📜1,10-Dichlor-Decin-5置于palladium On Barium Sulfate 偶氮二异丁腈,氢气,三正丁基氢锡体系中,用 吡啶,苯 用作溶剂,化学反应 36.0H,反应生成戊基环戊烷 参考文献:Dodson,S.A.; Stipanovic,R.D.,Journal Of The Chemical Society. Perkin Transactions I,1975,P. 410-412 标题:Dodson,S.A.; Stipanovic,R.D.,Journal Of The Chemical Society. Perkin Transactions I,1975,P. 410-412
专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-4033949-A 优先权日:1976-04-14 标 题:Analogs of thromboxane B2 and processes for their synthesis 发明人:KELLY ROBERT C; NELSON NORMAN A 权利人:UPJOHN CO 摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-11a-oxa-PGF 2 .sub.α). These analogs are particularly and especially useful as reproductive cycle control agents.
专利号:EP-1253146-B1 优先权日:2001-04-27 标题 :Process for the synthesis of substituted furancarboxylates 发明人:POECHLAUER PETER; GANGLBERGER THORSTEN; MAYRHOFER HERBERT 权利人:DSM FINE CHEM AUSTRIA GMBH 摘要:Alkyl 4-amino-2-alkyl-5-substituted-furan-3-carboxylates (I) are prepared by reacting a hydroxy-nitrile of formula R1-CH(OH)-CN (II) with a beta -ketoacid ester (III) in the presence of a metal halide catalyst and an inert organic solvent at 0 - 120 degrees C, followed by removing the catalyst and recovering (I).. Alkyl 4-amino-2-alkyl-5-substituted-furan-3-carboxylates of formula (I) are prepared by reacting a hydroxy-nitrile of formula R1-CH(OH)-CN (II) with a beta -dicarbonyl compound of formula R2-CO-CH2-COOR3 (III) in the presence of a metal halide catalyst and an inert organic solvent at 0 - 120 degrees C, followed by removing the catalyst and recovering (I). R1 = 1-18C alkyl, alkenyl or alkynyl (all optionally substituted by inert groups), or an optionally substituted aromatic or heterocyclic group; and R2, R3 = 1-4C alkyl.
专利号:WO-9729091-A1 优先权日:1996-02-09 标题:Balanol analogues 发明人:NIELSEN JOHN; LYNGSOE LARS OLE 权利人:AUDA PHARMACEUTICALS APS; NIELSEN JOHN; LYNGSOE LARS OLE 摘要:The present invention relates to a solid phase methodology for the preparation of a combinatorial library of structural analogues of the natural product balanol (ophiocordin, azepinostatin), which is a protein kinase C (PKC) and protein kinase A (PKA) inhibitor. The method comprises solid-phase synthesis of the analog variants of balanol whereby a high molecular diversity is introduced. The synthetic scheme is based on a retrosynthetic analysis of the native structure which revealed three main building blocks suitable as templates for modification. The dicarboxy-functional moiety can be immobilised to the polymer support either as the monoallyl ester or as the internal anhydride. The libraries produced by the method are especially suited for high throughput screening of potential drug candidates for the treatment of mammals, especially humans.
专利号:US-4070384-A 优先权日:1976-04-14 标 题 :Process for preparing thromboxane B compounds from prostaglandin fα co 发明人:SCHNEIDER WILLIAM P 权利人:UPJOHN CO 摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-lla-oxa-PGF 2 α). These analogs are particularly and especially useful as reproductive cycle control agents.
专利号:US-4052552-A 优先权日:1976-08-20 标 题:Thromboxane b analogs 发明人:SCHNEIDER WILLIAM P 权利人:UPJOHN CO 摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-11a-oxa-PGF 2 α). These analogs are particularly and especially useful as reproductive cycle control agents.
参考文献:10.1007/bf02321771 参考文献:10.1007/bf00523731 摘要:Vitvitskii AI. Calculation of heats of formation for carbocyclic compounds. Theoretical and Experimental Chemistry. 1969 Jan;3(1):44–7. doi: 10.1007/bf00523731. 参考文献:10.1023/b:hite.0000033879.33552.f9 摘要:Sagadeev EV, Sagadeev VV. Calculation of the Heat of Combustion of Hydrocarbon Components of Fuels. High Temperature. 2004 May;42(3):421–5. doi: 10.1023/b:hite.0000033879.33552.f9. 参考文献:10.1007/bf02297862 摘要:Rang S, Orav A, Kunigas K, Eisen O. Capillary gas chromatography of monosubstituted cyclopentenes and cyclohexenes. Chromatographia. 1977 Mar;10(3):115–22. doi: 10.1007/bf02297862. 参考文献:10.1007/s12404-008-0027-z 摘要:Gao Z, Liu L, Zhu X, Li W. The composition analysis of coal-derived light oil. Journal of Coal Science and Engineering (China). 2008 Mar;14(1):136–9. doi: 10.1007/s12404-008-0027-z.