CAS: 27490-70-6; Chloro-Dimethyl-(2-Methylpropyl)Silane

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CAS号75-78-5 二甲基二氯硅烷 | CAS号1066-35-9 二甲基一氯硅烷 | CAS号1888-87-5 二氯异丁基铝

三异丁基铝,二氯二甲基硅烷置于bis(η3-Allyl-μ-Chloropalladium(II)),2-二环己膦基-2'-(N,N-二甲胺)-联苯体系中,用 1,4-二氧六环,正己烷 用作溶剂,化学反应 18.0H,以47%的收率获得氯化二甲基异丁基硅烷
参考文献:由二,三和四氯硅烷通用合成和选择性合成甲基一氯硅烷
标题:由二,三和四氯硅烷通用合成和选择性合成甲基一氯硅烷
摘要:由于难以裂解牢固的si-Cl键,氯硅烷直接催化转化为有机硅化合物仍然具有挑战性.我们在本文中报道了氯硅烷与有机铝试剂的钯催化交叉偶联反应.[pd(c 3 H 5)cl] 2和davephos配体的组合催化了各种二氯硅烷1,三氯硅烷5和四氯硅烷6的选择性甲基化,得到了相应的一氯硅烷.
Doi:10.1021/acs.Orglett.0C04175

专利信息

专利号:WO-2014140006-A1
优先权日:2013-03-11
标 题:Process for enantioselective synthesis of 3-hydroxy-glutaric acid monoesters and use thereof
发明人：KÖNIG BURGHARD; WETTERICH FRANK; GRÖGER HARALD; METZNER RICHARD
权利人:SANDOZ AG; UNIVERSITÄT BIELEFELD
摘要:The present invention relates to a process for the enzymatic enantioselective synthesis of 3-hydroxy- glutaric acid esters of formula 1 with R 1 being alkyl, aryl, or substituted alkyl, as well as the use compounds of formula 1 in the synthesis.

专利号:WO-0200681-A1
优先权日:2000-06-27
标题 :20-fluoro-17(20)-vinyl steroids as inhibitors of c17-20-lyase and 5-alpha reductase
发明人：PEET NORTON P; WEINTRAUB PHILIP M; BURKHART JOSEPH P; GATES CYNTHIA A
权利人:AVENTIS PHARMA INC; PEET NORTON P; WEINTRAUB PHILIP M; BURKHART JOSEPH P; GATES CYNTHIA A
摘要:The invention related to 20κ-fluoropregna-4,17(20)-dien-3-on-21-oic acid ethyl ester, 20κ-fluoro-3β-hydroxypregna-4,17(20)-dien-21-oic acid ethyl ester, 20κ-fluoro-21-hydroxypregna-4,17(20)-dien-3-one, 20κ-fluoropregna-4,17(20)-dien-3β,21-diol and related compounds and to compositions incorporating these compounds, as well as the inhibition of C17,20 lyase, 5α-reductase and C17-hydroxylase, and to the use of these compounds in the treatment of androgen and estrogen mediated or dependent disorders, including benign prostatic hyperplasia, prostate cancer, breast cancer and DHT-mediated disorders such as acne and hirsutism. Treatment of disorders related to the over synthesis of cortisol, for example, Cushing's Syndrome are also included. The treatment of androgen-dependent disorders also includes a combination therapy with known androgen-receptor antagonists, such as flutamide. The compounds of the invention have general formulae (I).

专利号:US-2022355262-A1
优先权日:2019-07-22
标题 :System and method for manufacturing water-based hydrophobic aerogels and aerogel composites
发明人：SACHITHANADAM MAHESH; KHORASGANI SOGHRATI ELMIRA; NATARAJAN GAYATHRI
权利人:KROSSLINKER PTE LTD
摘要:Embodiments of the present invention provide users with a system and method for manufacturing water-based hydrophobic aerogels and aerogel composites. The system and method can be carried out in a manner which is more rapid than typical ways and can be readily scalable. The method of manufacture is useful for producing water based hydrophobic aerogels and aerogel composites on a large scale with good homogeneity and consistency. Advantageously, the method of manufacture also has the benefit of a shorter processing time due to the vacuum homogenizing and mixing processes, the use of microwave assisted vacuum freeze drying for ease of synthesis of water-based hydrophobic aerogels.

专利号:US-5998612-A
优先权日:1981-10-23
标 题 :Antibiotic synthesis
发明人：REIDER PAUL J; GRABOWSKI EDWARD J J
摘要:A method of preparing intermediates for carbapenem antibiotics characterized by treating a N-deprotected acetoxy conpound of the formula: ##STR1## in the presence of a Lewis acid or a silylating agent to yeild an intermediate; and cyclizing the intermediate in the presence of rhodium (II) acetate to form a bicyclic ketoester.

专利号:US-5071966-A
优先权日:1989-01-12
标 题 :Process for preparing an enol silyl ether compound
发明人：KAN KAZUNORI; MURAKAMI HIROSHI; NAGASHIMA NOBUO; UEYAMA NOBORU; OHASHI TAKEHISA
权利人:KANEGAFUCHI CHEMICAL IND
摘要:A process for preparing an enol silyl ether compound from a diazoacetoacetic acid ester having the general formula (IV): ##STR1## wherein R 1 is a lower alkyl group having 1 to 6 carbon atoms, phenyl group, a substituted phenyl group, an aralkyl group or allyl group, and R 2 , R 3 and R 4 are the same or mutually different and each is a lower alkyl group having 1 to 6 carbon atoms, which comprises reacting a diazoacetoacetic acid ester having the general formula (I): ##STR2## wherein R 1 is the same as defined above, with a trialkylsilyl chloride having the general formula (II): ##STR3## wherein R 2 , R 3 and R 4 are the same as defined above, in an inert solvent in the presence of an organic base and an alkali halide having the general formula (III): n n MX (III) n n wherein M is an alkaline metal and X is bromine atom or iodine atom. The desired compound is useful as an intermediate for synthesis of carbapenem β-lactam antibiotics.

专利号:EP-2280987-A2
优先权日:2008-04-08
标 题:Triterpene saponins, methods of synthesis, and uses thereof