CAS: 529-38-4; Cocaethylene

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苯甲醯艾克寧 Benzylecgonine 519-09-5

📜乙醇,苯甲醯艾克寧置于草酰氯体系中,化学反应 12.33H,以60%的收率获得产物可卡乙碱
参考文献:Cocaethylene,The In Vivo Product Of Cocaine And Ethanol,Is A Narcotic More Potent Than Its Precursors
标题:Cocaethylene,The In Vivo Product Of Cocaine And Ethanol,Is A Narcotic More Potent Than Its Precursors
摘要:首次测定了古柯乙烯[系统标题:(1R,2R,3S,5S)-3-苯甲酰氧基-8-甲基-8-氮杂双环[3.2.1]辛烷-2-羧酸乙酯](c18H23No4)的分子构象和超分子结构.可卡乙烯是可卡因和乙醇同时服用时在体内产生的一种麻醉剂.古柯乙烯的分子内和分子间特征与其效力较弱的麻醉剂前体可卡因非常相似.唯一的分子差异在于乙氧羰基甲基的构象.与可卡因相似,古柯乙烯中的羧基原子和 α-C 原子是共面的,但在本文报告的麻醉剂中,乙基的甲基 C 原子弯曲了约 90°,偏离了这一平面.主要的超分子图案是一条由弱 C-H...O 接触稳定的一维链.
DOI:10.1107/s2053229617012852

专利信息

专利号:US-5663345-A
优先权日:1992-12-31
标 题:Derivatives of benzoylecgonine, ecgonine and ecgonidine and methods for preparing and using same
发明人：SOMERS LOWELL M; WYNN JAMES E
权利人:ENTROPIN INC
摘要:The present invention relates to a novel class of benzoylecgonine, ecgonine and ecgonidine derivatives which are useful for preventing and treating immunoregulatory disorders, neuromuscular. disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. The compounds of this invention are conveniently obtained by chemical synthesis. Accordingly, this invention also relates to methods for preparing the benzoylecgonine, ecgonine and ecgonidine derivatives and to pharmaceutical compositions containing these derivatives.

专利号:US-7993390-B2
优先权日:2002-02-08
标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
权利人:BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.