trailblazer.
1: European Food Safety Authority (EFSA); Arena M, Auteri D, Barmaz S, Bellisai G, Brancato A, Brocca D, Bura L, Byers H, Chiusolo A, Court Marques D, Crivellente F, De Lentdecker C, De Maglie M, Egsmose M, Erdos Z, Fait G, Ferreira L, Goumenou M, Greco L, Ippolito A, Istace F, Jarrah S, Kardassi D, Leuschner R, Lythgo C, Magrans JO, Medina P, Miron I, Molnar T, Nougadere A, Padovani L, Parra Morte JM, Pedersen R, Reich H, Sacchi A, Santos M, Serafimova R, Sharp R, Stanek A, Streissl F, Sturma J, Szentes C, Tarazona J, Terron A, Theobald A, Vagenende B, Verani A, Villamar-Bouza L. Peer review of the pesticide risk assessment of the active substance bromoxynil (variant evaluated bromoxynil octanoate). EFSA J. 2017 Jun 14;15(6):e04790. doi: 10.2903/j.efsa.2017.4790. 2: Halbach K, Aulhorn S, Lechtenfeld OJ, Lecluse M, Leippe S, Reemtsma T, Seiwert B, Wagner S, König J, Luckenbach T. Zebrafish Oatp1d1 Acts as a Cellular Efflux Transporter of the Anionic Herbicide Bromoxynil. Chem Res Toxicol. 2022 Feb 21;35(2):315-325. doi: 10.1021/acs.chemrestox.1c00371. Epub 2022 Jan 6. Anastassiadou M, Arena M, Auteri D, Barmaz S, Brancato A, Brocca D, Bura L, Carrasco Cabrera L, Chiusolo A, Civitella C, Court Marques D, Crivellente F, Ctverackova L, De Lentdecker C, Egsmose M, Fait G, Ferreira L, Greco L, Ippolito A, Istace F, Jarrah S, Kardassi D, Leuschner R, Lostia A, Lythgo C, Magrans JO, Medina P, Mineo D, Miron I, Nave S, Molnar T, Padovani L, Parra Morte JM, Pedersen R, Reich H, Sacchi A, Santos M, Serafimova R, Sharp R, Stanek A, Streissl F, Sturma J, Szentes C, Tarazona J, Terron A, Theobald A, Vagenende B, Van Dijk J, Villamar-Bouza L. Peer review of the pesticide risk assessment for the active substance bromoxynil in light of negligible exposure data submitted. EFSA J. 2018 Dec 13;16(12):e05490. doi: 10.2903/j.efsa.2018.5490. 4: Chen XX, Li WM, Wu Q, Zhi YN, Han LJ. Bromoxynil residues and dissipation rates in maize crops and soil. Ecotoxicol Environ Saf. 2011 Sep;74(6):1659-63. doi: 10.1016/j.ecoenv.2011.05.015. Epub 2011 Jun 15. 56(9):861-863. doi: 10.1080/15563650.2018.1433299. Epub 2018 Jan 30. 154(2):155-68. doi: 10.1016/j.envpol.2007.09.020. Epub 2007 Nov 7. 67(17):1321-52. doi: 10.1080/15287390490471424. 62(2):329-36. doi: 10.1021/jf404209d. Epub 2013 Dec 27. 104(6):1605-16. doi: 10.1111/j.1365-2672.2007.03709.x. Epub 2008 Jan 23. 56(5):377-380. doi: 10.1080/15563650.2017.1385790. Epub 2017 Oct 9. 17(3):442-7. doi: 10.1016/0272-0590(91)90195-a. 242(Pt A):769-777. doi: 10.1016/j.envpol.2018.07.049. Epub 2018 Jul 17. 21(12):2008-12. doi: 10.1139/m75-288. 70(7):638-57. doi: 10.1080/15287390600974593. 121(2):227-33. doi: 10.1007/s10265-008-0147-y. Epub 2008 Feb 7.
合成参考文献
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