CAS: 2338-03-6; (S)-2-Amino-4-Oxobutanoic Acid

上下游产品

(S)-N-Cbz-aspartic acid semialdehyde (E)-(S)-2-Amino-4-methoxy-but-3-enoic acid L-methionine tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoateDL-Homoserine lactate anion

📜(S)-(-)-2-氨基-4-戊烯酸置于盐酸,臭氧体系中,用 水 用作溶剂,化学反应 1.0H,反应生成(2S)-2-氨基-4-氧代丁酸
参考文献:Mtb-Asadh酶小分子抑制剂的生物学评估
标题:Mtb-Asadh酶小分子抑制剂的生物学评估
摘要:在我们以前的工作中,使用药物信息学方法鉴定了mtb-Asadh的一些有希望的命中物.总共选择了十种化合物用于针对mtb-Asadh的生物学评估,其中九种是从基于形状和药效团模型的虚拟筛选中选择的,其余一种是通过类似物设计设计的.据报道,半胱氨酸是晶体结构中mtb-Asadh的共价结合抑制剂(pdb Id:3Tz6).十分之六的化合物显示出对mtb-Asadh的非常好抑制作用.所有这六个分子zinc00108239,Zinc36358489,Nsc4862,Nsc109187,Nsc51108,Nsc226144和s-羧甲基-L-半胱氨酸均显示ic 50值范围从65-100 µm.S-羧甲基-L-半胱氨酸的结合模式分析在被测化合物中显示出最高的抑制活性,表现出与催化残基arg99,Arg249,Lys227和his256的结合相互作用.这些研究可进一步用于线索优化和合理的药物设计,以找到抗结核的新线索.
Doi:10.2174/1570180813666160617102813

专利信息

专利号:US-9062314-B2
优先权日:2008-12-12
标题 :Biological synthesis of difunctional alkanes from carbohydrate feedstocks
发明人：BAYNES BRIAN M; GEREMIA JOHN MICHAEL
权利人:CELEXION LLC
摘要:Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.

专利号:US-9102961-B2
优先权日:2009-03-11
标 题 :Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
发明人：BAYNES BRIAN M; GEREMIA JOHN MICHAEL; LIPPOW SHAUN M
权利人:CELEXION LLC
摘要:Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.

专利号:US-2015317458-A1
优先权日:2012-12-06
标 题 :In silico prediction of enhanced nutrient content in plants by metabolic modelling
发明人：LOTZ KATRIN; LEPS MICHAEL; LEMKE RAINER; JUNKER BJOERN; SCHREIBER FALK
权利人:BASF PLANT SCIENCE CO GMBH
摘要:The present invention relates to a method for identifying at least one metabolic conversion step, the modulation of which increases the amount of a metabolite of interest in a plant cell, plant or plant part, said method comprising establishing a stoichiometric network model for the metabolism of the plant cell, plant or plant part including the synthesis pathway for the metabolite of interest, identifying at least one candidate metabolic conversion step by applying at least one algorithm of Growth-coupled Design, and validating the at least one candidate metabolic conversion step by a constraint-based modeling approach in the stoichiometric network model, wherein an increase in the metabolite of interest occurring in said constraint-based modeling approach is indicative for a metabolic conversion step, the modulation of which increases the amount of the metabolite of interest in the plant cell, plant or plant part. The present invention further relates to a method for generating a plant cell, plant or plant part which produces an increased amount of a metabolite of interest when compared to a control, said method comprising identifying a metabolic conversion step, the modulation of which increases a metabolite of interest in a plant cell, plant or plant part, by the method for identifying a metabolic conversion step and modulating the said metabolic conversion step such that the amount of the metabolite of interest is increased in vivo in a plant cell, plant or plant part.

专利号:US-11535876-B2
优先权日:2017-01-09
标 题 :Xylose-induced genetically engineered bacteria used for producing ectoine and use thereof
发明人：XIE XIXIAN; WU XUEJIAO; CHEN NING; YAN FANGQING; MA QIAN; MA JIE; ZHANG HONGCHAO
权利人:TIANJIN UNIV OF SCIENCE AND TECHNOLOGY
摘要:The present disclosure relates to the field of genetic engineering, especially relates to a xylose-induced genetically engineered bacteria used for producing ectoine as well as a construction method and use thereof. The genetically engineered bacteria is constructed by heterologously expressing the ectABC gene cluster from Halomonas elongata on the E. coli chromosome, using the promoter of xylose transporter coding gene xylF to control the RNA polymerase from T7 bacteriophage, reconstructing a synthesis pathway of ectoine and constructing a plasmid-free system, and enhancing the expression of target genes by a strong promoter T7; the yield of ectoine reached 12-16 g/L after 20-28 h fermentation in shake flask, and reached 35-50 g/L after 24-40 h fermentation in a 5 L fermentor.

专利号:US-2012258504-A1
优先权日:2008-12-12
标题:Biological synthesis of difunctional alkanes from carbohydrate feedstocks

专利号:US-2013017593-A1
优先权日:2009-03-11
标题:Biological Synthesis of Difunctional Hexanes and Pentanes from Carbohydrate Feedstocks