专利号:WO-2008053517-A1 优先权日:2006-10-30 标题 :Agent for promoting in vivo dha synthesis and seaweed oil 发明人:MIYASHITA KAZUO; HOSOKAWA MASASHI; SASHIMA TOKUTAKE; SASAKI TAKANORI 权利人:UNIV HOKKAIDO NAT UNIV CORP; MARINE TEC KAMAISHI INC; MIYASHITA KAZUO; HOSOKAWA MASASHI; SASHIMA TOKUTAKE; SASAKI TAKANORI 摘要:It is intended to provide an agent for promoting in vivo DHA synthesis and a seaweed oil which enable the supplementation of DHA to a living body instead of taking oxidizable DHA as a fish oil. According to the agent for promoting in vivo DHA synthesis and the seaweed oil which contain fucoxanthin, even if oxidizable DHA is not taken as a fish oil, an activity of in vivo DHA synthesis can be increased by taking fucoxanthin or the seaweed oil containing fucoxanthin, whereby the supplementation of DHA to a living body can be substituted. Further, by adding this fucoxanthin or seaweed oil containing fucoxanthin to a food material, medicinal product or feed, the food material, medicinal product or feed which has a function to promote in vivo DHA synthesis can be provided.
专利号:WO-2023248205-A1 优先权日:2022-06-23 标 题 :Novel ruthenium complexes, method of their synthesis, intermediate compounds used in this method, method of their synthesis and the use of novel ruthenium complexes in olefin metathesis reactions 发明人:GRELA KAROL; KAJETANOWICZ ANNA; SYTNICZUK ADRIAN; MILEWSKI MARIUSZ; PUROHIT VISHAL; STRUZIK FILIP 权利人:UNIV WARSZAWSKI 摘要:The subject of the invention is a novel ruthenium complex with the general formula Ru-1, in which all the variables have the meaning defined in the disclosure. The subject of the invention is also a synthesis method of the ruthenium complex, an intermediate which is a precursor of the ligand used in the synthesis reactions of the ruthenium complex CAAC-1 and application of this ruthenium complex as a (pre)catalyst in olefin metathesis reactions.
专利号:US-2017211119-A1 优先权日:2014-07-25 标 题 :In vivo production of a recombinant carotenoid-protein complex 发明人:BOURCIER DE CARBON CÉLINE; KIRILOVSKY DIANA; BOULAY CLÉMENCE; DURAN BERTRAND-ELIE; PHULPIN ALEXANDRE; WILSON ADJÉLÉ 权利人:PHYCOSOURCE; Commissariat A L'Enerigie Atomique et Aux Energies Alteratives; CENTRE NAT DE LA RECH SCIENT (CNRS); COMMISSARIAT ENERGIE ATOMIQUE; CENTRE NAT RECH SCIENT 摘要:The present invention relates to a method for producing a carotenoid-protein complex in vivo comprising the steps of transforming of prokaryote cell with genes involved in carotenoid synthesis and with a gene encoding an apo-carotenoprotein; culturing said prokaryote cells such as to induce sequential genes expression, isolating and purifying the carotenoid-protein complex.
专利号:US-2007036742-A1 优先权日:2005-08-09 标题 :Methods and compositions for modulating hair growth or regrowth 发明人:ROUFS JAMES B; DUVEL LANE A; FAST DAVID J; GLYNN KELLY M 权利人:ACCESS BUSINESS GROUP INT LLC 摘要:The present invention relates to compositions and methods for modulating hair growth or regrowth. The compositions of the present invention comprise extracts of one or more of the following: Boswellia serrata, Undaria pinnatifida, green tea (e.g., Camellia sinensis ), shiso, Pureraria mirifica, luteolin (e.g. Perilla ocymoides leaf extract), astilbin, vitamin E, amentoflavone, tetrahydropiperine, licochalcone, astaxanthin, red clover, Brassica juncea, unfermented green rooibos, enzyme CoQ10, salvia, ximenynic acid, hops oleoresin, apple, soy, saw palmetto, or ellagic extract, or any derivative thereof. In particular, the compositions and methods of the present invention can be used to stimulate or increase hair growth and/or prevent or slow the loss of hair by having one or more of the following functions: (a) inhibiting synthesis of DHT; (b) inhibiting proteasomal activity; (c) inhibiting IL-1 activity; (d) increasing vascularization; (e) increasing expression of vascular endothelial growth factor; (f) increasing expression of keratinocyte growth factor; (g) inhibiting inflammation; or (h) acting as an antibacterial.
专利号:US-11643418-B2 优先权日:2013-11-04 标题:Macrocyclization reactions and intermediates and other fragments useful in the synthesis of analogs of halichondrin B
专利号:US-2023095259-A1 优先权日:2020-06-01 标 题:Synthesis of pheromone derivatives via z-selective olefin metathesis
1: Jin Y, Qiu S, Shao N, Zheng J. Fucoxanthin and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Synergistically Promotes Apoptosis of Human Cervical Cancer Cells by Targeting PI3K/Akt/NF-κB Signaling Pathway. Med Sci Monit. 2018 Jan 1;24:11-18. 2: Ye GL, Du DL, Jin LJ, Wang LL. Sensitization of TRAIL-resistant cervical cancer cells through combination of TRAIL and fucoxanthin treatments. Eur Rev Med Pharmacol Sci. 2017 Dec;21(24):5594-5601. doi: 10.26355/eurrev_201712_14000. doi: 10.1021/acs.jafc.7b03931. Epub 2017 Dec 8. 5: Chang YH, Chen YL, Huang WC, Liou CJ. Fucoxanthin attenuates fatty acid-induced lipid accumulation in FL83B hepatocytes through regulated Sirt1/AMPK signaling pathway. Biochem Biophys Res Commun. 2018 Jan 1;495(1):197-203. doi: 10.1016/j.bbrc.2017.11.022. Epub 2017 Nov 4. doi: 10.1007/s13577-017-0188-4. Epub 2017 Nov 6. doi: 10.1002/asia.201701296. Epub 2017 Nov 2. doi: 10.1155/2017/6792543. Epub 2017 Aug 8.
合成参考文献
参考文献:10.1124/dmd.32.2.205 摘要:Asai A, Sugawara T, Ono H, Nagao A. Biotransformation of fucoxanthinol into amarouciaxanthin A in mice and HepG2 cells: formation and cytotoxicity of fucoxanthin metabolites. Drug Metab Dispos. 2004 Feb;32(2):205–11. doi: 10.1124/dmd.32.2.205.