CAS: 52-78-8; (8R,9S,10R,13S,14S,17S)-17-Ethyl-17-Hydroxy-13-Methyl-1,2,6,7,8,9,10,11,12,14,15,16-Dodecahydrocyclopenta[a]Phenanthren-3-One

上下游产品

CAS号68-22-4 炔诺酮 | CAS号1042-57-5 3-methoxy-19-no... | CAS号734-32-7 甲基双酮 | CAS号6961-15-5 (3α,5α,17α)-19-...

📜炔诺酮置于palladium 10% On Activated Carbon,氢气体系中,用 甲醇 作为反应溶剂,化学反应 6.0H,反应生成 乙诺酮
参考文献: Compounds For Targeted Therapies Of Castration Resistant Prostate Cancer[fr] Composés Pour Thérapies Ciblées Du Cancer De La Prostate Résistant à La Castration
标题: Compounds For Targeted Therapies Of Castration Resistant Prostate Cancer[fr] Composés Pour Thérapies Ciblées Du Cancer De La Prostate Résistant à La Castration
摘要:本发明一般涉及用于治疗的新化合物.具体而言,本公开涉及对治疗癌症,特别是去势抵抗性前列腺癌的有用的新四环化合物.本公开范围内涉及药物组合物和通过单独或与其他治疗方法联合给予这种化合物的治疗癌症患者的方法.

专利信息

专利号:US-3959322-A
优先权日:1960-09-22
标 题:Synthesis of 13-alkyl-gon-4-ones
发明人：HUGHES GORDON ALAN; SMITH HERCHEL
权利人:SMITH HERCHEL
摘要:The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.

专利号:US-2025281509-A1
优先权日:2021-04-26
标 题 :Sequential hormone therapy to improve survival and enhance response to immune therapy in men with prostate cancer
发明人：DENMEADE SAMUEL R; ISAACS JOHN T; ANTONARAKIS EMMANUEL S; KACHHAP SUSHANT; MARKOWSKI MARK CHRISTOPHER
权利人:UNIV JOHNS HOPKINS
摘要:Disclosed are methods for treating men with castrate resistant prostate cancer with a sufficient dose of testosterone to achieve supraphysiologic serum levels of testosterone in sequence with androgen ablative treatment or androgen synthesis inhibitors for one or more cycles until evidence of radiographic progression, at which point the subject will receive immune checkpoint blockade therapy.