CAS: 89793-12-4; Ethyl 2-Chloropyrimidine-5-Carboxylate

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CAS号95928-49-7 2-羟基嘧啶-5-羧酸乙酯 | CAS号763-69-9 3-乙氧基丙酸乙酯 | CAS号33458-27-4 2-氧-1,2,3,4-四氢嘧... | CAS号2223-96-3 6-氨基-2-硫氧代-1,2-... | CAS号2974-30-3 (Z)-2-(乙氧基甲基)-3... | CAS号34780-29-5 3-氧代丙酸乙酯 | CAS号879008-23-8 (Z)-ethyl 2-(et... | CAS号1086272-71-0 Ethyl (2E)-2-(e... | CAS号110099-99-5 2-氯嘧啶-5-甲酰氯 | CAS号57401-76-0 2-氨基嘧啶-5-甲酸乙酯 | CAS号1316214-52-4 Ricolinostat (A... | CAS号1753-50-0 2-氯-5-氰基嘧啶 | CAS号856595-94-3 2-氯-5-嘧啶酰胺 | CAS号875318-46-0 2-(4-羟甲基哌啶-1-基)... | CAS号603965-77-1 2-(哌嗪-1-基)嘧啶-5-羧酸乙酯

(Z)-Ethyl-2-(Ethoxymethyl)-3-Methoxyacrylate置于盐酸,溴,溶剂黄146,N,N-二甲基苯胺,三氯氧磷体系中,用 乙醇 作为反应溶剂,化学反应 3.0H,反应生成 2-氯嘧啶-5-羧酸乙酯
参考文献: Cdk Inhibitors Containing A Zinc Binding Moiety[fr] Inhibiteurs Des Kinases Dépendantes Des Cyclines (Cdk) Contenant Une Fraction De Liaison Au Zinc
标题: Cdk Inhibitors Containing A Zinc Binding Moiety[fr] Inhibiteurs Des Kinases Dépendantes Des Cyclines (Cdk) Contenant Une Fraction De Liaison Au Zinc
摘要:本发明涉及cdk抑制剂及其在治疗癌症等细胞增殖性疾病中的应用.该发明的化合物还可能作为hdac抑制剂.

专利信息

专利号:US-11666569-B2
优先权日:2013-10-24
标题 :Treatment of polycystic diseases with an HDAC6 inhibitor
发明人：GRADILONE SERGIO A; LARUSSO NICHOLAS F
权利人:MAYO FOUND MEDICAL EDUCATION & RES; NAT INSTITUTES OF HEALTH NIH U S DEPT OF HEALTH AND HUMAN SERVICES DHHS U S GOVERNMENT
摘要:An HDAC6-specific inhibitor (i.e., a compound of Formula I or II) is shown to reduce the pathogenesis associated with polycystic disease. Administration of an HDAC6-specific inhibitor attenuated many of the symptoms characteristic of polycystic liver disease including cyst formation, cyst growth and cholangiocyte proliferation. Treatment with a HDAC6-specific inhibitor also increased the amount of bile duct acetylated tubulin and β-catenin phosphorylation and/or acetylation while reducing bile duct β-catenin synthesis. These results demonstrate that HDAC6 is overexpressed in cystic cholangiocytes and that its pharmacological inhibition reduces cholangiocyte proliferation and cyst growth.

专利号:US-10144714-B2
优先权日:2015-06-08
标 题 :Methods of making protein deacetylase inhibitors
发明人：SEYEDI FARZANEH; VAN DUZER JOHN H
权利人:ACETYLON PHARMACEUTICALS INC
摘要:The present invention relates to methods and intermediates useful for the synthesis of protein deacetylase inhibitors.

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2011152295-A1
优先权日:2008-09-08
标 题:Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
权利人:LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:CN-103664796-A
优先权日:2013-12-06
标 题 :Synthesis of 5-[2-(5-carboxy-pyrimidinyl)]-1,3-benzenedicarboxylic acid

专利号:US-2024383908-A1
优先权日:2021-07-07
标 题 :Synthesis and application of phosphatase degrader