CAS: 1558-17-4; 4,6-Dimethylpyrimidine

该化合物是一种杂交有机化合物,其特征是具有两个甲基组,在4和6个位置上附着两个甲基组;其分子分子式为C7H8N2,分子重量约为136.15克/摩尔;该化合物一般无色可粉黄,可视温度和纯度而定,可粉黄黄色液体或固体;在乙醇和乙醚等有机溶剂中可溶解,但水溶性有限.4,6-二甲基丙烯胺因其在各种制药和农用化学合成中作为中间体的作用而著称.由于环内存在氮原子,可参与质子反应,该物质具有基本特性.此外,该化合物还可进行各种化学变异,包括烷化和酶联,使其成为有机合成的多用途建筑块.安全数据表明,应谨慎处理该物质,因为它可能会引起皮肤和眼睛的刺激.

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合成工艺路线路线简述

    (4,6-Dimethylpyrimid-2'-yl)-Trimethylammonium Chloride置于乙酰胺,盐酸,水体系中,化学反应生成4,6-二甲基嘧啶
    参考文献:Heteroarylierungen Mit Quartrsubstituierten Pyrimidinsalzen
    标题:Heteroarylierungen Mit Quartrsubstituierten Pyrimidinsalzen
    摘要:
    Doi:10.1007/bf00917846

    专利信息


    专利号:US-4866175-A
    优先权日:1966-11-08
    标 题 :Novel process for the synthesis of quinoxaline and benzimidazole-N-oxides
    发明人:ISSIDORIDES COSTAS H; HADDADIN MAKHLUF J
    权利人:RESEARCH CORP
    摘要:The synthesis of quinoxaline and benzimidazole-N-oxides and of ester amd amide derivatives of 3-hydroxy-2-quinoxalinecarboxylic acid by a movel process consisting of the reaction between a benzofuroxan and an activated methylene-containing compound under basic conditions.

    专利号:US-4343942-A
    优先权日:1966-11-08
    标题:Quinoxaline derivatives
    发明人:ISSIDORIDES COSTAS H; HADDADIN MAKHLUF J
    权利人:RESEARCH CORP
    摘要:The synthesis of quinoxaline and benzimidazole-N-oxides and of ester and amide derivatives of 3-hydroxy-2-quinoxalinecarboxylic acid by a novel process consisting of the reaction between a benzofuroxan and an activated methylene-containing compound under basic conditions.

    专利号:EP-3070087-B1
    优先权日:2011-08-05
    标题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors

    专利号:EP-3070087-A1
    优先权日:2011-08-05
    标 题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors

    专利号:US-11518933-B2
    优先权日:2016-05-25
    标题:Precursor based method of synthesis and fabrication of hybrid lighting phosphors with high quantum efficiency, and significantly enhanced thermal and photostability
    发明人:LI JING; FANG YANG; LIU WEI
    权利人:UNIV RUTGERS
    摘要:Highly thermal and photo-stable inorganic-organic hybrid phosphor compounds, in which a copper (I) halide module is coordinated with a multi-dentate organic ligand. Also disclosed are semiconductor and light emitting devices comprising these materials, including light emitting diodes, and methods of preparing these materials and devices.

    专利号:US-6936600-B2
    优先权日:1999-04-01
    标题:Sorbitol dehrydrogenase inhibitors
    发明人:CHU-MOYER MARGARET Y; MYLARI BANAVARA L; ZEMBROWSKI WILLIAM J
    权利人:PFIZER
    摘要:This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, n n nwherein R 1 , R 2 and R 3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.
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    合成参考文献


    参考文献:10.1107/s1600536811012323
    摘要:Saeed S, Rashid N, Wong WT, Hussain R. 1-(4,6-Dimethyl-pyrimidin-2-yl)-3-(3,5-dinitro-benzo-yl)thio-urea monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1094.
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