专利号:US-9206209-B2 优先权日:2010-10-19 标 题:Nucleotide analogue, method of synthesis of nucleotide analogue, use of nucleotide analogue, antiviral pro-nucleotide, pharmaceutical composition 发明人:KRASZEWSKI ADAM; ROMANOWSKA JOANNA; SOBKOWSKI MICHAL; SZYMANSKA-MICHALAK AGNIESZKA; STAWINSKI JACEK; BORYSKI JERZY; LIPNIACKI ANDRZEJ; PIASEK ANDRZEJ 权利人:KRASZEWSKI ADAM; ROMANOWSKA JOANNA; SOBKOWSKI MICHAL; SZYMANSKA-MICHALAK AGNIESZKA; STAWINSKI JACEK; BORYSKI JERZY; LIPNIACKI ANDRZEJ; PIASEK ANDRZEJ; INST CHEMII BIOORG PAN; NARODOWY INST LEKOW 摘要:An exemplary emboidment is related to a pharmaceutical composition of the class of nucleotide analogues and antiviral pro-nucleotides useful in partial or complete inhibition of human immunodeficiency virus (HIV). An exemplary embodiment is expressed in the formula (XVI): n nwhere X stands for N 3 and B stands for thymidine-1-yl, or X stands for H and B stands for uracil-1-yl or adenin-1-yl or hypoxanthin-1-yl.A method of synthesis of the nucleotide analogue using a phosphorylating agent for synthesis of the nucleotide analogue is provided.
专利号:US-2010087658-A1 优先权日:1996-08-06 标 题 :Methods and intermediates for synthesis of selective dpp-iv inhibitors 发明人:CAMPBELL DAVID ALAN; LEITAO EMILIA P T; WU ZHEN-PING; WANG PENG 权利人:PHENOMIX CORP 摘要:Methods and intermediates for the synthesis of selective inhibitors of dipeptidyl peptidase IV (DPP-IV) are provided. Coupling of a carboxylate salt with a boro-proline derivative provides a protected form of a DPP-IV inhibitor, which may be deblocked to yield the medicinal compound. The carboxylate salt can be a crystalline form of a sodium salt or a dicyclohexylammonium salt. The inhibitor can be used in the treatment of diabetes.
专利号:US-4818816-A 优先权日:1981-04-28 标 题:Process for the organic synthesis of oligosaccharides and derivatives thereof 发明人:PETITOU MAURICE; JACQUINET JEAN-CLAUDE; SINAY PIERRE; CHOAY JEAN; LORMEAU JEAN-CLAUDE; NASSR MAHMOUD 权利人:CHOAY SA 摘要:The invention relates to a process for the organic synthesis of oligosaccharides constituting or comprising fragments of acid mucopolysaccharides comprising the reaction of two compounds constituted or terminated by units of glucosamine structure and of uronic acid structure respectively, said units being specifically substituted. This process particularly enables valuable anticoagulant drugs to be obtained.
专利号:US-2007128509-A1 优先权日:2005-12-05 标 题:Producing sodium borohydride with high energy efficiency and recycles of by-product materials 发明人:HONG ZONGXUAN 权利人:HONG ZONGXUAN 摘要:A method for synthesizing sodium borohydride compound with reduced energy usage and recycles of by-product materials involved in the application and synthesis processes of sodium borohydride is disclosed. The method utilizes a sodium-sulfur electrochemical cell flow system for synthesizing sodium metal and incorporates the sodium metal produced in the commercial sodium borohydride synthesis processes known in prior arts, for example, the “Schlesinger processâ€?. Furthermore, the by-product materials involved in the application and synthesis of sodium borohydride are recycled through a series of processes.
专利号:US-2021369846-A1 优先权日:2018-10-26 标 题 :New Ammonium Salts Of Fluorinated Organic Acids, Method Of Their Synthesis and Application 发明人:STEFANEK AGATA; CIACH TOMASZ; LECZYCKAWILK KATARZYNA; CZARNOCKA-SNIADALA SYLWIA; GRAFSTEIN JOANNA; DRESLER MAGDALENA; NOWAK ALEKSANDRA; WGLINKSKI JAKUB 权利人:NANOSANGUIS 摘要:The exemplary arrangements relate to ammonium salts of partially fluorinated organic acids. The exemplary arrangements also relate to methods of synthesis of the ammonium salts of partially fluorinated organic acids. The exemplary arrangements also relate to methods of use of the ammonium salts of partially fluorinated organic acids to produce stabilizing emulsions of the oil-in-water and/or water-in-oil type. The exemplary arrangements also relate to methods of use and applications of the ammonium salts of partially fluorinated organic acids, for example use as stabilizing agents in blood substitute preparations.
专利号:US-6596256-B1 优先权日:2000-08-28 标 题:Synthesis of low silicon sodium X zeolite 发明人:OJO ADEOLA F; FITCH FRANK R; BUELOW MARTIN; GITTLEMAN CRAIG S; JALE SUDHAKAR R 权利人:BOC GROUP INC 摘要:Low silicon sodium X zeolite containing little or no sodium A zeolite as by-product, is prepared by direct synthesis from sodium ion-containing hydrogels, the crystallization step being carried out by maintaining the hydrogels at a temperature below about 70° C., and preferably in the range of about 50 to about 70° C. for the duration of the crystallization step. Preferably, the ratios of components in the solutions used to make the hydrogel are such that in the hydrogel the silica/alumina molar ratio will be in the range of about 2.25:1 to about 2.4:1; the sodium oxide to silica molar ratio will be in the range 1.6:1 to about 1.9:1; and the water to sodium oxide molar ratio will be greater than about 60:1.
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