CAS: 38870-89-2; Methoxyacetyl Chloride

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21062-20-4 16024-55-8 13831-31-7

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CAS号625-45-6 甲氧基乙酸 | CAS号107-30-2 氯甲基甲醚 | CAS号201230-82-2 carbon monoxide | CAS号98-88-4 苯甲酰氯 | CAS号36755-02-9 3-氯甲基-4-甲氧基苯甲酸甲酯 | CAS号3938-96-3 甲氧基乙酸乙酯 | CAS号17965-59-2 3-bromo-2-[(3-b... | CAS号65338-71-8 5-tert-butyl-2-... | CAS号19387-83-8 4-叔丁基-2,6-二甲基苄基氯 | CAS号25028-52-8 Phosphonic acid... | CAS号19692-45-6 4-叔丁基苄氯 | CAS号29417-89-8 (Z)-1-METHOXY-3... | CAS号102-04-5 二苄基甲酮 | CAS号52577-09-0 3-(氯甲基)-4-甲氧基苯甲醛

甲氧基乙酸置于氯化亚砜体系中,化学反应 1.0H,以69%的收率获得甲氧基乙酰氯
参考文献:来自氨基多元醇和α-二羰基的多环化合物:结构和在异位配体合成中的应用.
标题:来自氨基多元醇和α-二羰基的多环化合物:结构和在异位配体合成中的应用.
摘要:乙二醛和三(羟甲基)氨基甲烷的结晶2:2缩合产物("乙二胺")的结构和立体化学最终通过x射线衍射分析确定.杂原子的单数排列表明,使用谷胱甘肽作为合成金属离子的二位配体的起始材料.制备了一些谷胱甘肽衍生物,并通过esi-Ms和NMR初步研究了它们与碱金属离子的结合性能.
Doi:10.1039/b500580A

专利信息

专利号:US-10308588-B2
优先权日:2014-12-15
标 题 :Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis
发明人：CÓRDOVA ARMANDO; PALO-NIETO CARLOS; AFEWERKI SAMSON
权利人:ORGANOFUEL SWEDEN AB
摘要:A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-5204456-A
优先权日:1986-04-08
标题:Derivatives of nucleosides and their use for the synthesis of oligonucleotides
发明人：MOLKO DIDIER; SCHULHOF JEAN-CLAUDE; TEOULE ROBERT
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:The invention relates to derivatives of nucleosides and their use for the synthesis of oligonucleotides. These derivatives are in accordance with the formula: (I) in which B represents a radical derived from guanine, cytosine or adenine, whose exocylic NH group is protected by the group with R1 representing a hydrogen atom or a alkyl radical and R2 a hydrogen atom, and alkyl radical, an alkoxy radical and optionally substituted aryloxy radical, R3 represents a hydrogen atom, the dimethoxytrityl radical or the radical R4 represents a hydrogen atom, the radical of formula: or a radical suitable for the synthesis of polynucelotides and R5 represents a hydrogen atom or the protected or unprotected hydroxyl OH radical.

专利号:US-9688644-B2
优先权日:2009-04-30
标 题 :Synthesis of Tetracyclines and intermediates thereto
发明人：MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.

专利号:US-2005014954-A1
优先权日:2001-11-22
标 题:Pyrrole synthesis
发明人：OHRLEIN REINHOLD; BAISCH GABRIELE
摘要:The invention relates to a novel process for the preparation of N-substituted pyrroles, especially of formula (V), wherein the radicals are as defined in the description, by intermolecular aza-Wittig reaction starting from organic azides and 1,4-dioxo compounds. The invention relates also to novel iminophosphorane intermediates for this synthesis. The resulting pyrroles are useful, for example, in the organic synthesis of pharmaceuticals or other active substances and chemicals.

专利号:US-8026383-B2
优先权日:2001-07-06
标题:Process for the preparation of intermediates useful in the synthesis of statin derivatives
发明人：OEHRLEIN REINHOLD; BAISCH GABRIELE; END NICOLE; BURKHARDT STEPHAN; STUDER MARTIN
权利人:BASF SE
摘要:The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I n nwherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH 3 )OCH 3 , R a is a hydroxy-protecting group and R b is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.