CAS: 19883-57-9; (S)-2-Amino-2-(4-Fluorophenyl)Acetic Acid

相似化合物

93939-74-3 7292-73-1 142186-36-5

上下游产品

CAS号153381-37-4 N-乙酰基-2-(4-氟苯基)-甘氨酸 | CAS号144744-29-6 (3R,5S,6R)-2,3,... | CAS号459-57-4 对氟苯甲醛 | CAS号7292-73-1 2-氨基-2-(4-氟苯基)乙酸 | CAS号24843-89-8 (R)-2-azido-2-(... | CAS号394-56-9 2,2,2-trichloro... | CAS号339274-32-7 (R)-2,2,2-trich... | CAS号142186-36-5 (S)-2-((叔丁氧基羰基)... | CAS号174770-74-2 (R)-2-氨基-2-(4-氟苯基)乙醇 | CAS号170902-74-6 2-氨基-2-(4-氟苯基)乙...

2-<(2-Hydroxy-1-Phenylethyl)Amino>-2-(4-Fluorophenyl)Ethanenitrile置于lead(Iv) Acetate,盐酸,氯化亚砜体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 37.3H,反应生成L-4-氟苯甘氨酸
参考文献:使用 (R)-Phenylglycinol 作为手性助剂高效实用合成 L-α-氨基酸
标题:使用 (R)-Phenylglycinol 作为手性助剂高效实用合成 L-α-氨基酸
摘要:包括 L-α-芳基甘氨酸在内的 L-α-氨基酸可以通过 (R)-2-氨基-2-苯基乙醇与醛和氰化氢的 Strecker 反应得到的 α-氨基腈方便地立体选择性地合成.这些α-氨基腈的立体选择性受热力学控制.
Doi:10.1246/bcsj.65.2359

专利信息

专利号:US-6177564-B1
优先权日:1998-09-11
标题:Process for the synthesis of N-benzyl-3-(4-fluorophenyl)-1-4-oxazin-2-one
发明人：NELSON TODD D; BHUPATHY MAHADEVAN
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of N-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one of the formula:This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity, in particular, as substance P (neurokinin-1) receptor antagonists.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:US-6046325-A
优先权日:1998-09-11
标 题:Chemical synthesis of 1,4-oxazin-2-ones
发明人：ASHWOOD MICHAEL STEWART; BISHOP BRIAN CHRISTOPHER; COTTRELL IAN FRANK
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a process for the preparation of a compound of formula (I): ##STR1## wherein R 1 is a C 1-6 alkyl or arylC 1-4 alkyl group; and R 2 is a hydrogen atom, a halogen atom, or a group selected from C 1-6 alkyl, CF 3 or C 1-6 alkoxy substituted by C 1-4 alkoxy; which comprises reacting an anhydrous or hydrated glyoxal of formula (II) with a compound of formula (III): ##STR2## in the presence of an acid.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.