专利号:US-8633182-B2 优先权日:2012-05-30 标题:Indanyloxyphenylcyclopropanecarboxylic acids 发明人:HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN 权利人:HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN; BOEHRINGER INGELHEIM INT 摘要:The present invention relates to compounds of general formula I, n nwherein the groups R 1 , R 2 , R 3 , m and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
专利号:US-7691843-B2 优先权日:2002-07-11 标 题 :N-hydroxyamide derivatives possessing antibacterial activity 发明人:RAJU BORE G; O'DOWD HARDWIN; GAO HONGWU; PATEL DINESH V; TRIAS JAOQUIM 权利人:PFIZER 摘要:Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.
专利号:CN-119100946-A 优先权日:2024-08-30 标题 :Synthesis method of key intermediate of rilpivirine
参考文献:10.1007/bf00675790 摘要:Domenicano A, Schultz G, Hargittai I, Colapietro M, Portalone G, George P, Bock CW. Molecular structure of nitrobenzene in the planar and orthogonal conformations. Structural Chemistry. 1990 Jan;1(1):107–22. doi: 10.1007/bf00675790.