CAS: 81740-18-3; 1-N-Boc-3-Fluoroaniline

该化合物是一种有机化合物,其特点是氨基甲酸酯功能组,该物质具有与氮原子相连的异丁基(1,1-二甲基乙基)组,该物质与3-氟苯基组有进一步的联系;苯基环上存在氟基原子,会影响化合物的反活性和生物活动,有可能加强其脂性并改变其与生物目标的相互作用;氨基甲酸酯结构表明,该物质可能具有氨基甲酯的典型特性,例如可能用作农药或除草剂,以及可能用于药用化学.该化合物的稳定性,溶性以及再活性可能因环境条件和其他化学品的存在而不同.安全数据和处理预防措施与许多有机化合物一样,对于减轻与接触或环境影响有关的任何风险至关重要.

结构式图片

物理性质

MSDS等安全信息

上下游产品

meta-fluoroaniline tert-butyl dicarbonatedi-tert-butyl dicarbonate 2-Oxo-2,3-dihydro-benzooxazole-7-carboxylic acid (4-chloro-phenyl)-amide 7-(Hydroxy-phenyl-methyl)-3H-benzooxazol-2-one 7-Phenylsulfanyl-3H-benzooxazol-2-one N-(tert-butoxycarbonyl)-3-fluoro-2-thiophenylaniline

合成工艺路线路线简述

  • 24424-99-5 = 81740-18-3
    反应条件:1.1 Solvents: Tetrahydrofuran; 12 H,Rt
    标题:Comparative Catalytic C-H Vs. C-Si Activation Of Arenes With Pd Complexes Directed By Urea Or Amide Groups
    作者:Rauf,Waqar; Thompson,Amber L.; Brown,John M.
    参考文献:Chemical Communications (Cambridge 日期:2009 卷标:(26) 页码:3874-3876]

    24424-99-5 = 81740-18-3
    反应条件:1.1 Solvents: Ethanol
    标题:Ligand-Promoted Meta-C-H Amination And Alkynylation
    作者:Wang,Peng; Li,Gen-Cheng; Jain,Pankaj; Farmer,Marcus E.; He,Jian; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2016 卷标:138(42) 页码:14092-14099]

    24424-99-5 = 81740-18-3 [标题:Reaction Conditions
    标题:Preparation And Electrophilic Trapping Of 7-Lithiated Benzoxazoles Generated Via Benzyne Cyclization
    作者:Clark,Robin D.; Caroon,Joan M.
    参考文献:Journal Of Organic Chemistry 日期:1982 卷标:47(14) 页码:2804-6]

    4248-19-5 = 81740-18-3 + 60144-53-8
    反应条件:1.1 Catalysts: 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone,Tetraethylammonium Tetrafluoroborate Solvents: Acetonitrile; Rt
    标题:Organocatalyzed Photoelectrochemical C-H Amination Of Arenes
    作者:Hou,Zhong-Wei; Yan,Hong; Song,Jinshuai; Xu,Hai-Chao
    参考文献:Chemrxiv 日期:2021 卷标:1 页码:1-4]

    = 81740-18-3
    反应条件:1.1 Reagents: Lithium Tetrafluoroborate Solvents: Ethyl Acetate,Hexafluorobenzene; 2 H,90 °C
    标题:Libf4-Promoted Aromatic Fluorodetriazenation Under Mild Conditions
    作者:Zhang,Hongjin; Wu,Jianbo; Zhang,Xingxian; Fan,Mengyang
    参考文献:Journal Of Organic Chemistry 日期:2023 卷标:88(17) 页码:12826-12834]

    6627-89-0 = 81740-18-3
    反应条件:1.1 Reagents: Tert-Butyllithium Solvents: Pentane,Tetrahydrofuran; 45 Min,-78 °C1.2 Solvents: Tetrahydrofuran; 12 H,-78 °C -> Rt1.3 Reagents: Ammonium Chloride Solvents: Water
    标题:Formation Of Hindered Arylcarbamates Using Alkyl Aryl Carbonates Under Highly Reactive Conditions
    作者:Shahsavari,Shahien; Gooding,James; Wigstrom,Travis; Fang,Shiyue
    参考文献:Chemistryselect 日期:2017 卷标:2(13) 页码:3959-3963]

    24424-99-5 = 81740-18-3
    反应条件:1.1 Solvents: Tetrahydrofuran; 10 Min,25 °C; 4 - 24 H,25 °C
    标题:Highly Ortho-Selective Chlorination Of Anilines Using A Secondary Ammonium Salt Organocatalyst
    作者:Xiong,Xiaodong; Yeung,Ying-Yeung
    参考文献:Angewandte Chemie 日期:2016 卷标:55(52) 页码:16101-16105]

    24424-99-5 = 81740-18-3
    反应条件:1.1 Solvents: Ethanol; Rt
    标题:Ligand-Promoted Meta-C-H Arylation Of Anilines,Phenols,And Heterocycles
    作者:Wang,Peng; Farmer,Marcus E.; Huo,Xing; Jain,Pankaj; Shen,Peng-Xiang; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2016 卷标:138(29) 页码:9269-9276]

    4248-19-5 = 81740-18-3 + 60144-53-8
    反应条件:1.1 Reagents: Tetraethylammonium Tetrafluoroborate Catalysts: 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone Solvents: Acetonitrile; Rt
    标题:Photoelectrocatalytic C-H Amination Of Arenes
    作者:Hou,Zhong-Wei; Yan,Hong; Song,Jinshuai; Xu,Hai-Chao
    参考文献:Green Chemistry 日期:2023 卷标:25(20) 页码:7959-7962
📜Tert-Butyl (E)-(3-(3,3-Dimethyltriaz-1-En-1-yl)Phenyl)Carbamate置于lithium Tetrafluoroborate体系中,用 六氟苯,乙酸乙酯 作为反应溶剂,以87 %的收率获得产物1-N-Boc-3-氟苯胺
参考文献:Libf4 促进温和条件下芳香族氟代三嗪化反应
标题:Libf4 促进温和条件下芳香族氟代三嗪化反应
摘要:开发了一种通过libf 4促进的3,3-二甲基-1-芳基三氮烯的芳香族氟代三氮烯化反应高效且温和的氟化方法.在不存在质子酸或强路易斯酸的情况下,反应顺利进行并倾向于在2小时内完成.该方法可耐受多种官能团,并以中等至优异的收率提供芳基氟化物产物.
DOI:10.1021/acs.Joc.3C01239

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主要参考文献

参考标题:Generation Of Oxazolidine-2,4-Diones Bearing Sulfur-Substituted Quaternary Carbon Atoms By Oxothiolation/cyclization Of Ynamides
作者:Hai Huang,Junzhen Fan,Guangke He,Zhimin Yang,Xiaodong Jin,Qi Liu,Hongjun Zhu |发布日期:2016.2.12
摘要:A Novel Method For Metal‐free Oxothiolation Of Ynamides To Construct Oxazolidine‐2,4‐diones Bearing Sulfur‐substituted Quaternary Carbon Atoms Has Been Developed. It Represents A Rare C−o Bond Cleavage Of Ynamides, As Well As A Facile And Tandem Approach For The Formation Of C−o, C−s, And C−cl Bonds. This Redox‐neutral Protocol Can Be Applied To The Synthesis Of Multisubstituted Oxazolidine‐2,4‐diones
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