CAS: 2162-31-4; 2-((Tetrahydro-2H-Pyran-2-yl)Oxy)Ethanol

相似化合物

107-21-1 61675-94-3 60221-37-6

上下游产品

H-pyran3,4-dihydro-2H-pyran ethylene glycol ethane1-(tetrahydropyranyloxy)-2-(p-tolylsulfonyl)oxyethane 2-methoxytetrahydropyran ethylene glycol 4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phthalonitrile

📜Tert-Butyldimethyl(2-((Tetrahydro-2H-Pyran-2-yl)Oxy)Ethoxy)Silane置于samarium(III) Chloride体系中,用 乙醇 用作溶剂,化学反应 40.0H,以85%的收率获得2-(四氢-2H-吡喃-2-氧基)乙醇
参考文献:Highly Chemoselective Esterification Reactions And Boc/thp/tbdms Discriminating Deprotections Under Samarium(III) Catalysis
标题:Highly Chemoselective Esterification Reactions And Boc/thp/tbdms Discriminating Deprotections Under Samarium(III) Catalysis
摘要:The Usefulness Of Smcl(3) As An Excellent Catalyst For Chemoselective Esterifications And Selective Removal Of Acid Sensitive Protecting Groups Such As B°C,Thp,And Tbdms In The Presence Of One Another Is Demonstrated Through Suitable Examples.
Doi:10.1021/ol200247C

专利信息

专利号:US-8329958-B2
优先权日:2004-07-02
标 题:Combinatorial synthesis of PEG oligomer libraries
发明人：RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N
权利人:RIGGS-SAUTHIER JENNIFER A; EKWURIBE NNOCHIRI N; BIOCON LTD
摘要:A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.

专利号:US-2010184989-A1
优先权日:2007-03-12
标 题 :De Novo Synthesis of Conjugates
发明人：RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J
权利人:NEKTAR THERAPEUTICS
摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.

专利号:US-8940855-B2
优先权日:2009-06-02
标题:Polymers bearing pendant pentafluorophenyl ester groups, and methods of synthesis and functionalization thereof
发明人：HEDRICK JAMES L; NELSON ALSHAKIM; SANDERS DANIEL P
权利人:IBM
摘要:A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.

专利号:US-2006008850-A1
优先权日:2004-07-02
标 题 :Combinatorial synthesis of PEG oligomer libraries

专利号:WO-2008068614-A2
优先权日:2006-12-06
标题 :Stereoselective synthesis of 1-[6-ethyl-1,2-dihydroxy-propyl)-pyridin-3-yl]-3-[2-(4-methyl-piperazin-1-yl)-benzyl]-pyrrolidin-2-one

专利号:US-8268959-B2
优先权日:2004-09-23
标 题 :Energetic polyphosphazenes
发明人：GOLDING PETER; TRUSSELL STEPHEN JOHN; COLCLOUGH MARTIN EAMON; HAMID JAVID
权利人:GOLDING PETER; TRUSSELL STEPHEN JOHN; COLCLOUGH MARTIN EAMON; HAMID JAVID; SECR DEFENCE
摘要:This invention describes the synthesis and use of novel energetic poly(phosphazene) materials suitable for binding high explosives. These materials may also be used as explosives in their own right. The materials possess high energy density and are highly amenable to chemical modification thereby allowing for modification to the physical properties of the material. In particular the tacky and rubbery nature of these materials makes them ideal for use as binder and co-binder materials.