CAS: 132-18-3; 4-(Benzhydryloxy)-1-Methylpiperidine Hydrochloride
- 英文名称4-(Benzhydryloxy)-1-Methylpiperidine Hydrochloride
- 中文名称4-二苯甲氧基-1-甲基哌啶 二苯拉林 盐酸盐
- IUPAC名称Piperidine, 4-(diphenylmethoxy)-1-methyl-, hydrochloride
- 其它别名Piperidine,4-(diphenylmethoxy)-1-methyl-, hydr°Chloride (6CI,8CI,9CI); 1-Methyl-4-piperidylbenzhydryl ether hydr°Chloride; 4-Diphenylmethoxy-1-methylpiperidinehydr°Chloride; Anginosan; Belfene; Dayfen; Diafen; Diafen (antihistamine); Diafen hydr°Chloride; Diaphen; Diphenpyraline hydr°Chloride; Diphenylpyralinehydr°Chloride; Diphenylpyraline te°Clate; Hispril; Hispril hydr°Chloride; Histryl; Histryl Spansule Capsules; Histyn; Kolton Jelly; Lergoban; Lergobine; Sumadil
- CAS编号132-18-3
- MFCD编号:MFCD00012835
- EINECS号:205-049-3
- FDA UNII编号:G9FU7F1E87
- 分子式:C19H24ClNO分子量:317.85
- 产品CID: 487944
- 同类组份化合物CAS147-20-6 (free base)132-18-3 (HCl)
- 产品分类有机原料 → 杂环化合物
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专利信息
专利号:WO-2025136243-A1
优先权日:2023-12-20
标题:Mechanochemical synthesis of histamine h1-receptor antagonists
发明人：AYDONAT SIMAY; OZEL MERTCAN; YIGITBASI JOANNA MARIANNA; BAYTEKIN BILGE; COLACINO EVELINA
权利人:IHSAN DOGRAMACI BILKENT UNIV; CENTRE NAT RECH SCIENT
摘要:The present invention relates to mechanochemical synthesis of histamine antagonists which are benzhydryl ethers and unsymmetrically disubstitutes piperazines and salts thereof. Said antihistamine active pharmaceutical ingredients can be diphenhydramine hydrochloride, cyclizine hydrochloride and diphenylpyraline hydrochloride. These antihistamines are used in the treatment of allergies, hives, hay fever (allergic rhinitis), conjunctivitis, reactions to insect bites and sings, nausea, motion sickness, insomnia.
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主要参考文献
1: Dinis-Oliveira RJ. Metabolomics of methadone: clinical and forensic toxicological implications and variability of dose response. Drug Metab Rev. 2016 Nov;48(4):568-576. Epub 2016 Jun 20. Review. doi: 10.1016/j.bmcl.2014.04.040. Epub 2014 Apr 18.
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合成参考文献
参考文献:10.1038/ncb3255
摘要:Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484–96.
摘要:
摘要:Gekkan Yakuji. Pharmaceuticals Monthly., 9(759), 1967
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摘要:Drugs in Japan, 6(333), 1982
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