CAS: 228419-13-4; 3-(Benzyloxy)Benzohydrazide

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ethyl 3-(benzyloxy)benzoate methyl 3-hydroxybenzoate benzyl bromide ethyl-3-hydroxybenzoate 3-(benzyloxy)benzoic acid 2-(2-cyanoethyl)hydrazide 5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione 5-(3-benzyloxyphenyl)-1,3,4-oxadiazol-2-one 2-(3-hydroxyphenyl)-1,3,4-oxadiazole

📜3-羟基苯甲酸乙酯置于potassium Carbonate,一水合肼体系中,用 乙醇,丙酮 用作溶剂,化学反应 31.0H,反应生成3-苄氧基苯甲酰肼
参考文献:Synthesis And Biological Screening Of 2-Substituted 5,6-Dihydro-5-Oxo-4H-1,3,4-Oxadiazine-4-Propanenitriles And Of Their Intermediates
标题:Synthesis And Biological Screening Of 2-Substituted 5,6-Dihydro-5-Oxo-4H-1,3,4-Oxadiazine-4-Propanenitriles And Of Their Intermediates
摘要:To Evaluate The Effect Of Substituents On Biological Activities Of Electron-Rich N-Containing Heterocycles,The Variably 2-Substituted 5,6-Dihydro-5-Oxo-4H-1,3,4-Oxadiazine-4-Propanenitriles 26-33 Were Synthesized And Evaluated For Antibacterial,Antifungal,And Enzyme-Inhibition Activities. The Target Compounds Were Obtained From Alkyl 4-Or 3-Hydroxy Benzoates 1 And 2,Respectively,And From Methyl Indoleacetate 3. The Phenolic Oh Group Of Benzoates I And 2 Were Substituted With P-Toluenesulfonyl (--> 4 And 5),Benzoyl ( 6 And 7),And Benzyl Groups ( 8 And 9) And Then Converted To 5,6-Dihydro-5-Oxo-4H-1,3,4-Oxadiazine-4-Propanenitriles. To Establish Structure-Activity Relationships (Sar),A Pharmacological Screening Of The Intervening Intermediates Was Also Conducted,Which Revealed That The Intermediate Hydrazide 11 Possesses Significant Antimicrobial And Mao-A Inhibiting Properties And Intermediates 12,24,28,And 29 Appreciable Antifungal Activities. Compound 7 Inhibits A-Chymotrypsin.
Doi:10.1002/1522-2675(200202)85:2<559::Aid-Hlca559>3.0.Co;2-A