CAS: 1689-02-7; Pyrrolidine-1-Sulfonyl Chloride

相似化合物

1184477-87-9 1411774-27-0 1251345-08-0

上下游产品

pyrrolidine pyrrolidine hydr°ChlorideN-Phenyl-3-(pyrrolidine-1-sulfonylamino)-benzamide N-tosylpyrrolidine N-(phenoxysulfonyl)-pyrrolidine ethyl 3-{3-(pyridin-3-ylmethyl)-5-[2-(1-pyrrolidinylsulphonylamino)ethyl]phenyl}propanoate

四氢吡咯置于磺酰氯体系中,化学反应 5.0H,以20%的收率获得吡咯啉-1-磺酰氯
参考文献:顺式咪唑啉的磺酰胺衍生物作为有效的 P53-Mdm2/mdmx 蛋白-蛋白相互作用抑制剂
标题:顺式咪唑啉的磺酰胺衍生物作为有效的 P53-Mdm2/mdmx 蛋白-蛋白相互作用抑制剂
摘要:P53-Mdm2/mdmx 相互作用抑制剂代表了在表达野生型 P53 蛋白的肿瘤中进行靶向抗癌治疗的前瞻性药物.这种基于咪唑啉的 Mdm2 靶向抑制剂,Nutlins,含有卤素取代的苯环,可显着降低化合物在水中的溶解度.在苯环和咪唑啉氮中加入合适的亲水性取代基可以提高化合物的水溶性.在这项研究中,我们合成了新型亲水性顺-2,4,5-三(烷氧基苯基)咪唑啉,并研究了 N-磺酰基取代基与未取代的烷氧基化合物相比对蛋白质-蛋白质相互作用的影响.使用蛋白质印迹分析对 A549,Rko 和 Sh-Sy5Y 癌细胞系研究所得化合物的生物活性.
Doi:10.1007/s00044-021-02802-W

专利信息

专利号:WO-2010115869-A1
优先权日:2009-04-03
标 题 :Propofol phosphonyl derivatives, synthesis, and use in long acting formulations
发明人：GONNISSEN YVES RENE JOHANNA PAUL
权利人:SEPS PHARMA N V; GONNISSEN YVES RENE JOHANNA PAUL
摘要:This invention relates to compounds represented by the structural formula (I), and the salts and stereoisomers thereof, wherein: - L is a linker selected from the group consisting of -(CH 2 ) P -O-, a single bond, formula (IA), -(CH 2 ) 1-8 -O-X(O)-, and - p is an integer from 1 to 8, - each R 3 and each R 4 is independently selected from the group consisting of C 1-20 alkyl, C 3-12 alkyl, C 3-12 cycloalkyl-C 1-4 alkyl, saturated heterocyclyl and saturated heterocyclyl-C 1-4 alkyl, and - X and Y are each independently C or S(O), - Z is selected from the group consisting of O, S(O) and NR 5 , - W is selected from the group consisting of halogen, OH, S(O)H and O - M + wherein M + is a monovalent cation; and - R 5 is selected from the group consisting of hydrogen and C 1-10 alkyl. These compounds are useful pharmaceutical agents with improved oral bioavailability.

专利号:WO-2023275607-A1
优先权日:2021-07-02
标 题 :Synthesis of n,n-dialkyl, -dialkenyl, -dialkynl, and related cyclics, sulfamoyl fluoride compounds using hydrogen fluoride

专利号:US-6936600-B2
优先权日:1999-04-01
标题:Sorbitol dehrydrogenase inhibitors
发明人：CHU-MOYER MARGARET Y; MYLARI BANAVARA L; ZEMBROWSKI WILLIAM J
权利人:PFIZER
摘要:This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, n n nwherein R 1 , R 2 and R 3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.

专利号:WO-9700872-A1
优先权日:1995-06-23
标题 :1,3,8-triaza- and 3,8-diaza-1-oxaspiro(4,5)decane derivatives
发明人：BERGER JACOB; CARTER DAVID SCOTT; FLIPPIN LEE ALLEN; WEINHARDT KLAUS KURT
权利人:HOFFMANN LA ROCHE
摘要:Heterocyclic compounds of Formula (I) in which n is 2, 3, 4, 5 or 6; t is 1, 2, 3 or 4; u is 0 or 1 (provided that t is not 1 when u is 0); X is O or N(R4), in which R4 is hydro, (C¿1-4 )alkyl, or aryl; Y and Z are independently C(O), C(S) or CH2 (provided that Y and Z are not both CH2); R 1, R2, and R3¿ are as defined in the specification; and their pharmaceutically acceptable salts and N-oxides, formulations containing them, their uses as therapeutic agents, and their synthesis. The compounds of this invention are selective 5-HT¿2 C receptor antagonists.

专利号:US-5739336-A
优先权日:1995-06-23
标题:1,3,8-triaza- and 3,8-diaza-1-oxaspiro 4,5! decane derivatives
发明人：WEINHARDT KLAUS K; BERGER JACOB; CARTER DAVID S; FLIPPIN LEE A
权利人:SYNTEX INC
摘要:Heterocyclic compounds of Formula I: I in which n is 2, 3, 4, 5 or 6; t is 1, 2, 3 or 4; u is 0 or 1 (provided that t is not 1 when u is 0); X is O or N(R4); Y and Z are independently C(O), C(S) or CH2 (provided that Y and Z are not both CH2); R1, R2, R3, and R4 are as defined in the specification; and their pharmaceutically acceptable salts and N-oxides, formulations containing them, their uses as therapeutic agents, and their synthesis.