CAS: 101079-67-8; 3-Chloro-2,6-Dinitropyridine
该化合物是分子式C5H3ClN44.的化学化合物,在2和6个位置上用两个硝基组替代的环,在3个位置上用氯原子替代的氯原子.该化合物的典型特征是黄色晶体外观,以其在合成各种有机化合物中的潜在用途而著称,特别是在农用化学品和制药领域.硝基化合物的存在有助于其反应,使其成为化学反应的有用中间体.此外,3-氯-2,6-硝基丙烯基丁具有诸如硝基化合物可能引发的爆炸等特性,可进行减少或替代反应.在处理该化合物时,安全防范至关重要,因为它可能因吸入或皮肤接触而造成健康风险.其稳定性和再活性可能因环境条件而不同而不同,因此必须妥善储存,以防止降解或意外反应.
物理性质
MSDS等安全信息
上下游产品
3-hydroxy-2,6-dinitropyridine 3-hydroxy-2-nitropyridine 5-chloro-2-pyridylamine 5-chloro-2-nitropyridine合成工艺路线路线简述
- 合成目标产物 2,6-Dinitro-3-Chloropyridine 主要起始原料 3-Hydroxy-2-Nitropyridine
- (文献来源)合成步骤主要原料 3-Hydroxy-2-Nitropyridine
📜3-羟基-2-硝基吡啶置于五氯化磷,硝酸,乙酸酐,溶剂黄146体系中,化学反应生成3-氯-2,6-二硝基吡啶
参考文献:Czuba; Plazek,Recueil Des Travaux Chimiques Des Pays-Bas,1958,Vol. 77,P. 92,95
标题:Czuba; Plazek,Recueil Des Travaux Chimiques Des Pays-Bas,1958,Vol. 77,P. 92,95
专利信息
专利号:US-6552239-B1
优先权日:1999-10-28
标题:Synthesis of cyclopropaneacetylene by a one-pot process
发明人：BRANDS KAREL M J
权利人:MERCK & CO INC
摘要:The present invention relates to a process for the preparation of cyclopropaneacetylene by reacting a ketophosphonate with a diazo-transfer reagent in the presence of non-nucleophilic base in an aprotic solvent to generate a reaction mixture containing a ketodiazophosphonate compound and then reacting the reaction mixture with cyclopropanecarboxaldehyde in a non-nucleophilic base and a protic solvent to yield cyclopropaneacetylene.
专利号:US-12202782-B2
优先权日:2020-11-19
标 题:Processes and intermediates for preparing MCL1 inhibitors
发明人：DIXON DARRYL D; ISCHAY MICHAEL A; JOHNSON TREVOR C; MERIT JEFFREY E; REGENS CHRISTOPHER S; STANDLEY ERIC A; STEINHUEBEL DIETRICH P
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.
专利号:GB-2355988-A
优先权日:1999-10-28
标 题:Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate
