CAS: 811842-25-8; (S)-2-Amino-2-(Tetrahydro-2H-Pyran-4-yl)Acetic Acid

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53284-84-7 475649-32-2 711017-85-5

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tetrahydro-2H-pyran-4-carboxylic acid 2-oxo-2-(tetrahydro-2H-pyran-4-yl)acetic acid(S)-methoxycarbonylamino(tetrahydropyran-4-yl)acetic acid [(S)-2-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidin-1-yl}-2-oxo-1-(tetrahydropyran-4-yl)-ethyl]-carbamic acid methyl ester [(S)-2-((2S,4S)-4-methyl-2-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-pyran-4-yl)-ethyl]-carbamic acid methyl ester

📜2-Oxo-2-(Tetrahydro-2H-Pyran-4-yl)Acetic Acid置于formate Dehydrogenase,Leucine Dehydrogenase,氨,甲酸铵,Sodium Methylate,Nicotinamide Adenine Dinucleotide体系中,用 水,异丙醇 作为反应溶剂,化学反应 0.08H,反应生成 L-4'-四氢吡喃基甘氨酸
参考文献:Synthesis Method For L-Cyclic Alkyl Amino Acid And Pharmaceutical Composition Having Thereof
标题:Synthesis Method For L-Cyclic Alkyl Amino Acid And Pharmaceutical Composition Having Thereof
摘要:本公开提供了一种l-环烷基氨基酸的合成方法和含有该氨基酸的药物组合物.该合成方法包括:步骤a.) 准备具有结构式(i)或结构式(II)的环烷基酮酸或环烷基酮酸盐,步骤b.) 将环烷基酮酸或环烷基酮酸盐与甲酸铵,亮氨酸脱氢酶,甲酸脱氢酶和辅酶nad+混合,并进行还原胺化反应以反应生成l-环烷基氨基酸,其中结构式(i)为n1≧1,M1≧0,M1为h或一价阳离子;结构式(II)为n2≧0,M2≧0,M2为h或一价阳离子,亮氨酸脱氢酶的氨基酸序列为序列号1.

专利信息

专利号:US-2016319312-A1
优先权日:2013-07-29
标 题 :Synthesis method for l-cyclic alkyl amino acid and pharmaceutical composition having thereof
发明人：HONG HAO; ZHENG CHANGSHENG; GUO LINA
权利人:ASYMCHEM LABORATORIES (TIANJIN) CO LTD; ASYMCHEM LIFE SCIENCE (TIANJIN) CO LTD; TIANJIN ASYMCHEM PHARMACEUTICAL CO LTD; ASYMCHEM LABORATORIES (FUXIN) CO LTD; JILIN ASYMCHEM LABORATORIES CO LTD
摘要:A synthesis method for L-cyclic alkyl amino acid and a pharmaceutical composition having the said amino acid are provide in the present disclosure provides. The synthesis method comprises: step A.) preparing a cyclic alkyl keto acid or a cyclic alkyl keto acid salt having Structural Formula (I) or Structural Formula (II), and step B.) mixing the cyclic alkyl keto acid or the cyclic alkyl keto acid salt with ammonium formate, a leucine dehydrogenase, a formate dehydrogenase and a coenzyme NAD + , and carrying out a reductive amination reaction to generate the L-cyclic alkyl amino acid, wherein the Structural Formula (I) is n n n n n n n n n n where n 1 ≧1, m 1 ≧0 and the M 1 is H or a monovalent cation; the Structural Formula (II) is n n n n n n n n n n where n 2 ≧0, m 2 ≧0, the M 2 is H or a monovalent cation, an amino acid sequence of the leucine dehydrogenase is SEQ ID No.1.