CAS: 55332-38-2; (S)-2-(4-Chlorophenyl)-3-Methylbutanoic Acid

上下游产品

CAS号66230-04-4 顺式氰戊菊酯

📜对氯苯乙酸置于bis(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate,(R)-(S)-Diphosphine 硫酸,氢气,异丙基氯化镁体系中,用 四氢呋喃,甲醇 作为反应溶剂,20.0~40.0 °C,5.0 Mpa 条件下,反应 22.75H,反应生成 (S)-2-(4-氯苯基)-3-甲基丁酸
参考文献:实用合成(S)-2-(4-氟苯基)-3-甲基丁酸(钙拮抗剂米贝拉地尔的关键组成部分)
标题:实用合成(S)-2-(4-氟苯基)-3-甲基丁酸(钙拮抗剂米贝拉地尔的关键组成部分)
摘要:开发了一种短的,技术上可行的路线来合成(S)2-(4-氟苯基)-3-甲基丁酸(S)-2,从4-氟苯基乙酸开始,总产率为80%.在含有手性阻转异构体二膦的钌(II)羧基络合物存在下,易获得的不饱和酸3的不对称氢化提供了高达94%ee的(S)-2 .通过结晶其钠盐,将(S)-2的ee提高至98%.相同的方案也适用于(S)-2-(4-氯苯基)-3-甲基丁酸的合成.
DOI:10.1016/s0957-4166(97)00498-9

专利信息

专利号:US-4546198-A
优先权日:1983-01-18
标 题 :Asymmetric synthesis of esters and acids
发明人：STOUTAMIRE DONALD W
权利人:SHELL OIL CO
摘要:Stereoisomerically-enriched esters are prepared by treating a non-symmetrical ketene with a racemic or chiral tertiary-base-substituted alkylcarbinol. Optional hydrolysis of the esters gives the corresponding optically-active carboxylic acids corresponding to the non-symmetrical ketene.

专利号:US-5925676-A
优先权日:1996-09-13
标题 :Ester compounds pesticidal compositions containing the same and itermediates for synthesis thereof
发明人：IWASAKI TOMONORI; TSUSHIMA KAZUNORI; SUGANO MASAYO
权利人:SUMITOMO CHEMICAL CO
摘要:An ester compound represented by the formula ##STR1## wherein R 1 and R 2 may be the same or different and each represent a C 1 -C 6 alkyl group, or other specified groups, which may be optionally substituted with one or more halogen atoms; and R 3 represents a pyrethroid acid residue (a group resulting from elimination of the carboxyl group from pyrethroid acid), and a pesticidal composition containing the ester compound as an active ingredient.