5-溴戊酸置于氯化亚砜体系中,用 乙醇 用作溶剂,化学反应生成5-溴戊酸乙酯 参考文献:Diesters Of Carbonic Acid Endowed With Antiviral And Anti-Inflammatory 标题:Diesters Of Carbonic Acid Endowed With Antiviral And Anti-Inflammatory 摘要:碳酸二取代基的二酯,其与一级,二级或三级胺基形成的药用盐,以及它们作为抗病毒和抗炎药物的用途.
专利号:US-5306562-A 优先权日:1990-08-31 标 题 :Xanthenylamide handle for use in peptide synthesis 发明人:BARANY GEORGE 权利人:UNIV MINNESOTA 摘要:The preparation and properties of xanthenylamide handles for use in peptide synthesis is disclosed. The compounds, omega-(9-(9-fluorenylmethyloxycarbonyl)aminoxanthan-2-oxy)alkanoic acid derivatives, are used as peptide handles in the solid-phase synthesis of peptide amides.
专利号:US-2013296346-A1 优先权日:2010-11-23 标题 :Diphenyl-amine derivatives: uses, process of synthesis and pharmaceutical compositions 发明人:RODES SOLANES ROSA; GARCIA DOMINGUEZ NEFTALI; LOPEZ ORTEGA BEATRIZ; ALVAREZ DE MON SOTO MELCHOR; DE LA HERA MARTINEZ ANTONIO; MUNOZ MUNOZ ANA; LEDO GOMEZ FRANCISCO 权利人:RODES SOLANES ROSA; GARCIA DOMINGUEZ NEFTALI; LOPEZ ORTEGA BEATRIZ; ALVAREZ DE MON SOTO MELCHOR; DE LA HERA MARTINEZ ANTONIO; MUNOZ MUNOZ ANA; LEDO GOMEZ FRANCISCO; FAES FARMA SA 摘要:The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use as a medicament for treating inflammatory diseases.
专利号:US-9751851-B2 优先权日:2013-09-20 标 题:Molecules and compositions that inhibit gram negative bacteria and their uses 发明人:BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; CONRAD-MILLER LAURA C; O'LOUGHLIN COLLEEN T 权利人:UNIV PRINCETON; BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; MILLER LAURA C; O'LOUGHLIN COLLEEN T 摘要:Antivirulence strategies to combat Pseudomonas aeruginosa , are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.
专利号:US-6967107-B2 优先权日:2004-02-12 标 题 :N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use 发明人:BUECHLER KENNETH F; BANASZCZYK MARIUSZ G; NOAR JOSEPH BARRY 权利人:BIOSITE INC 摘要:The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the present invention can provide advantageous solubility properties in aqueous environments. Such cross-linkers may be used to form conjugates for use in a variety of assay formats.
专利号:US-6566494-B1 优先权日:1996-06-18 标 题 :Support material for solid phase organic synthesis 发明人:JENSEN KNUD J; BARANY GEORGE; SONGSTER MICHAEL F; ALBERICIO FERNANDO; ALSINA JORDI; VAGNER JOSEF 权利人:UNIV MINNESOTA 摘要:A support material for solid phase synthesis is provided having an amine-containing organic group attached to it through a linker. The support material is of the following general formula (Formula I):
专利号:US-7320993-B1 优先权日:1997-12-17 标题 :Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents 发明人:BIEDERMANN ELFI; HASMANN MAX; LOESER ROLAND; RATTEL BENNO; REITER FRIEDEMANN; SCHEIN BARBARA; SEIBEL KLAUS; VOGT KLAUS; WOSIKOWSKI KATJA; SCHEMAINDA ISABEL 权利人:ASTELLAS DEUTSCHLAND GMBH 摘要:The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.
[参考文献]: W M Awad Jr, Et Al. Evidence For Direct Methyl Transfer In Betaine: Homocysteine S-Methyl-Transferase. J Biol Chem. 1983 Nov 10;258(21):12790-2.
合成参考文献
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