CAS: 887921-99-5; (S)-6,7-Dihydro-5H-Cyclopenta[b]Pyridin-7-Ol

英文名称(S)-6,7-Dihydro-5H-Cyclopenta[b]Pyridin-7-Ol
中文名称(S)-6,7-二氢-5H-环戊二烯并[b]吡啶-7-醇
IUPAC名称(S)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol
其它别名(7S)-6,7-二氢-5H-7-羟基 -环戊[b]并吡啶; (7S)-6,7-Dihydro-5H-Cyclopenta[b]Pyridin-7-Ol
CAS编号887921-99-5
MFCD编号:MFCD11558942
分子式:C8H9NO分子量:135.17
产品CID: 1908258
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: XLPDFBUFTAWCIB-ZETCQYMHSA-N
InChI=1S/C8H9NO/c10-7-4-3-6-2-1-5-9-8(6)7/h1-2,5,7,10H,3-4H2/t7-/m0/s1
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数*

相似化合物

912277-45-3 41598-71-4 31170-78-2

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H315-H319
防范说明P264-P280-P302+P352-P362+P364

上下游产品

6,7-二氢-5H-环戊并[b]吡啶-7-醇 6,7-Dihydro-5H-Cyclopenta[b]Pyridin-7-Ol 41598-71-4
6,7-二氢-5H-环戊并[b]吡啶-7-基乙酸酯 6,7-Dihydro-5H-Cyclopenta[b]Pyridin-7-Yl Acetate 90685-59-9
2,3-环戊烯并吡啶 2,3-Cyclopentenopyridine 533-37-9
6,7-二氢-5H-环戊并[b]吡啶1-氧化物 6,7-Dihydro-5H-Cyclopenta[b]Pyridine 1-Oxide 90685-58-8
5,6-二氢-7H-环戊并[b]吡啶-7-酮 5H,6H,7H-Cyclopenta[b]Pyridin-7-One 31170-78-2

合成工艺路线路线简述

41598-71-4 + 98-88-4 = 887921-99-5 + 887922-00-1
反应条件:1.1 Catalysts: Cupric Chloride,Borate(1-),Bis[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]Diethyl-,Hydrogen ... Solvents: Dichloromethane; 2 - 3 H,Rt1.2 Rt1.3 Reagents: Diisopropylethylamine; 2 H,0 °C
标题:Kinetic Resolution Of Diols And Pyridyl Alcohols By Cu(Ii)(Borabox)-Catalyzed Acylation
作者:Mazet,Clement; Roseblade,Stephen; Koehler,Valentin; Pfaltz,Andreas
参考文献:Organic Letters 日期:2006 卷标:8(9) 页码:1879-1882]

90685-58-8 = 887921-99-5 + 912277-45-3
反应条件:1.1 Reagents: Trifluoroacetic Anhydride Solvents: Dichloromethane; Rt -> 0 °C; 0 °C -> Rt; 4 H,Rt1.2 Reagents: Lithium Hydroxide Solvents: Dichloromethane,Water; 3 H,Rt
标题:Iridium Catalysts With Bicyclic Pyridine-Phosphinite Ligands: Asymmetric Hydrogenation Of Olefins And Furan Derivatives
作者:Saiser,Stefan; Et Al
参考文献:Angewandte Chemie 日期:2006 卷标:45(31) 页码:5194-5197]

533-37-9 = 887921-99-5 + 912277-45-3
反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Methyltrioxorhenium Solvents: Dichloromethane,Water; Rt -> 0 °C; 19 H,Rt1.2 Reagents: Manganese Oxide (Mno2); Rt2.1 Reagents: Trifluoroacetic Anhydride Solvents: Dichloromethane; Rt -> 0 °C; 0 °C -> Rt; 4 H,Rt2.2 Reagents: Lithium Hydroxide Solvents: Dichloromethane,Water; 3 H,Rt
标题:Iridium Catalysts With Bicyclic Pyridine-Phosphinite Ligands: Asymmetric Hydrogenation Of Olefins And Furan Derivatives
作者:Saiser,Stefan; Et Al
参考文献:Angewandte Chemie 日期:2006 卷标:45(31) 页码:5194-5197]

= 887921-99-5
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Ethanol; 2 H,Rt
标题:Enantiopure Synthesis Of 7-(1-Pyrindanyl)Propargyl Ethers As Rasagiline Analogues Via Chemical Or Enzymatic Resolution Of 1-Pyrindan-7-Ol
作者:Sousa,Carlos A. D.; Sampaio-Dias,Ivo E.; Rizzo-Aguiar,Fabio; Garcia-Mera,Xerardo; Rodriguez-Borges,Jose E.
参考文献:Rsc Advances 日期:2015 卷标:5(126) 页码:104509-104515]

= 887921-99-5
反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 70 °C
标题:Reaction Of 2-Alkyl Pyridine N-Oxide Derivatives With Mosher'S Acyl Chloride: First Example Of Stereoselective Boekelheide Rearrangement
作者:Andreotti,Daniele; Miserazzi,Emanuele; Nalin,Arnaldo; Pozzan,Alfonso; Profeta,Roberto; Et Al
参考文献:Tetrahedron Letters 日期:2010 卷标:51(50) 页码:6526-6530]

41598-71-4 + 98-88-4 = 887921-99-5 + 887922-00-1
反应条件:1.1 Catalysts: Copper Chloride,Borate(1-),Bis[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]Diethyl-,Hydrogen ... Solvents: Dichloromethane; 90 Min,Rt1.2 Rt -> 0 °C1.3 Reagents: Diisopropylethylamine; Overnight,0 °C -> Rt
标题:Kinetic Resolution Of Pyridyl Alcohols By Cu(Ii)(Borabox)-Catalyzed Acylation
作者:Roseblade,Stephen J.; Pfaltz,Andreas
参考文献:Synthesis 日期:2007 卷标:(23) 页码:3751-3753

📜6,7-二氢-5H-环戊并[b]吡啶-7-醇置于4-二甲氨基吡啶,N,N'-二环己基碳二亚胺,Potassium Hydroxide体系中,用乙醇,二氯甲烷作为反应溶剂,化学反应 6.0H,反应生成 (7S)-6,7-二氢-5H-环戊并[b]吡啶-7-醇
参考文献:Enantiopure Synthesis Of 7-(1-Pyrindanyl)Propargyl Ethers As Rasagiline Analogues Via Chemical Or Enzymatic Resolution Of 1-Pyrindan-7-Ol
标题:Enantiopure Synthesis Of 7-(1-Pyrindanyl)Propargyl Ethers As Rasagiline Analogues Via Chemical Or Enzymatic Resolution Of 1-Pyrindan-7-Ol
摘要:通过化学和/或酶解的手段,有效地制备了对映纯的7-(1-吡啶基)丙炔基醚-与拉沙吉林类似物-通过手性前体1-吡啶基-7-醇的分离得到.
DOI:10.1039/c5Ra24868J