CAS: 878207-82-0; 2,3-Dibromo-5-Fluoropyridine

相似化合物

156772-60-0 1256805-06-7 660425-16-1

上下游产品

3-bromo-5-fluoropyridin-2-amine 2-amino-5-fluoropyridine 3-bromo-5-fluoropyridine-2- carbonitrile

2-氨基-3-溴-5-氟吡啶置于氢溴酸,溴,Sodium Nitrite体系中,用50%的收率获得产物2,3-二溴-5-氟吡啶
参考文献: Nitrogen Heterocyclic Compounds Useful As Pde10 Inhibitors[fr] Composés Azotés Hétérocycliques Convenant Comme Inhibiteurs De La Pde10
标题: Nitrogen Heterocyclic Compounds Useful As Pde10 Inhibitors[fr] Composés Azotés Hétérocycliques Convenant Comme Inhibiteurs De La Pde10
摘要:式(I)的不饱和氮杂环化合物:(I),如规范中定义的,含有它们的组合物,以及制备这种化合物的方法.本文还提供了通过抑制pde10治疗可治疗的疾病或疾病的方法,如肥胖症,亨廷顿病,非胰岛素依赖型糖尿病,精神分裂症,躁郁症,强迫症等.

专利信息

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.