CAS: 14883-87-5; Dl-3,4-Dihydroxymandelicacid

该化合物是一种手淫酚化合物,其特征是二氢氧基苯和氢氧乙酸的功能组,其立体特性(R)配置加强了生物化学和合成应用的选择性.Catechol(3,4-二氢氧基苯)和α-氢氧酸脂的存在有助于其抗氧化特性和金属皮质处理能力,使其在制药和催化研究中具有价值.该化合物的结构特征还表明,它作为精细化学合成的中间体或非对称催化的离子体具有潜在效用.其在极有机溶剂中的溶解性有利于实验室环境中的处理. 硬性分析方法,包括手性HPLC和NMR,确保研究应用的高纯度和一致性.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-9453037-B2
    优先权日:2011-07-28
    标 题 :Methylphenidate-prodrugs, processes of making and using the same
    发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
    权利人:KEMPHARM INC; KEMPHARM INC
    摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

    专利号:US-9012648-B2
    优先权日:2012-08-21
    标题 :Haptens of risperidone and paliperidone
    发明人：HASPESLAGH PIETER RIK; VLIEGEN MAARTEN; HRYHORENKO ERIC; DECORY THOMAS R; SANKARAN BANUMATHI
    权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
    摘要:The invention relates to compounds of Formula I, wherein R1 and R2 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from risperidone and paliperidone. The invention also relates to conjugates of a risperidone or paliperidone hapten and a protein.

    专利号:US-9303041-B2
    优先权日:2012-08-21
    标题 :Haptens of olanzapine
    发明人：DONAHUE MATTHEW GARRETT; GONG YONG; SALTER RHYS; HRYHORENKO ERIC; DECORY THOMAS R; REMMERIE BART; SANKARAN BANUMATHI
    权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
    摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzapine. The invention also relates to conjugates of an olanzapine hapten and a protein.

    专利号:US-9394354-B2
    优先权日:2012-08-21
    标题 :Haptens of paliperidone
    发明人：HASPESLAGH PIETER RIK; VLIEGEN MAARTEN; HRYHORENKO ERIC; DECORY THOMAS R; SANKARAN BANUMATHI
    权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
    摘要:The invention relates to compounds of Formula I, wherein L 1 , L 2 , and L 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from paliperidone. The invention also relates to conjugates of a paliperidone hapten and a protein.

    专利号:US-9304126-B2
    优先权日:2012-08-21
    标题:Haptens of quetiapine
    发明人：DONAHUE MATTHEW GARRETT; GONG YONG; SALTER RHYS; HRYHORENKO ERIC; DECORY THOMAS R; REMMERIE BART; SANKARAN BANUMATHI
    权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
    摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.

    专利号:US-12410437-B2
    优先权日:2016-07-12
    标 题:Incorporation of internal polya-encoded poly-lysine sequence tags and their variations for the tunable control of protein synthesis in bacterial and eukaryotic cells
    发明人：DJURANOVIC SERGEJ; GREEN RACHEL
    权利人:WASHINGTON UNIVERSITY ST LOUIS; UNIV JOHNS HOPKINS
    摘要:The present disclosure relates to modulation of protein expression.

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/bf02772200
    摘要:Bakale RP, Wald SA, Butler HT, Gao Y, Hong Y, Nie X, Zepp CM. Albuterol. A pharmaceutical chemistry review of R-, S-, and RS-albuterol. Clin Rev Allergy Immunol. 1996;14(1):7–35. doi: 10.1007/bf02772200.
    参考文献:10.1016/s0034-5288(96)90096-x
    摘要:Ley SJ, Waterman AE, Livingston A. Measurement of mechanical thresholds, plasma cortisol and catecholamines in control and lame cattle: A preliminary study. Research in Veterinary Science. 1996 Sep;61(2):172–3. doi: 10.1016/s0034-5288(96)90096-x.
    参考文献:10.1038/s41467-021-24482-1
    摘要:Wu P, Chen D, Ding W, Wu P, Hou H, Bai Y, Zhou Y, Li K, Xiang S, Liu P, Ju J, Guo E, Liu J, Yang B, Fan J, He L, Sun Z, Feng L, Wang J, Wu T, Wang H, Cheng J, Xing H, Meng Y, Li Y, Zhang Y, Luo H, Xie G, Lan X, Tao Y, Li J, Yuan H, Huang K, Sun W, Qian X, Li Z, Huang M, Ding P, Wang H, Qiu J, Wang F, Wang S, Zhu J, Ding X, Chai C, Liang L, Wang X, Luo L, Sun Y, Yang Y, Zhuang Z, Li T, Tian L, Zhang S, Zhu L, Chang A, Chen L, Wu Y, Ma X, Chen F, Ren Y, Xu X, Liu S, Wang J, Yang H, Wang L, Sun C, Ma D, Jin X, Chen G. The trans-omics landscape of COVID-19. Nature Communications. 2021 Jul 27;12(1):4543. doi: 10.1038/s41467-021-24482-1.
    参考文献:10.1016/s0021-9258(19)57475-0
    摘要:Majamaa K, Günzler V, Hanauske-Abel HM, Myllylä R, Kivirikko KI. Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase. Journal of Biological Chemistry. 1986 Jun;261(17):7819–23. doi: 10.1016/s0021-9258(19)57475-0.
    参考文献:10.1124/pr.56.3.1
    摘要:Eisenhofer G, Kopin IJ, Goldstein DS. Catecholamine metabolism: a contemporary view with implications for physiology and medicine. Pharmacol Rev. 2004 Sep;56(3):331–49. doi: 10.1124/pr.56.3.1.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知