CAS: 501692-44-0; (S)-2-((R)-2-(2-((3,3-Dibutyl-7-(Methylthio)-1,1-Dioxido-5-Phenyl-2,3,4,5-Tetrahydrobenzo[f][1,2,5]Thiadiazepin-8-yl)Oxy)Acetamido)-2-(4-Hydroxyphenyl)Acetamido)Butanoic Acid

专利信息

专利号:US-12240808-B2
优先权日:2021-05-28
标 题 :Process for the synthesis of calebin-a and its intermediates
发明人：MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; NAIDU PENTAKOTA PARADESI
权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; NAIDU PENTAKOTA PARADESI
摘要:The invention discloses novel intermediates in the synthesis of Calebin A represented by formula 3. The invention also covers processes for the synthesis of Calebin-A and its analogs using compounds of formula 3.

专利号:US-10392361-B2
优先权日:2016-01-21
标题:Process for the synthesis of intermediates of Nebivolol
发明人：BARTOLI SANDRA; MANNUCCI SERENA; GRISELLI ALESSIO; STEFANINI ALESSIO
权利人:MENARINI INT OPERATIONS LUXEMBOURG SA
摘要:The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl)chromans of formula I. n The intermediates thus obtained can be used for the synthesis of Nebivolol.

专利号:US-11401273-B2
优先权日:2018-11-20
标题:Asymmetric synthesis of Azaspiro compounds
发明人：LELETI RAJENDER REDDY; WAMAN YOGESH; KALLURE PRIYA; BEGUM ZUBEDA; DIVYA THUMBAN; NALIVELA KUMARA SWAMY; VIJAY SAURABH; PARIKH PARANJAY; KOTTURI SHARADSRIKAR; PATEL CHIRAG; NAYAK KRISHNA; BAHAROONI KASIMRAZA; ZALAVADIYA VINKAL
权利人:PIRAMAL PHARMA LTD
摘要:The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.

专利号:US-10647655-B2
优先权日:2016-09-02
标题:Method for the synthesis of permethrin
发明人：PULLAGURLA MANIK REDDY; NANDA KUMAR MECHERIL VALSAN; VELIGETLA MADHUSUDHANA RAO; RANGISETTY JAGADEESH BABU
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:An improved method for the synthesis of substantially pure Permethrin having purity greater than 99.5% by Gas Chromatography provided. The embodiments also relates to a purification process of Permethrin by recrystallization from methanol-water mixture.

专利号:US-6027708-A
优先权日:1998-09-08
标 题:Process for the synthesis of flyash based zeolite-Y
发明人：RAYALU SADHANA; LABHASETWAR NITIN KUMAR; KHANNA PURUSHOTTAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a process for the synthesis of flyash based zeolite-Y (FAZ-Y), comprising grainding and mixing of flyash with caustic soda in a ratio ranging between 1:0.4-1:1.2 to obtain a fine homogenous fusion mixture, heating the said fusion mixture in an invert vessel at about 500-600° C. for about 1-2 hours to obtain a fused mass, cooling, milling, and mixing of the said fused mass in distilled water for about 8-12 hours, subjecting the said slurry to hydrothermal crystallization at about 90-110° C. for 8 to 12 hours to obtain FAZ-Y crystals, washing the said crystals with water and then subjecting the washed crystals to oven drying at 50-60° C. to obtain the desired FAZ-Y crystals.

专利号:US-9611255-B2
优先权日:2015-06-10
标题 :Process for total synthesis of flavonoid compounds and isomers thereof
发明人：RAO BATCHU VENKATESWARA; LINGAMURTHY MACHA; RAJU Gurrapu; SARMA VANKA UMAMAHESWARA
权利人:COUNCIL SCIENT IND RES; COUNCIL SCIENT IND RES
摘要:The present invention relates to the a process for total synthesis of flavonoid compounds of general formula I and isomers thereof n nwherein R 1 and R 2 is OH; R 3 â•?H orn n n n n n n n n n n The present invention particularly relates to the process for preparation and separation of (2S,3S)-taxifolin-6-C-β-D-glucopyranoside (ulmoside A), (2R,3R)-taxifolin-6-C-β-D-glucopyranoside and taxifolin.