CAS: 23056-40-8; 2-Chloro-5-Methyl-3-Nitropyridine

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34552-13-1 58596-88-6 160906-98-9

上下游产品

CAS号7464-14-4 2-羟基-5-甲基-3-硝基吡啶 | CAS号1003-68-5 2-羟基-5-甲基吡啶 | CAS号1603-41-4 2-氨基-5-甲基吡啶 | CAS号106690-38-4 2-甲基氨基-5-甲基-3-硝基吡啶 | CAS号33252-62-9 2-甲氧基-5-甲基-3-硝基砒啶 | CAS号179677-17-9 3-Pyridinamine,... | CAS号34552-13-1 5-甲基-3-氨基-2-氯吡啶 | CAS号29393-73-5 [1,2,5]Oxadiazo... | CAS号21901-25-7 2-肼基-5-甲基-3-硝基砒啶 | CAS号6960-20-9 3-甲基-5-硝基砒啶 | CAS号7477-10-3 6-氯-5-硝基烟酸 | CAS号137320-34-4 2-(3-hydroxy-1H... | CAS号2047-49-6 5-硝基烟酸

2-羟基-5-甲基嘧啶置于氯化亚砜,硫酸,硝酸体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应 21.0H,反应生成2-氯-5-甲基-3-硝基吡啶
参考文献:作为氨基糖原合酶激酶3(gsk-3)抑制剂的8-氨基-[1,2,4]三唑并[4,3-A ]吡啶-3(2 H)-One衍生物的合成与评价
标题:作为氨基糖原合酶激酶3(gsk-3)抑制剂的8-氨基-[1,2,4]三唑并[4,3-A ]吡啶-3(2 H)-One衍生物的合成与评价
摘要:通过建模,合成设计了新的强力糖原合酶激酶3(gsk-3)抑制剂8-氨基-[1,2,4]三唑并[4,3-A ]吡啶-3(2 H)-One衍生物.并进行了体外评价.化合物17C在基于酶和细胞的测定中显示出非常好的效价(ic 50 = 111 Nm,Ec 50 = 1.78μm).此外,已证明其具有理想的水溶性,Pk曲线和适度的大脑渗透能力.
Doi:10.1016/j.Bmcl.2013.03.119

专利信息

专利号:US-8188282-B2
优先权日:2006-07-15
标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

专利号:EP-2173747-B1
优先权日:2007-06-26
标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:AU-2007276514-A1
优先权日:2006-07-15
标题:A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CA-2693142-A1
优先权日:2007-06-26
标题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles

专利号:CA-2657717-A1
优先权日:2006-07-15
标 题 :A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:AU-2008267443-A1
优先权日:2007-06-26
标 题 :A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles